Gene description for LIFR
Gene name leukemia inhibitory factor receptor alpha
Gene symbol LIFR
Other names/aliases CD118
Species Homo sapiens
 Database cross references - LIFR
ExoCarta ExoCarta_3977
Entrez Gene 3977
HGNC 6597
MIM 151443
UniProt P42702  
 LIFR identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for LIFR
Molecular Function
    ciliary neurotrophic factor receptor binding GO:0005127 IPI
    leukemia inhibitory factor receptor activity GO:0004923 IDA
    ciliary neurotrophic factor receptor activity GO:0004897 IDA
    growth factor binding GO:0019838 IPI
    oncostatin-M receptor activity GO:0004924 IDA
Biological Process
    cytokine-mediated signaling pathway GO:0019221 IDA
    cell surface receptor signaling pathway GO:0007166 TAS
    ciliary neurotrophic factor-mediated signaling pathway GO:0070120 IDA
    oncostatin-M-mediated signaling pathway GO:0038165 IMP
    positive regulation of cell proliferation GO:0008284 IDA
    leukemia inhibitory factor signaling pathway GO:0048861 IDA
    response to cytokine GO:0034097 IDA
Subcellular Localization
    integral component of plasma membrane GO:0005887 TAS
    receptor complex GO:0043235 IDA
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified LIFR in exosomes
Experiment ID 235
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for LIFR
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PTPN11 5781
Invitro Homo sapiens
Invivo Homo sapiens
2 IL6ST 3572
Affinity Capture-Western Homo sapiens
3 CNTFR 1271
Invitro Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
4 LIF 3976
Reconstituted Complex Homo sapiens
5 OSM 5008
Invivo Homo sapiens
Affinity Capture-Western Homo sapiens
6 PLCG1 5335
Invivo Homo sapiens
7 CTF1  
Invivo Homo sapiens
8 POU2F1  
Invitro Homo sapiens
9 PTPN6 5777
Invivo Homo sapiens
View the network image/svg+xml
 Pathways in which LIFR is involved
No pathways found

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