Gene description for TXNDC17
Gene name thioredoxin domain containing 17
Gene symbol TXNDC17
Other names/aliases TRP14
TXNL5
Species Homo sapiens
 Database cross references - TXNDC17
ExoCarta ExoCarta_84817
Entrez Gene 84817
HGNC 28218
UniProt Q9BRA2  
 TXNDC17 identified in exosomes derived from the following tissue/cell type
Squamous carcinoma cells 20124223    
Urine 19056867    
 Gene ontology annotations for TXNDC17
Molecular Function
    peroxidase activity GO:0004601 IDA
    electron carrier activity GO:0009055 IDA
    protein binding GO:0005515 IPI
    protein-disulfide reductase activity GO:0047134 IDA
Biological Process
    oxidation-reduction process GO:0055114 IDA
    tumor necrosis factor-mediated signaling pathway GO:0033209 IMP
Subcellular Localization
    cytosol GO:0005829 IDA
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified TXNDC17 in exosomes
1
Experiment ID 191
ISEV standards
EV Biophysical techniques
Alix
EV Cytosolic markers
CD81|CD9
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK.
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for TXNDC17
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DYNLL1 8655
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
2 INS 3630
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
3 CFL1 1072
Affinity Capture-MS Homo sapiens
4 AVP  
Biochemical Activity Homo sapiens
5 OXT  
Biochemical Activity Homo sapiens
View the network image/svg+xml
 Pathways in which TXNDC17 is involved
No pathways found





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