Gene description for CXCR4
Gene name	chemokine (C-X-C motif) receptor 4
Gene symbol	CXCR4
Other names/aliases	CD184 D2S201E FB22 HM89 HSY3RR LAP-3 LAP3 LCR1 LESTR NPY3R NPYR NPYRL NPYY3R WHIM WHIMS
Species	Homo sapiens
Database cross references - CXCR4
ExoCarta	ExoCarta_7852
Vesiclepedia	VP_7852
Entrez Gene	7852
HGNC	2561
MIM	162643
UniProt	P61073
CXCR4 identified in sEVs derived from the following tissue/cell type
B cells	20458337
B cells	20458337
B cells	20458337
Platelets	25332113
Platelets	25332113
Platelets	25332113
T cells	11907077

Gene ontology annotations for CXCR4

Molecular Function     virus receptor activity GO:0001618 IEA     actin binding GO:0003779 IDA     G protein-coupled receptor activity GO:0004930 TAS     protein binding GO:0005515 IPI     coreceptor activity GO:0015026 TAS     C-C chemokine receptor activity GO:0016493 IBA     C-X-C chemokine receptor activity GO:0016494 NAS     C-C chemokine binding GO:0019957 IBA     C-C chemokine binding GO:0019957 IPI     ubiquitin protein ligase binding GO:0031625 IPI     myosin light chain binding GO:0032027 IDA     small molecule binding GO:0036094 IEA     C-X-C motif chemokine 12 receptor activity GO:0038147 IDA     ubiquitin binding GO:0043130 IDA Biological Process     response to hypoxia GO:0001666 IEP     neuron migration GO:0001764 IEA     epithelial cell development GO:0002064 IEA     dendritic cell chemotaxis GO:0002407 TAS     apoptotic process GO:0006915 TAS     inflammatory response GO:0006954 TAS     immune response GO:0006955 IBA     G protein-coupled receptor signaling pathway GO:0007186 IDA     positive regulation of cytosolic calcium ion concentration GO:0007204 IBA     brain development GO:0007420 IBA     neuron recognition GO:0008038 IEA     response to virus GO:0009615 TAS     response to activity GO:0014823 IEA     calcium-mediated signaling GO:0019722 IBA     calcium-mediated signaling GO:0019722 IMP     neurogenesis GO:0022008 IBA     telencephalon cell migration GO:0022029 IEA     regulation of cell adhesion GO:0030155 IDA     positive regulation of cell migration GO:0030335 IMP     positive regulation of vascular wound healing GO:0035470 IEA     CXCL12-activated CXCR4 signaling pathway GO:0038160 IDA     CXCL12-activated CXCR4 signaling pathway GO:0038160 IGI     CXCL12-activated CXCR4 signaling pathway GO:0038160 IMP     regulation of programmed cell death GO:0043067 IEA     myelin maintenance GO:0043217 ISS     endothelial cell differentiation GO:0045446 IEA     symbiont entry into host cell GO:0046718 IEA     positive regulation of oligodendrocyte differentiation GO:0048714 ISS     regulation of viral process GO:0050792 IEA     regulation of chemotaxis GO:0050920 IMP     positive regulation of chemotaxis GO:0050921 IEA     detection of temperature stimulus involved in sensory perception of pain GO:0050965 IEA     detection of mechanical stimulus involved in sensory perception of pain GO:0050966 IEA     regulation of calcium ion transport GO:0051924 IEA     cardiac muscle contraction GO:0060048 IEA     cell chemotaxis GO:0060326 IBA     endothelial tube morphogenesis GO:0061154 IEA     cellular response to cytokine stimulus GO:0071345 IDA     cellular response to xenobiotic stimulus GO:0071466 IEA     positive regulation of cold-induced thermogenesis GO:0120162 ISS     response to tacrolimus GO:1901327 IEA     positive regulation of dendrite extension GO:1903861 IEA     positive regulation of vasculature development GO:1904018 IMP     positive regulation of mesenchymal stem cell migration GO:1905322 IEA     response to ultrasound GO:1990478 IEA     positive regulation of macrophage migration inhibitory factor signaling pathway GO:2000448 IMP Subcellular Localization     cytoplasm GO:0005737 TAS     lysosome GO:0005764 IDA     lysosome GO:0005764 IDA     early endosome GO:0005769 IDA     early endosome GO:0005769 IDA     late endosome GO:0005770 IDA     plasma membrane GO:0005886 IDA     plasma membrane GO:0005886 TAS     external side of plasma membrane GO:0009897 IBA     cell surface GO:0009986 IDA     cell leading edge GO:0031252 IDA     cytoplasmic vesicle GO:0031410 IDA     protein-containing complex GO:0032991 IDA     protein-containing complex GO:0032991 IMP     extracellular exosome GO:0070062 HDA     anchoring junction GO:0070161 IEA