Gene description for INS
Gene name	insulin
Gene symbol	INS
Other names/aliases	IDDM IDDM1 IDDM2 ILPR IRDN MODY10
Species	Homo sapiens
Database cross references - INS
ExoCarta	ExoCarta_3630
Entrez Gene	3630
HGNC	6081
MIM	176730
UniProt	P01308
INS identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells	26054723

Gene ontology annotations for INS

Molecular Function     protein binding GO:0005515 IPI     insulin-like growth factor receptor binding GO:0005159 IPI     hormone activity GO:0005179 NAS     identical protein binding GO:0042802 IPI     protease binding GO:0002020 IPI     insulin receptor binding GO:0005158 IPI Biological Process     negative regulation of NAD(P)H oxidase activity GO:0033861 IDA     positive regulation of glycogen biosynthetic process GO:0045725 IDA     acute-phase response GO:0006953 IDA     regulation of transmembrane transporter activity GO:0022898 IDA     small molecule metabolic process GO:0044281 TAS     wound healing GO:0042060 IDA     regulation of protein localization GO:0032880 IDA     positive regulation of MAPK cascade GO:0043410 IDA     insulin receptor signaling pathway GO:0008286 TAS     negative regulation of feeding behavior GO:2000252 IDA     alpha-beta T cell activation GO:0046631 IDA     positive regulation of protein localization to nucleus GO:1900182 IDA     positive regulation of vasodilation GO:0045909 NAS     negative regulation of glycogen catabolic process GO:0045818 IMP     positive regulation of protein autophosphorylation GO:0031954 ISS     positive regulation of brown fat cell differentiation GO:0090336 TAS     glucose homeostasis GO:0042593 IMP     cell-cell signaling GO:0007267 IC     negative regulation of respiratory burst involved in inflammatory response GO:0060266 IDA     positive regulation of insulin receptor signaling pathway GO:0046628 IDA     negative regulation of protein secretion GO:0050709 IDA     positive regulation of mitotic nuclear division GO:0045840 IDA     negative regulation of lipid catabolic process GO:0050995 NAS     activation of protein kinase B activity GO:0032148 IDA     positive regulation of peptide hormone secretion GO:0090277 TAS     fatty acid homeostasis GO:0055089 IMP     negative regulation of gluconeogenesis GO:0045721 NAS     positive regulation of cell growth GO:0030307 NAS     positive regulation of cell proliferation GO:0008284 IDA     positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 IDA     negative regulation of proteolysis GO:0045861 IMP     negative regulation of protein catabolic process GO:0042177 IDA     positive regulation of lipid biosynthetic process GO:0046889 NAS     positive regulation of glucose import GO:0046326 IDA     positive regulation of nitric oxide biosynthetic process GO:0045429 NAS     negative regulation of vasodilation GO:0045908 NAS     positive regulation of nitric-oxide synthase activity GO:0051000 NAS     energy reserve metabolic process GO:0006112 TAS     positive regulation of cell differentiation GO:0045597 NAS     MAPK cascade GO:0000165 IDA     positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IDA     negative regulation of acute inflammatory response GO:0002674 IDA     endocrine pancreas development GO:0031018 TAS     positive regulation of DNA replication GO:0045740 IDA     regulation of insulin secretion GO:0050796 TAS     negative regulation of protein oligomerization GO:0032460 IDA     negative regulation of fatty acid metabolic process GO:0045922 IMP     regulation of protein secretion GO:0050708 IDA     positive regulation of cellular protein metabolic process GO:0032270 IMP     positive regulation of cell migration GO:0030335 ISS     regulation of transcription, DNA-templated GO:0006355 NAS     negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GO:1902176 NAS     glucose metabolic process GO:0006006 IEA     positive regulation of NF-kappaB transcription factor activity GO:0051092 IDA     cellular protein metabolic process GO:0044267 TAS     G-protein coupled receptor signaling pathway GO:0007186 IDA     positive regulation of protein kinase B signaling GO:0051897 IDA     positive regulation of cytokine secretion GO:0050715 IDA     positive regulation of respiratory burst GO:0060267 IDA     positive regulation of glycolytic process GO:0045821 IMP     glucose transport GO:0015758 IDA     regulation of cellular amino acid metabolic process GO:0006521 IMP Subcellular Localization     Golgi lumen GO:0005796 TAS     extracellular region GO:0005576 TAS     endosome lumen GO:0031904 TAS     extracellular space GO:0005615 IDA     endoplasmic reticulum lumen GO:0005788 TAS     secretory granule lumen GO:0034774 TAS