Gene description for TRDN
Gene name triadin
Gene symbol TRDN
Other names/aliases CPVT5
TDN
TRISK
Species Homo sapiens
 Database cross references - TRDN
ExoCarta ExoCarta_10345
Vesiclepedia VP_10345
Entrez Gene 10345
HGNC 12261
MIM 603283
UniProt Q13061  
 TRDN identified in exosomes derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for TRDN
Molecular Function
    protein binding, bridging GO:0030674 ISS
    receptor binding GO:0005102 IEA
    ion channel binding GO:0044325 ISS
    protein binding GO:0005515 IPI
Biological Process
    ion transmembrane transport GO:0034220 TAS
    heart contraction GO:0060047 IMP
    regulation of cell communication by electrical coupling GO:0010649 TAS
    regulation of cardiac muscle cell membrane potential GO:0086036 ISS
    negative regulation of ryanodine-sensitive calcium-release channel activity GO:0060315 TAS
    cytoplasmic microtubule organization GO:0031122 ISS
    regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010880 ISS
    regulation of release of sequestered calcium ion into cytosol GO:0051279 TAS
    muscle contraction GO:0006936 TAS
    cellular calcium ion homeostasis GO:0006874 ISS
    positive regulation of ryanodine-sensitive calcium-release channel activity GO:0060316 TAS
    release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0014808 ISS
    positive regulation of cell communication by electrical coupling involved in cardiac conduction GO:1901846 ISS
    transmembrane transport GO:0055085 TAS
    endoplasmic reticulum membrane organization GO:0090158 ISS
Subcellular Localization
    cytoplasm GO:0005737 IDA
    junctional sarcoplasmic reticulum membrane GO:0014701 TAS
    endoplasmic reticulum GO:0005783 ISS
    voltage-gated calcium channel complex GO:0005891 ISS
    junctional membrane complex GO:0030314 ISS
    plasma membrane GO:0005886 IDA
    sarcoplasmic reticulum GO:0016529 ISS
    sarcoplasmic reticulum lumen GO:0033018 TAS
    sarcoplasmic reticulum membrane GO:0033017 TAS
    integral component of membrane GO:0016021 TAS
 Experiment description of studies that identified TRDN in exosomes
1
Experiment ID 834
MISEV standards
✔
EM
EV Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for TRDN
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HRC  
Invivo Homo sapiens
Invitro Homo sapiens
Reconstituted Complex Homo sapiens
2 CASQ2 845
Invivo Homo sapiens
Invivo Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
3 RYR1 6261
Invivo Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which TRDN is involved
PathwayEvidenceSource
Stimuli-sensing channels TAS Reactome





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