Gene description for MFF
Gene name mitochondrial fission factor
Gene symbol MFF
Other names/aliases C2orf33
GL004
Species Homo sapiens
 Database cross references - MFF
ExoCarta ExoCarta_56947
Entrez Gene 56947
HGNC 24858
MIM 614785
UniProt Q9GZY8  
 MFF identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for MFF
Molecular Function
    protein binding GO:0005515 IPI
    protein homodimerization activity GO:0042803 IDA
Biological Process
    mitochondrial fragmentation involved in apoptotic process GO:0043653 IMP
    positive regulation of release of cytochrome c from mitochondria GO:0090200 IMP
    regulation of mitochondrion organization GO:0010821 IMP
    mitochondrion morphogenesis GO:0070584 IMP
    regulation of peroxisome organization GO:1900063 IMP
    release of cytochrome c from mitochondria GO:0001836 IMP
    mitochondrial fission GO:0000266 ISS
    protein targeting to mitochondrion GO:0006626 IMP
    protein homooligomerization GO:0051260 IDA
    peroxisome fission GO:0016559 IMP
    mitochondrial fusion GO:0008053 IMP
    positive regulation of protein targeting to membrane GO:0090314 IDA
    positive regulation of mitochondrial fission GO:0090141 IDA
Subcellular Localization
    cell junction GO:0030054 IEA
    mitochondrial outer membrane GO:0005741 IDA
    synaptic vesicle GO:0008021 IEA
    integral component of mitochondrial membrane GO:0032592 IDA
    peroxisome GO:0005777 IDA
 Experiment description of studies that identified MFF in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for MFF
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which MFF is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here