Gene description for TOR1AIP2
Gene name torsin A interacting protein 2
Gene symbol TOR1AIP2
Other names/aliases IFRG15
LULL1
NET9
Species Homo sapiens
 Database cross references - TOR1AIP2
ExoCarta ExoCarta_163590
Vesiclepedia VP_163590
Entrez Gene 163590
HGNC 24055
MIM 614513
UniProt Q9H496   Q8NFQ8  
 TOR1AIP2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Endothelial cells 26027894    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for TOR1AIP2
Molecular Function
    ATPase activator activity GO:0001671 IDA
    protein binding GO:0005515 IPI
    ATPase binding GO:0051117 IPI
Biological Process
    endoplasmic reticulum organization GO:0007029 IBA
    endoplasmic reticulum organization GO:0007029 IMP
    positive regulation of ATP-dependent activity GO:0032781 IDA
    membrane organization GO:0061024 IBA
    protein localization to nuclear envelope GO:0090435 IDA
Subcellular Localization
    endoplasmic reticulum GO:0005783 IBA
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum membrane GO:0005789 IEA
    membrane GO:0016020 IBA
    nuclear membrane GO:0031965 IEA
 Experiment description of studies that identified TOR1AIP2 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 226
MISEV standards
EM
Biophysical techniques
GAPDH|CD9|FLOT1
Enriched markers
LMNA|H2AFX|ATP5A1|TOMM20
Negative markers
Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description "Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting"
Authors "Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar"
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
6
Experiment ID 834
MISEV standards
EM
Biophysical techniques
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
7
Experiment ID 835
MISEV standards
EM
Biophysical techniques
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for TOR1AIP2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HSD17B11 51170
Proximity Label-MS Homo sapiens
2 KLK15  
Affinity Capture-MS Homo sapiens
3 TOR1A 1861
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
4 RBPMS 11030
Two-hybrid Homo sapiens
5 MARCKS 4082
Proximity Label-MS Homo sapiens
6 LAMP3  
Proximity Label-MS Homo sapiens
7 SH3BP4 23677
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 RAB15 376267
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 GCNT1  
Affinity Capture-MS Homo sapiens
10 COPS6 10980
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 MTFP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 TUBB8 347688
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 GJD3  
Proximity Label-MS Homo sapiens
14 UBC 7316
Reconstituted Complex Homo sapiens
15 DNAJC25 548645
Proximity Label-MS Homo sapiens
16 TRIM55  
Two-hybrid Homo sapiens
17 PTPN1 5770
Proximity Label-MS Homo sapiens
18 STX4 6810
Proximity Label-MS Homo sapiens
19 SLC16A10 117247
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 NR2F2  
Affinity Capture-MS Homo sapiens
21 COPS5 10987
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 UBD  
Affinity Capture-Western Homo sapiens
23 GNL3L 54552
Affinity Capture-MS Homo sapiens
24 TM2D3  
Affinity Capture-MS Homo sapiens
25 B3GAT1  
Proximity Label-MS Homo sapiens
26 DDA1  
Affinity Capture-MS Homo sapiens
27 MCU 90550
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 B3GNT2 10678
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 SPRTN  
Affinity Capture-MS Homo sapiens
30 USP3 9960
Affinity Capture-MS Homo sapiens
31 FAM174A 345757
Affinity Capture-MS Homo sapiens
32 RAB3B 5865
Proximity Label-MS Homo sapiens
33 SSR1 6745
Proximity Label-MS Homo sapiens
34 SLC10A7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 SLC25A46 91137
Proximity Label-MS Homo sapiens
36 XRCC3  
Affinity Capture-MS Homo sapiens
37 FPGS 2356
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 TMEM106A  
Affinity Capture-MS Homo sapiens
39 FAM20C 56975
Affinity Capture-MS Homo sapiens
40 NDUFA1 4694
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 METTL7A 25840
Proximity Label-MS Homo sapiens
42 LMAN1 3998
Proximity Label-MS Homo sapiens
43 NUP155 9631
Proximity Label-MS Homo sapiens
44 KIAA1715 80856
Proximity Label-MS Homo sapiens
45 PXMP2  
Proximity Label-MS Homo sapiens
46 LRRC59 55379
Proximity Label-MS Homo sapiens
47 PANX1 24145
Proximity Label-MS Homo sapiens
48 POMGNT1 55624
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 CANT1 124583
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 C19orf52  
Affinity Capture-MS Homo sapiens
51 TOR1B 27348
Affinity Capture-Western Homo sapiens
52 EMD 2010
Proximity Label-MS Homo sapiens
53 CUL4B 8450
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 PARK2  
Affinity Capture-MS Homo sapiens
55 Ddb1 13194
Affinity Capture-MS Mus musculus
56 XPO1 7514
Affinity Capture-MS Homo sapiens
57 SFXN3 81855
Affinity Capture-MS Homo sapiens
58 TUBGCP4 27229
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 RAB4A 5867
Proximity Label-MS Homo sapiens
60 ARL6 84100
Affinity Capture-MS Homo sapiens
61 SYNJ2BP 55333
Co-fractionation Homo sapiens
62 OGT 8473
Reconstituted Complex Homo sapiens
63 INTS7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 RPN1 6184
Proximity Label-MS Homo sapiens
65 COPS3 8533
Affinity Capture-MS Homo sapiens
66 SLC25A16  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 ELOVL5 60481
Proximity Label-MS Homo sapiens
68 SEC61B 10952
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 RAD21 5885
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 TRIM63  
Two-hybrid Homo sapiens
71 RMDN3 55177
Proximity Label-MS Homo sapiens
72 REEP5 7905
Proximity Label-MS Homo sapiens
73 SEC63 11231
Proximity Label-MS Homo sapiens
74 PRG2  
Affinity Capture-MS Homo sapiens
75 CYB5B 80777
Co-fractionation Homo sapiens
76 APLNR  
Affinity Capture-MS Homo sapiens
77 HADHB 3032
Co-fractionation Homo sapiens
78 RPN2 6185
Proximity Label-MS Homo sapiens
79 CANX 821
Affinity Capture-MS Homo sapiens
80 RPL23 9349
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
81 RPS2 6187
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
82 RAB5A 5868
Proximity Label-MS Homo sapiens
83 LMNB1 4001
Proximity Label-MS Homo sapiens
84 SLC20A2 6575
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
85 TVP23C  
Affinity Capture-MS Homo sapiens
86 TMEM223  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
87 BCAP31 10134
Proximity Label-MS Homo sapiens
88 HSD3B7 80270
Proximity Label-MS Homo sapiens
89 NR3C1 2908
Proximity Label-MS Homo sapiens
90 STIM1 6786
Proximity Label-MS Homo sapiens
91 ARF6 382
Proximity Label-MS Homo sapiens
92 FBXO6 26270
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
93 SAMD1  
Affinity Capture-MS Homo sapiens
94 C17orf80 55028
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
95 MTCH1 23787
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
96 SLC38A10 124565
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
97 EXT1 2131
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
98 C4orf29 80167
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
99 GALNT11 63917
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
100 ATP2A1 487
Proximity Label-MS Homo sapiens
101 RAB9A 9367
Proximity Label-MS Homo sapiens
102 RREB1 6239
Affinity Capture-MS Homo sapiens
103 DDB1 1642
Affinity Capture-MS Homo sapiens
104 CYP2C9  
Proximity Label-MS Homo sapiens
105 CCND1 595
Affinity Capture-MS Homo sapiens
106 LMNA 4000
Proximity Label-MS Homo sapiens
107 SLC25A30 253512
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
108 MGAT2 4247
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
109 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
110 ABCB6 10058
Co-fractionation Homo sapiens
111 TP53 7157
Affinity Capture-MS Homo sapiens
112 PDIA4 9601
Proximity Label-MS Homo sapiens
113 TPTE  
Proximity Label-MS Homo sapiens
114 CUL5 8065
Affinity Capture-MS Homo sapiens
115 POP4 10775
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
116 TUBB3 10381
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
117 RBM15 64783
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
118 ERGIC1 57222
Proximity Label-MS Homo sapiens
119 NSUN3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
120 TUBB1 81027
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
121 ACSL4 2182
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
122 SFTPC  
Affinity Capture-MS Homo sapiens
123 ERGIC2 51290
Proximity Label-MS Homo sapiens
124 SEC62 7095
Proximity Label-MS Homo sapiens
125 SLC25A14  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
126 ITPA 3704
Affinity Capture-MS Homo sapiens
127 RAB7A 7879
Proximity Label-MS Homo sapiens
128 MYO1D 4642
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
129 ENTPD6  
Affinity Capture-MS Homo sapiens
130 PXYLP1  
Affinity Capture-MS Homo sapiens
131 BRD1 23774
Affinity Capture-MS Homo sapiens
132 EPHA2 1969
Proximity Label-MS Homo sapiens
133 SERBP1 26135
Affinity Capture-MS Homo sapiens
134 DNAJC1 64215
Proximity Label-MS Homo sapiens
135 RAB5C 5878
Proximity Label-MS Homo sapiens
136 C9orf72  
Affinity Capture-MS Homo sapiens
137 ABHD17B 51104
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
138 CKAP4 10970
Proximity Label-MS Homo sapiens
139 COPS4 51138
Affinity Capture-MS Homo sapiens
140 TRAV20  
Affinity Capture-MS Homo sapiens
141 RPP38 10557
Affinity Capture-MS Homo sapiens
142 CALR3  
Proximity Label-MS Homo sapiens
143 CUL4A 8451
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
144 ZNF146  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
145 DERL1 79139
Proximity Label-MS Homo sapiens
View the network image/svg+xml
 Pathways in which TOR1AIP2 is involved
No pathways found





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