Gene description for SEC61B
Gene name Sec61 beta subunit
Gene symbol SEC61B
Other names/aliases -
Species Homo sapiens
 Database cross references - SEC61B
ExoCarta ExoCarta_10952
Entrez Gene 10952
HGNC 16993
MIM 609214
UniProt P60468  
 SEC61B identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for SEC61B
Molecular Function
    epidermal growth factor binding GO:0048408 IPI
    protein binding GO:0005515 IPI
    poly(A) RNA binding GO:0044822 IDA
Biological Process
    antigen processing and presentation of peptide antigen via MHC class I GO:0002474 TAS
    endoplasmic reticulum unfolded protein response GO:0030968 TAS
    translation GO:0006412 TAS
    cellular protein metabolic process GO:0044267 TAS
    protein import into nucleus, translocation GO:0000060 IMP
    gene expression GO:0010467 TAS
    retrograde protein transport, ER to cytosol GO:0030970 IMP
    IRE1-mediated unfolded protein response GO:0036498 TAS
    antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 TAS
    ER-associated ubiquitin-dependent protein catabolic process GO:0030433 IDA
    antigen processing and presentation of exogenous peptide antigen via MHC class I GO:0042590 TAS
    SRP-dependent cotranslational protein targeting to membrane GO:0006614 TAS
Subcellular Localization
    membrane GO:0016020 IDA
    cytosol GO:0005829 TAS
    Sec61 translocon complex GO:0005784 IEA
    integral component of membrane GO:0016021 NAS
    endoplasmic reticulum Sec complex GO:0031205 ISS
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum membrane GO:0005789 TAS
 Experiment description of studies that identified SEC61B in exosomes
Experiment ID 224
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for SEC61B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SPBC25  
Invivo Homo sapiens
2 SEC63  
Invitro Homo sapiens
3 APOB 338
Invivo Homo sapiens
4 ARL6 84100
Affinity Capture-Western Homo sapiens
View the network image/svg+xml

Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here