Gene description for LINGO1
Gene name leucine rich repeat and Ig domain containing 1
Gene symbol LINGO1
Other names/aliases LERN1
LRRN6A
UNQ201
Species Homo sapiens
 Database cross references - LINGO1
ExoCarta ExoCarta_84894
Entrez Gene 84894
HGNC 21205
MIM 609791
UniProt Q96FE5  
 LINGO1 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for LINGO1
Molecular Function
    protein binding GO:0005515 IPI
    epidermal growth factor receptor binding GO:0005154 IEA
Biological Process
    protein kinase B signaling GO:0043491 IEA
    central nervous system neuron development GO:0021954 IEA
    neuron projection development GO:0031175 IEA
    negative regulation of axonogenesis GO:0050771 TAS
    negative regulation of oligodendrocyte differentiation GO:0048715 IEA
    regulation of axonogenesis GO:0050770 TAS
    neurotrophin TRK receptor signaling pathway GO:0048011 TAS
Subcellular Localization
    integral component of membrane GO:0016021 IEA
    plasma membrane GO:0005886 TAS
    intracellular GO:0005622 IEA
 Experiment description of studies that identified LINGO1 in exosomes
1
Experiment ID 224
ISEV standards
EM|AFM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81
EV Membrane markers
GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for LINGO1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FBXW7  
Two-hybrid Homo sapiens
2 KRTAP4-12  
Two-hybrid Homo sapiens
3 EFEMP2 30008
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which LINGO1 is involved
PathwayEvidenceSource
Axonal growth inhibition (RHOA activation) TAS Reactome





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