Gene description for INS
Gene name	insulin
Gene symbol	INS
Other names/aliases	IDDM IDDM1 IDDM2 ILPR IRDN MODY10
Species	Homo sapiens
Database cross references - INS
ExoCarta	ExoCarta_3630
Vesiclepedia	VP_3630
Entrez Gene	3630
HGNC	6081
MIM	176730
UniProt	P01308
INS identified in sEVs derived from the following tissue/cell type
Hepatocellular carcinoma cells	26054723

Gene ontology annotations for INS

Molecular Function     protease binding GO:0002020 IPI     insulin receptor binding GO:0005158 IDA     insulin receptor binding GO:0005158 IPI     insulin-like growth factor receptor binding GO:0005159 IPI     hormone activity GO:0005179 IC     hormone activity GO:0005179 IMP     hormone activity GO:0005179 NAS     protein binding GO:0005515 IPI     identical protein binding GO:0042802 IPI Biological Process     positive regulation of cytokine production GO:0001819 IDA     negative regulation of acute inflammatory response GO:0002674 IDA     glucose metabolic process GO:0006006 IEA     regulation of DNA-templated transcription GO:0006355 NAS     regulation of amino acid metabolic process GO:0006521 IMP     acute-phase response GO:0006953 IDA     G protein-coupled receptor signaling pathway GO:0007186 IDA     cell-cell signaling GO:0007267 IC     positive regulation of cell population proliferation GO:0008284 IDA     insulin receptor signaling pathway GO:0008286 IDA     insulin receptor signaling pathway GO:0008286 IMP     positive regulation of gene expression GO:0010628 IGI     negative regulation of gene expression GO:0010629 IDA     positive regulation of nitric oxide mediated signal transduction GO:0010750 IDA     positive regulation of nitric oxide mediated signal transduction GO:0010750 IMP     positive regulation of neuron projection development GO:0010976 IC     regulation of transmembrane transporter activity GO:0022898 IDA     positive regulation of cell growth GO:0030307 NAS     positive regulation of cell migration GO:0030335 ISS     positive regulation of protein autophosphorylation GO:0031954 ISS     activation of protein kinase B activity GO:0032148 IDA     regulation of protein localization GO:0032880 IDA     negative regulation of NAD(P)H oxidase activity GO:0033861 IDA     nitric oxide-cGMP-mediated signaling GO:0038060 IDA     wound healing GO:0042060 IDA     negative regulation of protein catabolic process GO:0042177 IDA     vasodilation GO:0042311 IDA     vasodilation GO:0042311 NAS     glucose homeostasis GO:0042593 IBA     glucose homeostasis GO:0042593 IMP     positive regulation of MAPK cascade GO:0043410 IDA     positive regulation of cell differentiation GO:0045597 NAS     negative regulation of gluconeogenesis GO:0045721 NAS     positive regulation of glycogen biosynthetic process GO:0045725 IDA     negative regulation of glycogen catabolic process GO:0045818 IMP     positive regulation of glycolytic process GO:0045821 IDA     positive regulation of glycolytic process GO:0045821 IMP     positive regulation of mitotic nuclear division GO:0045840 IDA     negative regulation of proteolysis GO:0045861 IMP     negative regulation of fatty acid metabolic process GO:0045922 IMP     positive regulation of D-glucose import GO:0046326 IDA     positive regulation of insulin receptor signaling pathway GO:0046628 IDA     alpha-beta T cell activation GO:0046631 IDA     positive regulation of lipid biosynthetic process GO:0046889 NAS     regulation of synaptic plasticity GO:0048167 TAS     regulation of protein secretion GO:0050708 IDA     negative regulation of protein secretion GO:0050709 IDA     positive regulation of protein secretion GO:0050714 IBA     cognition GO:0050890 TAS     negative regulation of lipid catabolic process GO:0050995 IMP     negative regulation of lipid catabolic process GO:0050995 NAS     positive regulation of nitric-oxide synthase activity GO:0051000 NAS     positive regulation of NF-kappaB transcription factor activity GO:0051092 IDA     positive regulation of protein metabolic process GO:0051247 IMP     positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 IDA     fatty acid homeostasis GO:0055089 IMP     negative regulation of respiratory burst involved in inflammatory response GO:0060266 IDA     positive regulation of respiratory burst GO:0060267 IDA     positive regulation of peptide hormone secretion GO:0090277 TAS     positive regulation of brown fat cell differentiation GO:0090336 TAS     positive regulation of protein localization to nucleus GO:1900182 IDA     positive regulation of long-term synaptic potentiation GO:1900273 TAS     negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GO:1902176 NAS     positive regulation of dendritic spine maintenance GO:1902952 IGI     regulation of protein localization to plasma membrane GO:1903076 IGI     negative regulation of reactive oxygen species biosynthetic process GO:1903427 IGI     neuron projection maintenance GO:1990535 IGI     negative regulation of feeding behavior GO:2000252 IDA Subcellular Localization     Golgi membrane GO:0000139 TAS     extracellular region GO:0005576 IC     extracellular region GO:0005576 TAS     extracellular space GO:0005615 IBA     extracellular space GO:0005615 IDA     endoplasmic reticulum lumen GO:0005788 TAS     Golgi lumen GO:0005796 TAS     transport vesicle GO:0030133 TAS     endosome lumen GO:0031904 TAS     endoplasmic reticulum-Golgi intermediate compartment membrane GO:0033116 TAS     secretory granule lumen GO:0034774 TAS