Gene description for ARL6
Gene name ADP-ribosylation factor-like 6
Gene symbol ARL6
Other names/aliases BBS3
Species Homo sapiens
 Database cross references - ARL6
ExoCarta ExoCarta_84100
Entrez Gene 84100
HGNC 13210
MIM 608845
UniProt Q9H0F7  
 ARL6 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for ARL6
Molecular Function
    protein binding GO:0005515 IPI
    metal ion binding GO:0046872 IEA
    GTP binding GO:0005525 IEA
    phospholipid binding GO:0005543 ISS
Biological Process
    brain development GO:0007420 IEA
    organelle organization GO:0006996 TAS
    regulation of smoothened signaling pathway GO:0008589 IEA
    protein polymerization GO:0051258 ISS
    protein targeting to membrane GO:0006612 ISS
    Wnt signaling pathway GO:0016055 IMP
    retina layer formation GO:0010842 IEA
    cilium assembly GO:0042384 ISS
    determination of left/right symmetry GO:0007368 ISS
    small GTPase mediated signal transduction GO:0007264 IEA
    fat cell differentiation GO:0045444 IEA
    visual perception GO:0007601 IEA
    protein localization to cilium GO:0061512 IMP
    melanosome transport GO:0032402 ISS
    intermembrane transport GO:0046909 IEA
Subcellular Localization
    axonemal microtubule GO:0005879 ISS
    cytosol GO:0005829 IEA
    BBSome GO:0034464 ISS
    primary cilium GO:0072372 TAS
    axoneme GO:0005930 ISS
    cytoplasm GO:0005737 ISS
    cilium GO:0005929 IDA
    extracellular exosome GO:0070062 IDA
    membrane coat GO:0030117 ISS
    plasma membrane GO:0005886 TAS
    membrane GO:0016020 ISS
    ciliary membrane GO:0060170 IEA
 Experiment description of studies that identified ARL6 in exosomes
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for ARL6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ARL6IP5 10550
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
2 ATL2 64225
Two-hybrid Homo sapiens
3 ARL6IP6  
Two-hybrid Homo sapiens
4 ARL6IP4  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
5 SEC61B 10952
Affinity Capture-Western Homo sapiens
6 ARL6IP1 23204
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which ARL6 is involved
BBSome-mediated cargo-targeting to cilium TAS Reactome

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