Gene description for SLAMF1
Gene name signaling lymphocytic activation molecule family member 1
Gene symbol SLAMF1
Other names/aliases CD150
CDw150
SLAM
Species Homo sapiens
 Database cross references - SLAMF1
ExoCarta ExoCarta_6504
Vesiclepedia VP_6504
Entrez Gene 6504
HGNC 10903
MIM 603492
UniProt Q13291  
 SLAMF1 identified in exosomes derived from the following tissue/cell type
B cells 20458337    
B cells 20458337    
B cells 20458337    
Thymus 23844026    
 Gene ontology annotations for SLAMF1
Molecular Function
    protein binding GO:0005515 IPI
    transmembrane signaling receptor activity GO:0004888 TAS
    antigen binding GO:0003823 TAS
Biological Process
    regulation of catalytic activity GO:0050790 IEA
    lymphocyte activation GO:0046649 IEA
    regulation of vesicle fusion GO:0031338 IEA
    signal transduction GO:0007165 TAS
    viral process GO:0016032 IEA
    positive regulation of cell proliferation GO:0008284 TAS
Subcellular Localization
    phagocytic vesicle GO:0045335 IEA
    external side of plasma membrane GO:0009897 IEA
    extracellular exosome GO:0070062 IDA
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified SLAMF1 in exosomes
1
Experiment ID 79
MISEV standards
EV Biophysical techniques
CD81|MHCII
EV Enriched markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis - Sample 1
Authors Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W.
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
2
Experiment ID 80
MISEV standards
EV Biophysical techniques
CD81|MHCII
EV Enriched markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis -Sample 2
Authors Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W.
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
3
Experiment ID 81
MISEV standards
EV Biophysical techniques
CD81|MHCII
EV Enriched markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis - Sample 3
Authors Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W.
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
4
Experiment ID 217
MISEV standards
EM
EV Biophysical techniques
TSG101|CD81|CD9|CD63
EV Enriched markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SLAMF1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SH2D1B  
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
2 FGR 2268
Invivo Homo sapiens
Invitro Homo sapiens
3 PTPN11 5781
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
4 FYN 2534
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
5 SH2D1A 4068
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
6 SLAMF1 6504
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SLAMF1 is involved
No pathways found





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