Gene description for EXOG
Gene name endo/exonuclease (5'-3'), endonuclease G-like
Gene symbol EXOG
Other names/aliases ENDOGL1
ENDOGL2
ENGL
ENGL-a
ENGL-b
ENGLA
ENGLB
Species Homo sapiens
 Database cross references - EXOG
ExoCarta ExoCarta_9941
Vesiclepedia VP_9941
Entrez Gene 9941
HGNC 3347
MIM 604051
UniProt Q9Y2C4  
 EXOG identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for EXOG
Molecular Function
    single-stranded DNA endodeoxyribonuclease activity GO:0000014 IBA
    nucleic acid binding GO:0003676 IEA
    endonuclease activity GO:0004519 IDA
    endonuclease activity GO:0004519 NAS
    RNA endonuclease activity GO:0004521 IBA
    protein binding GO:0005515 IPI
    5'-3' exonuclease activity GO:0008409 IBA
    5'-3' exonuclease activity GO:0008409 IDA
    metal ion binding GO:0046872 IEA
Biological Process
    apoptotic DNA fragmentation GO:0006309 IBA
Subcellular Localization
    nucleus GO:0005634 IBA
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IDA
    mitochondrial inner membrane GO:0005743 IBA
    mitochondrial inner membrane GO:0005743 IDA
    protein-containing complex GO:0032991 IDA
 Experiment description of studies that identified EXOG in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for EXOG
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CXCR4 7852
Affinity Capture-MS Homo sapiens
2 AIFM1 9131
Proximity Label-MS Homo sapiens
3 LAMTOR1 55004
Affinity Capture-MS Homo sapiens
4 TMA7 51372
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
5 FOXP1 27086
Protein-RNA Homo sapiens
6 PEX19 5824
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 APOO 79135
Proximity Label-MS Homo sapiens
8 BZW2 28969
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 CDH5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 VSIG1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 GNG8  
Affinity Capture-MS Homo sapiens
12 RANBP6 26953
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 PNMAL1  
Affinity Capture-MS Homo sapiens
14 SAAL1 113174
Affinity Capture-MS Homo sapiens
15 TMEM74  
Affinity Capture-MS Homo sapiens
16 SEC62 7095
Affinity Capture-MS Homo sapiens
17 EIF2B5 8893
Affinity Capture-MS Homo sapiens
18 TMEM169  
Affinity Capture-MS Homo sapiens
19 SFXN1 94081
Proximity Label-MS Homo sapiens
20 CHCHD4  
Affinity Capture-MS Homo sapiens
21 RBM4 5936
Affinity Capture-MS Homo sapiens
22 CDHR3  
Affinity Capture-MS Homo sapiens
23 RIPPLY2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 CDH8  
Affinity Capture-MS Homo sapiens
25 TBC1D22A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 ZCCHC10  
Affinity Capture-MS Homo sapiens
27 KRTAP19-4  
Affinity Capture-MS Homo sapiens
28 GPR182  
Affinity Capture-MS Homo sapiens
29 EIF2B2 8892
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 TRDN 10345
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 ZER1 10444
Affinity Capture-MS Homo sapiens
32 CLPB 81570
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 HEATR3 55027
Affinity Capture-MS Homo sapiens
34 EIF2B1 1967
Affinity Capture-MS Homo sapiens
35 PBXIP1 57326
Affinity Capture-MS Homo sapiens
36 SYT2  
Affinity Capture-MS Homo sapiens
37 SLC25A12 8604
Proximity Label-MS Homo sapiens
38 AK9  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 ATP2A3 489
Affinity Capture-MS Homo sapiens
40 C3orf52  
Affinity Capture-MS Homo sapiens
41 C17orf59 54785
Affinity Capture-MS Homo sapiens
42 ATP2A1 487
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which EXOG is involved
No pathways found





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