Gene description for NTRK3
Gene name neurotrophic tyrosine kinase, receptor, type 3
Gene symbol NTRK3
Other names/aliases GP145-TrkC
TRKC
gp145(trkC)
Species Homo sapiens
 Database cross references - NTRK3
ExoCarta ExoCarta_4916
Vesiclepedia VP_4916
Entrez Gene 4916
HGNC 8033
MIM 191316
UniProt Q16288  
 NTRK3 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for NTRK3
Molecular Function
    protein binding GO:0005515 IPI
    p53 binding GO:0002039 IPI
    neurotrophin receptor activity GO:0005030 IDA
    neurotrophin binding GO:0043121 TAS
    transmembrane receptor protein tyrosine kinase activity GO:0004714 IEA
    ATP binding GO:0005524 IEA
    ephrin receptor binding GO:0046875 IEA
Biological Process
    positive regulation of actin cytoskeleton reorganization GO:2000251 IDA
    negative regulation of protein phosphorylation GO:0001933 IDA
    response to corticosterone GO:0051412 IEA
    protein autophosphorylation GO:0046777 IEA
    neuron fate specification GO:0048665 IEA
    positive regulation of peptidyl-serine phosphorylation GO:0033138 IDA
    cellular response to retinoic acid GO:0071300 IEA
    positive regulation of cell migration GO:0030335 IDA
    modulation by virus of host transcription GO:0019056 IEA
    positive regulation of axon extension involved in regeneration GO:0048691 IEA
    cochlea development GO:0090102 IEA
    response to ethanol GO:0045471 IEA
    circadian rhythm GO:0007623 IEA
    negative regulation of astrocyte differentiation GO:0048712 IEA
    activation of MAPK activity GO:0000187 IDA
    activation of GTPase activity GO:0090630 IDA
    negative regulation of cell death GO:0060548 IEA
    positive regulation of gene expression GO:0010628 IDA
    positive regulation of positive chemotaxis GO:0050927 IDA
    lens fiber cell differentiation GO:0070306 IEA
    peptidyl-tyrosine phosphorylation GO:0018108 IEA
    positive regulation of cell proliferation GO:0008284 IDA
    neuron migration GO:0001764 IEA
    activation of protein kinase B activity GO:0032148 IDA
    mechanoreceptor differentiation GO:0042490 IEA
    transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 IDA
    neurotrophin signaling pathway GO:0038179 IEA
    response to axon injury GO:0048678 IEA
Subcellular Localization
    integral component of plasma membrane GO:0005887 IEA
    cytoplasm GO:0005737 IEA
    receptor complex GO:0043235 IDA
 Experiment description of studies that identified NTRK3 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for NTRK3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NTF3  
Reconstituted Complex Homo sapiens
2 NGFRAP1  
Affinity Capture-MS Homo sapiens
3 SQSTM1 8878
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
4 PLCG1 5335
Reconstituted Complex Homo sapiens
5 NGFR 4804
Invivo Homo sapiens
6 FRS2 10818
Reconstituted Complex Homo sapiens
7 PTPN1 5770
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
8 SHC1 6464
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which NTRK3 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here