Gene description for SMIM1
Gene name small integral membrane protein 1 (Vel blood group)
Gene symbol SMIM1
Other names/aliases Vel
Species Homo sapiens
 Database cross references - SMIM1
ExoCarta ExoCarta_388588
Vesiclepedia VP_388588
Entrez Gene 388588
HGNC 44204
MIM 615242
UniProt B2RUZ4  
 SMIM1 identified in sEVs derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for SMIM1
Molecular Function
    protein binding GO:0005515 IPI
    protein homodimerization activity GO:0042803 IDA
Subcellular Localization
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 IMP
    cell surface GO:0009986 IDA
    cell surface GO:0009986 IMP
 Experiment description of studies that identified SMIM1 in sEVs
1
Experiment ID 834
MISEV standards
EM
Biophysical techniques
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
EM
Biophysical techniques
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for SMIM1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TMEM173  
Two-hybrid Homo sapiens
2 TMEM52B 120939
Two-hybrid Homo sapiens
3 LRP10 26020
Two-hybrid Homo sapiens
4 GJA8  
Two-hybrid Homo sapiens
5 KIR2DL3  
Two-hybrid Homo sapiens
6 SDC3  
Two-hybrid Homo sapiens
7 FNDC9  
Two-hybrid Homo sapiens
8 SLC10A6  
Two-hybrid Homo sapiens
9 ASZ1  
Two-hybrid Homo sapiens
10 NDUFAF2  
Two-hybrid Homo sapiens
11 HACD2 201562
Two-hybrid Homo sapiens
12 TM4SF19  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
13 FCER1G 2207
Two-hybrid Homo sapiens
14 ERGIC3 51614
Two-hybrid Homo sapiens
15 MUC1 4582
Two-hybrid Homo sapiens
16 TMEM51 55092
Two-hybrid Homo sapiens
17 RELL2  
Two-hybrid Homo sapiens
18 LRRC4C  
Two-hybrid Homo sapiens
19 REEP4  
Two-hybrid Homo sapiens
20 EBP  
Two-hybrid Homo sapiens
21 HSD17B13  
Two-hybrid Homo sapiens
22 LHFPL5  
Two-hybrid Homo sapiens
23 JAGN1 84522
Two-hybrid Homo sapiens
24 CREB3L1  
Two-hybrid Homo sapiens
25 TMEM86B  
Two-hybrid Homo sapiens
26 MFSD6 54842
Two-hybrid Homo sapiens
27 FAM209A 200232
Two-hybrid Homo sapiens
28 ANKS6 203286
Two-hybrid Homo sapiens
29 TMEM154  
Two-hybrid Homo sapiens
30 TMPRSS2 7113
Two-hybrid Homo sapiens
31 FAM134C 162427
Two-hybrid Homo sapiens
32 STX1A 6804
Two-hybrid Homo sapiens
33 SIGLEC7  
Two-hybrid Homo sapiens
34 FAM174A 345757
Two-hybrid Homo sapiens
35 SLC26A11 284129
Two-hybrid Homo sapiens
36 TMEM45B 120224
Two-hybrid Homo sapiens
37 CISD2 493856
Two-hybrid Homo sapiens
38 TMX2 51075
Two-hybrid Homo sapiens
39 TMEM31  
Two-hybrid Homo sapiens
40 SCN3B  
Two-hybrid Homo sapiens
41 MFF 56947
Two-hybrid Homo sapiens
42 GJB5  
Two-hybrid Homo sapiens
43 ZDHHC15 158866
Two-hybrid Homo sapiens
44 FAM210B  
Two-hybrid Homo sapiens
45 FFAR2  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which SMIM1 is involved
No pathways found





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