Gene description for CASQ2
Gene name calsequestrin 2 (cardiac muscle)
Gene symbol CASQ2
Other names/aliases PDIB2
Species Homo sapiens
 Database cross references - CASQ2
ExoCarta ExoCarta_845
Vesiclepedia VP_845
Entrez Gene 845
HGNC 1513
MIM 114251
UniProt O14958  
 CASQ2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for CASQ2
Molecular Function
    calcium-dependent protein binding GO:0048306 IDA
    protein homodimerization activity GO:0042803 ISS
    calcium ion binding GO:0005509 IDA
    protein binding GO:0005515 IPI
Biological Process
    negative regulation of ryanodine-sensitive calcium-release channel activity GO:0060315 ISS
    regulation of membrane repolarization GO:0060306 ISS
    detection of calcium ion GO:0005513 TAS
    Purkinje myocyte to ventricular cardiac muscle cell signaling GO:0086029 NAS
    sequestering of calcium ion GO:0051208 IMP
    transmembrane transport GO:0055085 TAS
    striated muscle contraction GO:0006941 TAS
    cellular response to caffeine GO:0071313 IMP
    regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion GO:0010881 IMP
    negative regulation of potassium ion transport GO:0043267 ISS
    regulation of cell communication by electrical coupling GO:0010649 IMP
    negative regulation of potassium ion transmembrane transporter activity GO:1901017 ISS
    protein polymerization GO:0051258 IDA
    regulation of heart rate GO:0002027 IMP
    ion transmembrane transport GO:0034220 TAS
    cardiac muscle contraction GO:0060048 IMP
    regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010880 ISS
    sarcomere organization GO:0045214 IEA
Subcellular Localization
    intracellular GO:0005622 IMP
    junctional membrane complex GO:0030314 IEA
    sarcoplasmic reticulum lumen GO:0033018 IC
    calcium channel complex GO:0034704 TAS
    Z disc GO:0030018 ISS
    sarcoplasmic reticulum membrane GO:0033017 TAS
    sarcoplasmic reticulum GO:0016529 ISS
    voltage-gated calcium channel complex GO:0005891 ISS
    junctional sarcoplasmic reticulum membrane GO:0014701 TAS
    cytoplasm GO:0005737 IDA
 Experiment description of studies that identified CASQ2 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for CASQ2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TRDN 10345
Invivo Homo sapiens
Invivo Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which CASQ2 is involved
PathwayEvidenceSource
Stimuli-sensing channels TAS Reactome





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