Gene description for MRPL21
Gene name mitochondrial ribosomal protein L21
Gene symbol MRPL21
Other names/aliases L21mt
MRP-L21
Species Homo sapiens
 Database cross references - MRPL21
ExoCarta ExoCarta_219927
Vesiclepedia VP_219927
Entrez Gene 219927
HGNC 14479
MIM 611834
UniProt Q7Z2W9  
 MRPL21 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for MRPL21
Molecular Function
    RNA binding GO:0003723 HDA
    structural constituent of ribosome GO:0003735 IBA
Biological Process
    mitochondrial translation GO:0032543 NAS
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IDA
    mitochondrial inner membrane GO:0005743 NAS
    mitochondrial inner membrane GO:0005743 TAS
    mitochondrial large ribosomal subunit GO:0005762 IBA
    mitochondrial large ribosomal subunit GO:0005762 IDA
    mitochondrial large ribosomal subunit GO:0005762 NAS
 Experiment description of studies that identified MRPL21 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for MRPL21
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MRPL41 64975
Affinity Capture-MS Homo sapiens
2 SLIRP 81892
Proximity Label-MS Homo sapiens
3 H1FNT  
Affinity Capture-MS Homo sapiens
4 GTPBP8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 ZNF346  
Affinity Capture-MS Homo sapiens
6 FBXO33  
Affinity Capture-MS Homo sapiens
7 MRPL30  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 MRPL17  
Affinity Capture-MS Homo sapiens
9 RPA2 6118
Proximity Label-MS Homo sapiens
10 RPL13A 23521
Affinity Capture-MS Homo sapiens
11 TRUB2  
Proximity Label-MS Homo sapiens
12 MTG2  
Proximity Label-MS Homo sapiens
13 NGRN  
Proximity Label-MS Homo sapiens
14 CHCHD1  
Proximity Label-MS Homo sapiens
15 MRPL37 51253
Affinity Capture-MS Homo sapiens
16 MRPL27 51264
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 FDXR 2232
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 MRPL50 54534
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 HARS2 23438
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 MRPL52  
Affinity Capture-MS Homo sapiens
21 RPUSD4 84881
Proximity Label-MS Homo sapiens
22 MRPL49 740
Affinity Capture-MS Homo sapiens
23 DNAJC15  
Proximity Label-MS Homo sapiens
24 MTRF1  
Proximity Label-MS Homo sapiens
25 GFM2 84340
Proximity Label-MS Homo sapiens
26 ILF2 3608
Co-fractionation Homo sapiens
27 LRPPRC 10128
Proximity Label-MS Homo sapiens
28 MRPL20 55052
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 TFAM 7019
Proximity Label-MS Homo sapiens
30 PMPCA 23203
Proximity Label-MS Homo sapiens
31 C8orf82  
Proximity Label-MS Homo sapiens
32 MRPL23 6150
Affinity Capture-MS Homo sapiens
33 HINT2 84681
Proximity Label-MS Homo sapiens
34 DUSP11  
Affinity Capture-MS Homo sapiens
35 MRPL12 6182
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 NPM1 4869
Affinity Capture-MS Homo sapiens
37 KLF15  
Affinity Capture-MS Homo sapiens
38 RPS9 6203
Affinity Capture-MS Homo sapiens
39 MRPS26 64949
Proximity Label-MS Homo sapiens
40 SURF1  
Proximity Label-MS Homo sapiens
41 TRA2A 29896
Affinity Capture-MS Homo sapiens
42 EXD2  
Proximity Label-MS Homo sapiens
43 MRPL39 54148
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 NHP2 55651
Affinity Capture-MS Homo sapiens
45 BTRC 8945
Affinity Capture-MS Homo sapiens
46 PMPCB 9512
Proximity Label-MS Homo sapiens
47 MRPL4 51073
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 FASTKD2  
Proximity Label-MS Homo sapiens
49 PREPL 9581
Affinity Capture-MS Homo sapiens
50 FAF2 23197
Co-fractionation Homo sapiens
51 VWA8 23078
Proximity Label-MS Homo sapiens
52 MRPL47 57129
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 RPL19 6143
Affinity Capture-MS Homo sapiens
54 MTERF3  
Proximity Label-MS Homo sapiens
55 GAR1 54433
Affinity Capture-MS Homo sapiens
56 LIN28A  
Affinity Capture-MS Homo sapiens
57 MDH2 4191
Proximity Label-MS Homo sapiens
58 MRPS30 10884
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 MRPL13  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 MRPL32 64983
Co-fractionation Homo sapiens
61 C6orf203  
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
62 COX15 1355
Proximity Label-MS Homo sapiens
63 FASTKD5  
Proximity Label-MS Homo sapiens
64 MRPL45 84311
Affinity Capture-MS Homo sapiens
65 MALSU1  
Affinity Capture-MS Homo sapiens
66 SRSF3 6428
Affinity Capture-MS Homo sapiens
67 YBX2 51087
Affinity Capture-MS Homo sapiens
68 CPS1 1373
Affinity Capture-MS Homo sapiens
69 TUFM 7284
Proximity Label-MS Homo sapiens
70 ACACA 31
Positive Genetic Homo sapiens
71 HSCB 150274
Proximity Label-MS Homo sapiens
72 NDUFAF5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
73 FOXL2  
Affinity Capture-MS Homo sapiens
74 MRPL18 29074
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 CCDC109B 55013
Proximity Label-MS Homo sapiens
76 TBRG4 9238
Proximity Label-MS Homo sapiens
77 MTFMT  
Proximity Label-MS Homo sapiens
78 MRPL11 65003
Proximity Label-MS Homo sapiens
79 MTRF1L  
Proximity Label-MS Homo sapiens
80 NDUFAF7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
81 TMEM70  
Proximity Label-MS Homo sapiens
82 CYLD  
Affinity Capture-MS Homo sapiens
83 MRPL2 51069
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
84 COX4I1 1327
Proximity Label-MS Homo sapiens
85 GTPBP3  
Affinity Capture-MS Homo sapiens
86 Brwd3  
Affinity Capture-MS Mus musculus
87 MRPL44  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
88 MRPL51 51258
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
89 MRPL40 64976
Co-fractionation Homo sapiens
90 MRRF  
Proximity Label-MS Homo sapiens
91 MRPS12  
Proximity Label-MS Homo sapiens
92 MRPL10 124995
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
93 MTIF2 4528
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
94 MRPL24  
Co-fractionation Homo sapiens
95 NBEA  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
96 CLPP 8192
Proximity Label-MS Homo sapiens
97 MTIF3  
Proximity Label-MS Homo sapiens
98 MRPL9 65005
Affinity Capture-MS Homo sapiens
99 RPL37 6167
Affinity Capture-MS Homo sapiens
100 CUL3 8452
Affinity Capture-MS Homo sapiens
101 ELAC2 60528
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
102 GADD45GIP1  
Affinity Capture-MS Homo sapiens
103 HNRNPA1 3178
Affinity Capture-MS Homo sapiens
104 DHX30 22907
Proximity Label-MS Homo sapiens
105 C17orf80 55028
Proximity Label-MS Homo sapiens
106 TOP3A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
107 C12orf65  
Proximity Label-MS Homo sapiens
108 MYCN  
Affinity Capture-MS Homo sapiens
109 TACO1  
Proximity Label-MS Homo sapiens
110 MYC  
Affinity Capture-MS Homo sapiens
111 ACSF2 80221
Affinity Capture-MS Homo sapiens
112 ACAD9 28976
Proximity Label-MS Homo sapiens
113 MRPL38  
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
114 PUS1 80324
Affinity Capture-MS Homo sapiens
115 METTL15  
Proximity Label-MS Homo sapiens
116 ZC3H3  
Affinity Capture-MS Homo sapiens
117 RBMS2 5939
Affinity Capture-MS Homo sapiens
118 YBX1 4904
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
119 CS 1431
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
120 MRPL42  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
121 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
122 TSFM 10102
Proximity Label-MS Homo sapiens
123 AUH 549
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
124 DNAJC19 131118
Proximity Label-MS Homo sapiens
125 FBXL6  
Affinity Capture-MS Homo sapiens
126 GTPBP6  
Affinity Capture-MS Homo sapiens
127 ICT1 3396
Proximity Label-MS Homo sapiens
128 LONP1 9361
Proximity Label-MS Homo sapiens
129 MRPL53  
Affinity Capture-MS Homo sapiens
130 MRPL43 84545
Affinity Capture-MS Homo sapiens
131 DNAJA3 9093
Proximity Label-MS Homo sapiens
132 MRPL1  
Affinity Capture-MS Homo sapiens
133 ZADH2 284273
Affinity Capture-MS Homo sapiens
134 TRA2B 6434
Affinity Capture-MS Homo sapiens
135 C21orf33  
Proximity Label-MS Homo sapiens
136 SSBP1 6742
Proximity Label-MS Homo sapiens
137 FASTKD3  
Proximity Label-MS Homo sapiens
138 NEIL1  
Affinity Capture-MS Homo sapiens
139 LARS2 23395
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
140 GFM1 85476
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
141 TEFM  
Proximity Label-MS Homo sapiens
142 MRPS9 64965
Co-fractionation Homo sapiens
143 MRPL19 9801
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
144 LIPA 3988
Affinity Capture-MS Homo sapiens
145 RPS8 6202
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
146 GRSF1 2926
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
147 C1QBP 708
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
148 HNRNPU 3192
Affinity Capture-MS Homo sapiens
149 METTL17  
Proximity Label-MS Homo sapiens
150 DARS2 55157
Affinity Capture-MS Homo sapiens
151 MRPL28 10573
Affinity Capture-MS Homo sapiens
152 MRPS18A  
Affinity Capture-MS Homo sapiens
153 DDX28  
Proximity Label-MS Homo sapiens
154 IARS2 55699
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
155 CASQ2 845
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
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