Gene description for MRPL2
Gene name mitochondrial ribosomal protein L2
Gene symbol MRPL2
Other names/aliases CGI-22
MRP-L14
RPML14
Species Homo sapiens
 Database cross references - MRPL2
ExoCarta ExoCarta_51069
Entrez Gene 51069
HGNC 14056
MIM 611822
UniProt Q5T653  
 MRPL2 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for MRPL2
Molecular Function
    poly(A) RNA binding GO:0044822 IDA
    structural constituent of ribosome GO:0003735 IEA
Biological Process
    mitochondrial translational initiation GO:0070124 TAS
    organelle organization GO:0006996 TAS
    mitochondrial translation GO:0032543 TAS
    mitochondrial translational elongation GO:0070125 TAS
    mitochondrial translational termination GO:0070126 TAS
Subcellular Localization
    mitochondrial inner membrane GO:0005743 TAS
    ribosome GO:0005840 IEA
 Experiment description of studies that identified MRPL2 in exosomes
1
Experiment ID 235
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for MRPL2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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