Gene description for NUP188
Gene name nucleoporin 188kDa
Gene symbol NUP188
Other names/aliases KIAA0169
hNup188
Species Homo sapiens
 Database cross references - NUP188
ExoCarta ExoCarta_23511
Entrez Gene 23511
HGNC 17859
MIM 615587
UniProt Q5SRE5  
 NUP188 identified in exosomes derived from the following tissue/cell type
Endothelial cells 26027894    
 Gene ontology annotations for NUP188
Biological Process
    protein transport GO:0015031 IEA
    mitotic cell cycle GO:0000278 TAS
    glucose transport GO:0015758 TAS
    viral transcription GO:0019083 TAS
    small molecule metabolic process GO:0044281 TAS
    mitotic nuclear envelope disassembly GO:0007077 TAS
    carbohydrate metabolic process GO:0005975 TAS
    mRNA transport GO:0051028 IEA
    transmembrane transport GO:0055085 TAS
    regulation of cellular response to heat GO:1900034 TAS
    viral life cycle GO:0019058 TAS
    protein sumoylation GO:0016925 TAS
    cellular protein metabolic process GO:0044267 TAS
    regulation of glucose transport GO:0010827 TAS
    hexose transport GO:0008645 TAS
    viral process GO:0016032 TAS
    cellular response to heat GO:0034605 TAS
    gene expression GO:0010467 TAS
    cytokine-mediated signaling pathway GO:0019221 TAS
    post-translational protein modification GO:0043687 TAS
Subcellular Localization
    nuclear pore GO:0005643 IEA
    membrane GO:0016020 IDA
    nuclear envelope GO:0005635 TAS
 Experiment description of studies that identified NUP188 in exosomes
1
Experiment ID 226
ISEV standards
EM
EV Biophysical techniques
GAPDH
EV Cytosolic markers
CD9|FLOT1
EV Membrane markers
LMNA|H2AFX|ATP5A1|TOMM20
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting
Authors Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
2
Experiment ID 226
ISEV standards
EM
EV Biophysical techniques
GAPDH
EV Cytosolic markers
CD9|FLOT1
EV Membrane markers
LMNA|H2AFX|ATP5A1|TOMM20
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting
Authors Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
 Protein-protein interactions for NUP188
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PTP4A3  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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