Gene description for USP3
Gene name ubiquitin specific peptidase 3
Gene symbol USP3
Other names/aliases SIH003
Species Homo sapiens
 Database cross references - USP3
ExoCarta ExoCarta_9960
Entrez Gene 9960
HGNC 12626
MIM 604728
UniProt Q9Y6I4  
 USP3 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for USP3
Molecular Function
    ubiquitin-specific protease activity GO:0004843 TAS
    histone binding GO:0042393 IPI
    zinc ion binding GO:0008270 IEA
    cysteine-type endopeptidase activity GO:0004197 IBA
    core promoter sequence-specific DNA binding GO:0001046 IEA
    chromatin binding GO:0003682 IEA
Biological Process
    mitotic cell cycle GO:0000278 IMP
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IBA
    DNA repair GO:0006281 IMP
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IEA
    regulation of transcription, DNA-templated GO:0006355 IBA
    regulation of protein stability GO:0031647 IDA
    histone deubiquitination GO:0016578 IDA
    regulation of proteasomal protein catabolic process GO:0061136 IBA
Subcellular Localization
    nuclear chromatin GO:0000790 IDA
    nucleus GO:0005634 IBA
 Experiment description of studies that identified USP3 in exosomes
Experiment ID 237
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for USP3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which USP3 is involved
No pathways found

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