Gene description for OPRM1
Gene name opioid receptor, mu 1
Gene symbol OPRM1
Other names/aliases LMOR
Species Homo sapiens
 Database cross references - OPRM1
ExoCarta ExoCarta_4988
Entrez Gene 4988
HGNC 8156
MIM 600018
UniProt P35372  
 OPRM1 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for OPRM1
Molecular Function
    protein domain specific binding GO:0019904 IEA
    filamin binding GO:0031005 IEA
    morphine receptor activity GO:0038047 ISS
    G-protein coupled receptor activity GO:0004930 ISS
    G-protein beta-subunit binding GO:0031681 IBA
    protein binding GO:0005515 IPI
    neuropeptide binding GO:0042923 IBA
    beta-endorphin receptor activity GO:0004979 IMP
    voltage-gated calcium channel activity GO:0005245 ISS
    G-protein alpha-subunit binding GO:0001965 IDA
Biological Process
    adenylate cyclase-activating dopamine receptor signaling pathway GO:0007191 IEA
    sensory perception GO:0007600 NAS
    negative regulation of adenylate cyclase activity GO:0007194 ISS
    cellular response to stress GO:0033554 IMP
    response to food GO:0032094 IEA
    negative regulation of cytosolic calcium ion concentration GO:0051481 IDA
    neuropeptide signaling pathway GO:0007218 IMP
    positive regulation of neurogenesis GO:0050769 ISS
    regulation of sensory perception of pain GO:0051930 IEA
    synaptic transmission GO:0007268 IBA
    negative regulation of nitric oxide biosynthetic process GO:0045019 IDA
    positive regulation of nitric oxide biosynthetic process GO:0045429 IDA
    sensory perception of pain GO:0019233 ISS
    negative regulation of cell proliferation GO:0008285 TAS
    response to growth factor GO:0070848 IEA
    regulation of N-methyl-D-aspartate selective glutamate receptor activity GO:2000310 ISS
    positive regulation of cAMP-mediated signaling GO:0043950 IDA
    cellular response to morphine GO:0071315 IBA
    negative regulation of Wnt protein secretion GO:0061358 IMP
    adenylate cyclase-inhibiting opioid receptor signaling pathway GO:0031635 IEA
    locomotory behavior GO:0007626 IEA
    response to cocaine GO:0042220 IEA
    positive regulation of ERK1 and ERK2 cascade GO:0070374 ISS
    positive regulation of cytosolic calcium ion concentration GO:0007204 IDA
    calcium ion transmembrane transport GO:0070588 IEA
    opioid receptor signaling pathway GO:0038003 IBA
    acute inflammatory response to antigenic stimulus GO:0002438 IEA
    G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 TAS
    negative regulation of cAMP-mediated signaling GO:0043951 IDA
    regulation of excitatory postsynaptic membrane potential GO:0060079 IEA
    positive regulation of appetite GO:0032100 IEA
    response to lipopolysaccharide GO:0032496 IEA
    behavioral response to ethanol GO:0048149 IMP
    wound healing GO:0042060 IEA
    phospholipase C-activating G-protein coupled receptor signaling pathway GO:0007200 ISS
Subcellular Localization
    neuron projection GO:0043005 IBA
    dendrite cytoplasm GO:0032839 IEA
    perikaryon GO:0043204 IEA
    integral component of plasma membrane GO:0005887 TAS
    focal adhesion GO:0005925 IEA
    plasma membrane GO:0005886 TAS
    Golgi apparatus GO:0005794 TAS
    cytosol GO:0005829 IDA
    dendrite membrane GO:0032590 IEA
    endoplasmic reticulum GO:0005783 TAS
    sarcolemma GO:0042383 IEA
    membrane raft GO:0045121 IEA
 Experiment description of studies that identified OPRM1 in exosomes
Experiment ID 126
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for OPRM1
  Protein Interactor ExoCarta ID Identification method PubMed Species
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
2 GNAI2 2771
Invivo Homo sapiens
3 OPRD1  
Affinity Capture-Western Homo sapiens
4 CALM1 801
Reconstituted Complex Homo sapiens
5 PLD2 5338
Invivo Homo sapiens
Invitro Homo sapiens
6 GNAO1 2775
Invivo Homo sapiens
7 GNAI1 2770
Invivo Homo sapiens
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