Gene description for MRPL19
Gene name mitochondrial ribosomal protein L19
Gene symbol MRPL19
Other names/aliases L19mt
MRP-L15
MRP-L19
MRPL15
RLX1
RPML15
Species Homo sapiens
 Database cross references - MRPL19
ExoCarta ExoCarta_9801
Vesiclepedia VP_9801
Entrez Gene 9801
HGNC 14052
MIM 611832
UniProt P49406  
 MRPL19 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for MRPL19
Molecular Function
    structural constituent of ribosome GO:0003735 IBA
    protein binding GO:0005515 IPI
Biological Process
    mitochondrial translation GO:0032543 NAS
Subcellular Localization
    nucleus GO:0005634 IDA
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IDA
    mitochondrial inner membrane GO:0005743 NAS
    mitochondrial inner membrane GO:0005743 TAS
    mitochondrial large ribosomal subunit GO:0005762 IBA
    mitochondrial large ribosomal subunit GO:0005762 IDA
    mitochondrial large ribosomal subunit GO:0005762 NAS
 Experiment description of studies that identified MRPL19 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for MRPL19
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Affinity Capture-MS Homo sapiens
2 CDC14B 8555
Affinity Capture-MS Homo sapiens
3 SLIRP 81892
Proximity Label-MS Homo sapiens
4 KIF23 9493
Affinity Capture-MS Homo sapiens
5 NPLOC4 55666
Co-fractionation Homo sapiens
6 RBMS3  
Affinity Capture-MS Homo sapiens
7 MRPL30  
Affinity Capture-MS Homo sapiens
8 MRPL17  
Affinity Capture-MS Homo sapiens
9 RBMS2 5939
Affinity Capture-MS Homo sapiens
10 RPL13A 23521
Affinity Capture-MS Homo sapiens
11 TRUB2  
Proximity Label-MS Homo sapiens
12 NGRN  
Proximity Label-MS Homo sapiens
13 MRPL24  
Co-fractionation Homo sapiens
14 MRPL10 124995
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 MRPL27 51264
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 MRPL50 54534
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
17 TRIM55  
Two-hybrid Homo sapiens
18 MRPL52  
Affinity Capture-MS Homo sapiens
19 RPUSD4 84881
Proximity Label-MS Homo sapiens
20 MRPL49 740
Affinity Capture-MS Homo sapiens
21 DNAJC15  
Proximity Label-MS Homo sapiens
22 MTRF1  
Proximity Label-MS Homo sapiens
23 GFM2 84340
Proximity Label-MS Homo sapiens
24 CCDC90B  
Proximity Label-MS Homo sapiens
25 CENPA  
Affinity Capture-MS Homo sapiens
26 LRPPRC 10128
Proximity Label-MS Homo sapiens
27 MRPL20 55052
Affinity Capture-MS Homo sapiens
28 TFAM 7019
Proximity Label-MS Homo sapiens
29 PMPCA 23203
Proximity Label-MS Homo sapiens
30 MRPL23 6150
Affinity Capture-MS Homo sapiens
31 HINT2 84681
Proximity Label-MS Homo sapiens
32 DUSP11  
Affinity Capture-MS Homo sapiens
33 MRPL12 6182
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 MRPL57  
Co-fractionation Homo sapiens
35 MRPS26 64949
Proximity Label-MS Homo sapiens
36 MALSU1  
Affinity Capture-MS Homo sapiens
37 TRA2A 29896
Affinity Capture-MS Homo sapiens
38 MRPL39 54148
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
39 NHP2 55651
Affinity Capture-MS Homo sapiens
40 MECP2 4204
Affinity Capture-MS Homo sapiens
41 CUL1 8454
Affinity Capture-MS Homo sapiens
42 PMPCB 9512
Proximity Label-MS Homo sapiens
43 MRPL4 51073
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 FASTKD2  
Proximity Label-MS Homo sapiens
45 VWA8 23078
Proximity Label-MS Homo sapiens
46 NEDD4 4734
Reconstituted Complex Homo sapiens
47 MRPL47 57129
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
48 FAM120A 23196
Affinity Capture-MS Homo sapiens
49 MTERF3  
Proximity Label-MS Homo sapiens
50 KIF14 9928
Affinity Capture-MS Homo sapiens
51 MDH2 4191
Proximity Label-MS Homo sapiens
52 MRPS30 10884
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 MRPL13  
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 C6orf203  
Proximity Label-MS Homo sapiens
55 TSR1 55720
Co-fractionation Homo sapiens
56 FASTKD5  
Proximity Label-MS Homo sapiens
57 MRPL45 84311
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
58 TMEM177  
Co-fractionation Homo sapiens
59 SRSF3 6428
Affinity Capture-MS Homo sapiens
60 YBX2 51087
Affinity Capture-MS Homo sapiens
61 TUFM 7284
Proximity Label-MS Homo sapiens
62 MAGEC1  
Two-hybrid Homo sapiens
63 HSCB 150274
Proximity Label-MS Homo sapiens
64 NTRK1 4914
Affinity Capture-MS Homo sapiens
65 GFM1 85476
Proximity Label-MS Homo sapiens
66 MRPL3  
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
67 MTFMT  
Proximity Label-MS Homo sapiens
68 MRPL11 65003
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
69 MTRF1L  
Proximity Label-MS Homo sapiens
70 TMEM70  
Proximity Label-MS Homo sapiens
71 TRIM63  
Two-hybrid Homo sapiens
72 MRPL2 51069
Affinity Capture-MS Homo sapiens
73 MRPL41 64975
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 Ppp2r1a 51792
Affinity Capture-MS Mus musculus
75 HNRNPDL 9987
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
76 MRPL14 64928
Co-fractionation Homo sapiens
77 MRPL44  
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
78 MRPL51 51258
Affinity Capture-MS Homo sapiens
79 MRPL40 64976
Co-fractionation Homo sapiens
80 MRPL21 219927
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
81 MRRF  
Proximity Label-MS Homo sapiens
82 MRPS12  
Proximity Label-MS Homo sapiens
83 MTIF2 4528
Proximity Label-MS Homo sapiens
84 CLPP 8192
Proximity Label-MS Homo sapiens
85 H1FNT  
Affinity Capture-MS Homo sapiens
86 MTIF3  
Proximity Label-MS Homo sapiens
87 MRPL9 65005
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
88 MRPL16  
Co-fractionation Homo sapiens
89 PRKCZ 5590
Affinity Capture-MS Homo sapiens
90 CUL3 8452
Affinity Capture-MS Homo sapiens
91 EGFR 1956
Negative Genetic Homo sapiens
92 GADD45GIP1  
Affinity Capture-MS Homo sapiens
93 HNRNPA1 3178
Affinity Capture-MS Homo sapiens
94 Max  
Affinity Capture-MS Mus musculus
95 MRPL15 29088
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
96 MRPL1  
Affinity Capture-MS Homo sapiens
97 MYCN  
Affinity Capture-MS Homo sapiens
98 TACO1  
Proximity Label-MS Homo sapiens
99 MTG1  
Proximity Label-MS Homo sapiens
100 MYC  
Affinity Capture-MS Homo sapiens
101 RPA3 6119
Proximity Label-MS Homo sapiens
102 MRPL37 51253
Affinity Capture-MS Homo sapiens
103 NEDD4L 23327
Reconstituted Complex Homo sapiens
104 ACAD9 28976
Proximity Label-MS Homo sapiens
105 MATR3 9782
Co-fractionation Homo sapiens
106 SRSF10 10772
Affinity Capture-MS Homo sapiens
107 CAND1 55832
Affinity Capture-MS Homo sapiens
108 MRPL38  
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
109 HIST1H1T 3010
Affinity Capture-MS Homo sapiens
110 METTL15  
Proximity Label-MS Homo sapiens
111 ZC3H3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
112 MRPL18 29074
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
113 SOX2  
Affinity Capture-MS Homo sapiens
114 Smchd1  
Affinity Capture-MS Mus musculus
115 APP 351
Reconstituted Complex Homo sapiens
116 YBX1 4904
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
117 CS 1431
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
118 MRPL42  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
119 FBXW11  
Affinity Capture-MS Homo sapiens
120 TSFM 10102
Proximity Label-MS Homo sapiens
121 AUH 549
Proximity Label-MS Homo sapiens
122 ICT1 3396
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Co-fractionation Homo sapiens
123 SRSF9 8683
Affinity Capture-MS Homo sapiens
124 MRPL53  
Affinity Capture-MS Homo sapiens
125 MRPL43 84545
Affinity Capture-MS Homo sapiens
126 PDHA1 5160
Proximity Label-MS Homo sapiens
127 C12orf65  
Proximity Label-MS Homo sapiens
128 COX8A  
Proximity Label-MS Homo sapiens
129 TRA2B 6434
Affinity Capture-MS Homo sapiens
130 C21orf33  
Proximity Label-MS Homo sapiens
131 SSBP1 6742
Proximity Label-MS Homo sapiens
132 TBRG4 9238
Proximity Label-MS Homo sapiens
133 AARS2  
Proximity Label-MS Homo sapiens
134 TEFM  
Proximity Label-MS Homo sapiens
135 RPS8 6202
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
136 GRSF1 2926
Proximity Label-MS Homo sapiens
137 C1QBP 708
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
138 METTL17  
Proximity Label-MS Homo sapiens
139 MRPL28 10573
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
140 PRMT1 3276
Affinity Capture-MS Homo sapiens
141 MRPS18A  
Affinity Capture-MS Homo sapiens
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