Gene description for SLAMF1
Gene name signaling lymphocytic activation molecule family member 1
Gene symbol SLAMF1
Other names/aliases CD150
CDw150
SLAM
Species Homo sapiens
 Database cross references - SLAMF1
ExoCarta ExoCarta_6504
Vesiclepedia VP_6504
Entrez Gene 6504
HGNC 10903
MIM 603492
UniProt Q13291  
 SLAMF1 identified in exosomes derived from the following tissue/cell type
B cells 20458337    
B cells 20458337    
B cells 20458337    
Thymus 23844026    
 Gene ontology annotations for SLAMF1
Molecular Function
    virus receptor activity GO:0001618 IDA
    antigen binding GO:0003823 TAS
    transmembrane signaling receptor activity GO:0004888 TAS
    protein binding GO:0005515 IPI
    signaling receptor activity GO:0038023 IBA
    SH2 domain binding GO:0042169 IDA
    identical protein binding GO:0042802 IPI
    cell adhesion mediator activity GO:0098631 IDA
Biological Process
    natural killer cell differentiation GO:0001779 IEA
    natural killer cell proliferation GO:0001787 IEA
    leukocyte chemotaxis involved in inflammatory response GO:0002232 IEA
    adaptive immune response GO:0002250 IEA
    myeloid dendritic cell activation involved in immune response GO:0002277 IDA
    negative regulation of T cell cytokine production GO:0002725 IEA
    phagocytosis GO:0006909 IEA
    immune response GO:0006955 IBA
    cell adhesion GO:0007155 IEA
    positive regulation of cell population proliferation GO:0008284 TAS
    positive regulation of macrophage chemotaxis GO:0010759 IEA
    regulation of vesicle fusion GO:0031338 IEA
    negative regulation of type II interferon production GO:0032689 IEA
    negative regulation of interleukin-12 production GO:0032695 IDA
    negative regulation of interleukin-6 production GO:0032715 IDA
    negative regulation of tumor necrosis factor production GO:0032720 IDA
    positive regulation of type II interferon production GO:0032729 IEA
    positive regulation of activated T cell proliferation GO:0042104 IEA
    innate immune response GO:0045087 IEA
    positive regulation of JNK cascade GO:0046330 IDA
    symbiont entry into host cell GO:0046718 IEA
    positive regulation of ERK1 and ERK2 cascade GO:0070374 IDA
    negative regulation of CD40 signaling pathway GO:2000349 IDA
    positive regulation of dendritic cell chemotaxis GO:2000510 IEA
    positive regulation of T-helper 1 cell cytokine production GO:2000556 IEA
Subcellular Localization
    plasma membrane GO:0005886 IDA
    external side of plasma membrane GO:0009897 IBA
    phagocytic vesicle GO:0045335 IEA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified SLAMF1 in exosomes
1
Experiment ID 79
MISEV standards
Biophysical techniques
CD81|MHCII
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis - Sample 1
Authors "Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W."
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
2
Experiment ID 80
MISEV standards
Biophysical techniques
CD81|MHCII
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis -Sample 2
Authors "Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W."
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
3
Experiment ID 81
MISEV standards
Biophysical techniques
CD81|MHCII
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis - Sample 3
Authors "Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W."
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
4
Experiment ID 217
MISEV standards
EM
Biophysical techniques
TSG101|CD81|CD9|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SLAMF1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 INTS4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 ZNF292  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 MTCH1 23787
Affinity Capture-MS Homo sapiens
4 CNTNAP3  
Affinity Capture-MS Homo sapiens
5 OCLN 100506658
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 C1orf27 54953
Affinity Capture-MS Homo sapiens
7 CTPS2 56474
Affinity Capture-MS Homo sapiens
8 NUP188 23511
Affinity Capture-MS Homo sapiens
9 RTCA 8634
Affinity Capture-MS Homo sapiens
10 ADAM9 8754
Affinity Capture-MS Homo sapiens
11 ATP12A 479
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 INTS2  
Affinity Capture-MS Homo sapiens
13 LGALS1 3956
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 GK2 2712
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 URB2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 ADAMTS2 9509
Affinity Capture-MS Homo sapiens
17 GATB  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 INTS1 26173
Affinity Capture-MS Homo sapiens
19 LTN1 26046
Affinity Capture-MS Homo sapiens
20 MYADM 91663
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 RAB3B 5865
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 ITGA7 3679
Affinity Capture-MS Homo sapiens
23 NKIRAS1  
Affinity Capture-MS Homo sapiens
24 PC 5091
Affinity Capture-MS Homo sapiens
25 MON2 23041
Affinity Capture-MS Homo sapiens
26 D2HGDH 728294
Affinity Capture-MS Homo sapiens
27 SLC39A11  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 NAGA 4668
Affinity Capture-MS Homo sapiens
29 NR2F2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 SEL1L 6400
Affinity Capture-MS Homo sapiens
31 ERAP1 51752
Affinity Capture-MS Homo sapiens
32 INTS12  
Affinity Capture-MS Homo sapiens
33 MAD2L2 10459
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 TAMM41  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 ATP2A3 489
Affinity Capture-MS Homo sapiens
36 TOMM40 10452
Affinity Capture-MS Homo sapiens
37 IL17RA 23765
Affinity Capture-MS Homo sapiens
38 ARFGEF2 10564
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 ATG2B 55102
Affinity Capture-MS Homo sapiens
40 PTPRC 5788
Affinity Capture-Western Homo sapiens
41 ATP1A3 478
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 ST3GAL6 10402
Affinity Capture-MS Homo sapiens
43 DHRS9  
Affinity Capture-MS Homo sapiens
44 EPHA3 2042
Affinity Capture-MS Homo sapiens
45 ANTXR1 84168
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 IGF1R 3480
Affinity Capture-MS Homo sapiens
47 CLSTN1 22883
Affinity Capture-MS Homo sapiens
48 PCSK5 5125
Affinity Capture-MS Homo sapiens
49 CHPT1  
Affinity Capture-MS Homo sapiens
50 FYN 2534
Reconstituted Complex Homo sapiens
51 UQCRC2 7385
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 SH2D1A 4068
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
53 PTCD2  
Affinity Capture-MS Homo sapiens
54 GFPT2 9945
Affinity Capture-MS Homo sapiens
55 INTS7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 BCHE 590
Affinity Capture-MS Homo sapiens
57 BMP7 655
Affinity Capture-MS Homo sapiens
58 FRAS1 80144
Affinity Capture-MS Homo sapiens
59 GK  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 PLXNA2 5362
Affinity Capture-MS Homo sapiens
61 AHCTF1 25909
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 LIFR 3977
Affinity Capture-MS Homo sapiens
63 ANKRD13A 88455
Affinity Capture-MS Homo sapiens
64 ADGRV1 84059
Affinity Capture-MS Homo sapiens
65 CERCAM 51148
Affinity Capture-MS Homo sapiens
66 TNFAIP2 7127
Affinity Capture-MS Homo sapiens
67 HEATR6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
68 CACHD1  
Affinity Capture-MS Homo sapiens
69 PTPN11 5781
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
70 UFSP2 55325
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 HUS1  
Affinity Capture-MS Homo sapiens
72 FASTKD3  
Affinity Capture-MS Homo sapiens
73 HSD17B7 51478
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 RAB5A 5868
Affinity Capture-MS Homo sapiens
75 FAT1 2195
Affinity Capture-MS Homo sapiens
76 SH2D1B  
Protein-peptide Homo sapiens
Two-hybrid Homo sapiens
Protein-peptide Homo sapiens
77 ARFGEF1 10565
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
78 ANKRD13D  
Affinity Capture-MS Homo sapiens
79 NAGLU 4669
Affinity Capture-MS Homo sapiens
80 SGPP1 81537
Affinity Capture-MS Homo sapiens
81 TUBA4A 7277
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
82 SLC27A6  
Affinity Capture-MS Homo sapiens
83 FUT11 170384
Affinity Capture-MS Homo sapiens
84 CHRNA5  
Affinity Capture-MS Homo sapiens
85 TMEM132A 54972
Affinity Capture-MS Homo sapiens
86 LAMA3 3909
Affinity Capture-MS Homo sapiens
87 MROH1 727957
Affinity Capture-MS Homo sapiens
88 XRCC3  
Affinity Capture-MS Homo sapiens
89 INPP5D 3635
Affinity Capture-Western Homo sapiens
90 HEATR1 55127
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
91 CBWD1 55871
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
92 STOML1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
93 Sh2d1b1  
Two-hybrid Mus musculus
Co-crystal Structure Mus musculus
Affinity Capture-Western Mus musculus
94 ATP2B3 492
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
95 RAB18 22931
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
96 FGR 2268
Affinity Capture-Western Homo sapiens
97 GALNS 2588
Affinity Capture-MS Homo sapiens
98 SLC25A6 293
Affinity Capture-MS Homo sapiens
99 TP53 7157
Synthetic Growth Defect Homo sapiens
100 THUMPD3 25917
Affinity Capture-MS Homo sapiens
101 TXNDC15  
Affinity Capture-MS Homo sapiens
102 VPS52 6293
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
103 DSTYK 25778
Affinity Capture-MS Homo sapiens
104 ARF5 381
Affinity Capture-MS Homo sapiens
105 CELSR1 9620
Affinity Capture-MS Homo sapiens
106 TUBB3 10381
Affinity Capture-MS Homo sapiens
107 SLC25A15  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
108 FANCI 55215
Affinity Capture-MS Homo sapiens
109 LARGE 9215
Affinity Capture-MS Homo sapiens
110 OS9 10956
Affinity Capture-MS Homo sapiens
111 RGS13  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
112 NF1 4763
Affinity Capture-MS Homo sapiens
113 TNFRSF10B 8795
Affinity Capture-MS Homo sapiens
114 GALNT18  
Affinity Capture-MS Homo sapiens
115 ATP2B2 491
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
116 LAMB2 3913
Affinity Capture-MS Homo sapiens
117 IPO13 9670
Affinity Capture-MS Homo sapiens
118 SLC1A1 6505
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
119 ANKRD46 157567
Affinity Capture-MS Homo sapiens
120 ARSK  
Affinity Capture-MS Homo sapiens
121 MOXD1 26002
Affinity Capture-MS Homo sapiens
122 CPE 1363
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SLAMF1 is involved
No pathways found





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