Gene description for COX1
Gene name mitochondrially encoded cytochrome c oxidase I
Gene symbol COX1
Other names/aliases COI
MTCO1
Species Homo sapiens
 Database cross references - COX1
ExoCarta ExoCarta_4512
Vesiclepedia VP_4512
Entrez Gene 4512
HGNC 7419
MIM 516030
UniProt P00395  
 COX1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for COX1
Molecular Function
    cytochrome-c oxidase activity GO:0004129 IBA
    cytochrome-c oxidase activity GO:0004129 IMP
    protein binding GO:0005515 IPI
    heme binding GO:0020037 IEA
    metal ion binding GO:0046872 IEA
Biological Process
    response to hypoxia GO:0001666 IEA
    mitochondrial electron transport, cytochrome c to oxygen GO:0006123 NAS
    response to oxidative stress GO:0006979 IEA
    aerobic respiration GO:0009060 IBA
    cerebellum development GO:0021549 IEA
    respiratory electron transport chain GO:0022904 IBA
    cellular respiration GO:0045333 NAS
    response to copper ion GO:0046688 IEA
    response to electrical stimulus GO:0051602 IEA
    proton transmembrane transport GO:1902600 IEA
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrial inner membrane GO:0005743 TAS
    mitochondrial membrane GO:0031966 IDA
    respiratory chain complex IV GO:0045277 IBA
    respiratory chain complex IV GO:0045277 IDA
    respiratory chain complex IV GO:0045277 IMP
 Experiment description of studies that identified COX1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for COX1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RNF149 284996
Affinity Capture-MS Homo sapiens
2 COX7A1  
Affinity Capture-MS Homo sapiens
3 GRPR  
Affinity Capture-MS Homo sapiens
4 HTR1B  
Affinity Capture-MS Homo sapiens
5 LIG4 3981
Two-hybrid Homo sapiens
6 SNCA 6622
Protein-peptide Homo sapiens
7 C5AR1  
Affinity Capture-MS Homo sapiens
8 NDUFB8 4714
Affinity Capture-Western Homo sapiens
9 SLC15A1  
Affinity Capture-MS Homo sapiens
10 GPR141  
Affinity Capture-MS Homo sapiens
11 EDNRA 1909
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 UQCRQ 27089
Affinity Capture-MS Homo sapiens
13 PRDX4 10549
Two-hybrid Homo sapiens
14 GPR17 2840
Affinity Capture-MS Homo sapiens
15 Hoxa1  
Two-hybrid Mus musculus
16 COX4I2 84701
Affinity Capture-MS Homo sapiens
17 HSPB2  
Two-hybrid Homo sapiens
18 C19orf38  
Affinity Capture-MS Homo sapiens
19 ASGR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 COX5A 9377
Affinity Capture-MS Homo sapiens
21 TSPAN15 23555
Affinity Capture-MS Homo sapiens
22 GCGR  
Affinity Capture-MS Homo sapiens
23 UQCRB 7381
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 CACNG6  
Affinity Capture-MS Homo sapiens
25 P2RY8  
Affinity Capture-MS Homo sapiens
26 FFAR1  
Affinity Capture-MS Homo sapiens
27 SLC22A9  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 COMTD1 118881
Affinity Capture-MS Homo sapiens
29 CDC42 998
Two-hybrid Homo sapiens
30 COX14  
Affinity Capture-Western Homo sapiens
31 GPR52  
Affinity Capture-MS Homo sapiens
32 UXS1 80146
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 CLEC4G  
Two-hybrid Homo sapiens
34 SLC5A8 160728
Affinity Capture-MS Homo sapiens
35 SPPL2B 56928
Affinity Capture-MS Homo sapiens
36 COX2 4513
Affinity Capture-Western Homo sapiens
37 GPR45  
Affinity Capture-MS Homo sapiens
38 FAM134C 162427
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 IL27RA 9466
Affinity Capture-MS Homo sapiens
40 TACR1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 MEOX2  
Two-hybrid Homo sapiens
42 OPRM1 4988
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 COA3 28958
Affinity Capture-Western Homo sapiens
44 COX7C 1350
Affinity Capture-MS Homo sapiens
45 MRPL2 51069
Affinity Capture-MS Homo sapiens
46 VIPR1  
Affinity Capture-MS Homo sapiens
47 COX6A1  
Affinity Capture-MS Homo sapiens
48 NTSR1  
Affinity Capture-MS Homo sapiens
49 COX7B2  
Affinity Capture-MS Homo sapiens
50 MLNR  
Affinity Capture-MS Homo sapiens
51 ATP5C1 509
Affinity Capture-MS Homo sapiens
52 MRPL18 29074
Affinity Capture-MS Homo sapiens
53 P2RY12 64805
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 APLNR  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 COX4I1 1327
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml



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