Gene description for ERGIC3
Gene name ERGIC and golgi 3
Gene symbol ERGIC3
Other names/aliases C20orf47
CGI-54
Erv46
NY-BR-84
PRO0989
SDBCAG84
dJ477O4.2
Species Homo sapiens
 Database cross references - ERGIC3
ExoCarta ExoCarta_51614
Vesiclepedia VP_51614
Entrez Gene 51614
HGNC 15927
UniProt Q9Y282  
 ERGIC3 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for ERGIC3
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    endoplasmic reticulum to Golgi vesicle-mediated transport GO:0006888 IBA
    endoplasmic reticulum to Golgi vesicle-mediated transport GO:0006888 IDA
    retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum GO:0006890 IBA
    retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum GO:0006890 NAS
    positive regulation of intracellular protein transport GO:0090316 IMP
Subcellular Localization
    Golgi membrane GO:0000139 IBA
    endoplasmic reticulum GO:0005783 IBA
    endoplasmic reticulum membrane GO:0005789 IBA
    membrane GO:0016020 HDA
    COPII-coated ER to Golgi transport vesicle GO:0030134 IBA
    endoplasmic reticulum-Golgi intermediate compartment membrane GO:0033116 IEA
    retrograde transporter complex, Golgi to ER GO:0061852 IPI
    transporter complex GO:1990351 IPI
 Experiment description of studies that identified ERGIC3 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for ERGIC3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HMP19  
Affinity Capture-MS Homo sapiens
2 STARD3NL 83930
Affinity Capture-MS Homo sapiens
3 PAQR7  
Two-hybrid Homo sapiens
4 SLC16A13 201232
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 TMEM14B  
Two-hybrid Homo sapiens
6 TM4SF4  
Two-hybrid Homo sapiens
7 GPR151  
Two-hybrid Homo sapiens
8 DNAJC11 55735
Affinity Capture-MS Homo sapiens
9 SLC35A1 10559
Two-hybrid Homo sapiens
10 STATH  
Two-hybrid Homo sapiens
11 VTI1B 10490
Two-hybrid Homo sapiens
12 CHRNA4  
Affinity Capture-MS Homo sapiens
13 MFAP3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 NRG4  
Two-hybrid Homo sapiens
15 GIMAP5  
Two-hybrid Homo sapiens
16 SYNGR1 9145
Affinity Capture-MS Homo sapiens
17 TMEM222 84065
Two-hybrid Homo sapiens
18 MIP  
Two-hybrid Homo sapiens
19 EMP1  
Two-hybrid Homo sapiens
20 FA2H  
Two-hybrid Homo sapiens
21 EXTL1  
Two-hybrid Homo sapiens
22 CCR4 1233
Two-hybrid Homo sapiens
23 SMIM1 388588
Two-hybrid Homo sapiens
24 DOLK 22845
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 VMP1 81671
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 BSCL2  
Affinity Capture-MS Homo sapiens
27 TMEM203  
Two-hybrid Homo sapiens
28 CYB561D2 11068
Two-hybrid Homo sapiens
29 AIG1  
Two-hybrid Homo sapiens
30 MTFP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 TMEM186  
Affinity Capture-MS Homo sapiens
32 VSTM1  
Two-hybrid Homo sapiens
33 VAMP2 6844
Two-hybrid Homo sapiens
34 SGPP1 81537
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 NINJ2  
Two-hybrid Homo sapiens
36 GPR114  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 C4orf3  
Two-hybrid Homo sapiens
38 TRAPPC5 126003
Affinity Capture-MS Homo sapiens
39 PSEN2 5664
Affinity Capture-MS Homo sapiens
40 APOD 347
Two-hybrid Homo sapiens
41 COX20  
Two-hybrid Homo sapiens
42 GJB2  
Two-hybrid Homo sapiens
43 TOMM22 56993
Co-fractionation Homo sapiens
44 APEX1 328
Affinity Capture-RNA Homo sapiens
45 SLC13A3 64849
Two-hybrid Homo sapiens
46 SLC29A2 3177
Two-hybrid Homo sapiens
47 AQP3  
Two-hybrid Homo sapiens
48 ALG10  
Two-hybrid Homo sapiens
49 ALG3 10195
Affinity Capture-MS Homo sapiens
50 CTXN3  
Two-hybrid Homo sapiens
51 TMEM65 157378
Two-hybrid Homo sapiens
52 STX8 9482
Two-hybrid Homo sapiens
53 APOC3 345
Two-hybrid Homo sapiens
54 PTPMT1 114971
Affinity Capture-MS Homo sapiens
55 CCR2  
Two-hybrid Homo sapiens
56 SLC41A1 254428
Two-hybrid Homo sapiens
57 TMEM86A  
Two-hybrid Homo sapiens
58 NR2F2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 C2orf82  
Two-hybrid Homo sapiens
60 TMED2 10959
Affinity Capture-MS Homo sapiens
61 BDH1 622
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 CPSF7 79869
Co-fractionation Homo sapiens
63 CFHR5  
Two-hybrid Homo sapiens
64 TMEM184B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 SELK  
Two-hybrid Homo sapiens
66 YIPF3 25844
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 SSR1 6745
Affinity Capture-MS Homo sapiens
68 MARCH5  
Two-hybrid Homo sapiens
69 RER1 11079
Affinity Capture-MS Homo sapiens
70 GIMAP1  
Two-hybrid Homo sapiens
71 TSPO2  
Two-hybrid Homo sapiens
72 LPAR3  
Two-hybrid Homo sapiens
73 C3orf52  
Two-hybrid Homo sapiens
74 NEU1 4758
Two-hybrid Homo sapiens
75 TMEM97 27346
Two-hybrid Homo sapiens
76 TMEM192 201931
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
77 HSD17B2 3294
Affinity Capture-MS Homo sapiens
78 SLC35B4  
Two-hybrid Homo sapiens
79 F2RL1  
Two-hybrid Homo sapiens
80 SMAGP  
Two-hybrid Homo sapiens
81 BET1 10282
Two-hybrid Homo sapiens
82 SLC30A9 10463
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
83 SEC23A 10484
Two-hybrid Homo sapiens
84 TMEM107 84314
Two-hybrid Homo sapiens
85 MS4A13  
Two-hybrid Homo sapiens
86 BUD31 8896
Two-hybrid Homo sapiens
87 JAGN1 84522
Two-hybrid Homo sapiens
88 FAM20C 56975
Affinity Capture-MS Homo sapiens
89 STX12 23673
Two-hybrid Homo sapiens
90 TMEM87A 25963
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
91 ATP1A3 478
Affinity Capture-MS Homo sapiens
92 CCDC167  
Two-hybrid Homo sapiens
93 PAM16  
Affinity Capture-MS Homo sapiens
94 PXMP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
95 YIPF6 286451
Two-hybrid Homo sapiens
96 KCNK1  
Two-hybrid Homo sapiens
97 FAM96A  
Two-hybrid Homo sapiens
98 VKORC1L1 154807
Two-hybrid Homo sapiens
99 HS2ST1 9653
Affinity Capture-MS Homo sapiens
100 CX3CL1  
Affinity Capture-MS Homo sapiens
101 TMEM229B  
Two-hybrid Homo sapiens
102 FAM3C 10447
Two-hybrid Homo sapiens
103 TSPAN33 340348
Two-hybrid Homo sapiens
104 NSG1  
Two-hybrid Homo sapiens
105 IGFBP5 3488
Two-hybrid Homo sapiens
106 IFITM3 10410
Two-hybrid Homo sapiens
107 COPE 11316
Affinity Capture-MS Homo sapiens
108 STOM 2040
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
109 EMP3 2014
Two-hybrid Homo sapiens
110 COPG1 22820
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
111 CYP4F2  
Two-hybrid Homo sapiens
112 MFSD6 54842
Two-hybrid Homo sapiens
113 TMEM100 55273
Two-hybrid Homo sapiens
114 GPR35  
Two-hybrid Homo sapiens
115 SEC22B 9554
Two-hybrid Homo sapiens
116 AGTRAP 57085
Two-hybrid Homo sapiens
117 CLDND2  
Two-hybrid Homo sapiens
118 CHRNB2  
Affinity Capture-MS Homo sapiens
119 CHPT1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
120 THBD 7056
Two-hybrid Homo sapiens
121 ZDHHC15 158866
Two-hybrid Homo sapiens
122 YIF1A 10897
Two-hybrid Homo sapiens
123 C16orf58 64755
Two-hybrid Homo sapiens
124 SYNJ2BP 55333
Two-hybrid Homo sapiens
125 OGT 8473
Reconstituted Complex Homo sapiens
126 TMEM243  
Two-hybrid Homo sapiens
127 GPR182  
Affinity Capture-MS Homo sapiens
128 GK  
Affinity Capture-MS Homo sapiens
129 TRIM32 22954
Two-hybrid Homo sapiens
130 VAMP1 6843
Two-hybrid Homo sapiens
131 SLC25A17 10478
Affinity Capture-MS Homo sapiens
132 SPN 6693
Two-hybrid Homo sapiens
133 CLDN19  
Two-hybrid Homo sapiens
134 LHFPL5  
Two-hybrid Homo sapiens
135 SLC25A46 91137
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
136 MFF 56947
Two-hybrid Homo sapiens
137 CEBPA  
Protein-peptide Homo sapiens
138 ANKRD13A 88455
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
139 CHRND  
Affinity Capture-MS Homo sapiens
140 TRAM1L1  
Two-hybrid Homo sapiens
141 CDIPT 10423
Two-hybrid Homo sapiens
142 UPK2 7379
Affinity Capture-MS Homo sapiens
143 TMEM60  
Two-hybrid Homo sapiens
144 CDS2 8760
Two-hybrid Homo sapiens
145 MYADM 91663
Two-hybrid Homo sapiens
146 TMEM128  
Two-hybrid Homo sapiens
147 FXYD2 486
Two-hybrid Homo sapiens
148 SLC22A6 9356
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
149 AQP2 359
Two-hybrid Homo sapiens
150 RHAG  
Two-hybrid Homo sapiens
151 EMC6 83460
Two-hybrid Homo sapiens
152 CANX 821
Affinity Capture-MS Homo sapiens
153 SLC41A2 84102
Two-hybrid Homo sapiens
154 ZFPL1 7542
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
155 CALR3  
Proximity Label-MS Homo sapiens
156 RTP2  
Two-hybrid Homo sapiens
157 GYPA  
Two-hybrid Homo sapiens
158 CXorf66  
Two-hybrid Homo sapiens
159 DEFB103B  
Two-hybrid Homo sapiens
160 TMEM223  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
161 HMOX2 3163
Two-hybrid Homo sapiens
162 GAST  
Two-hybrid Homo sapiens
163 P2RY2 5029
Affinity Capture-MS Homo sapiens
164 SLC26A2 1836
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
165 YIPF2 78992
Two-hybrid Homo sapiens
166 MFSD7  
Two-hybrid Homo sapiens
167 ANKRD13D  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
168 C14orf180  
Two-hybrid Homo sapiens
169 FKBP8 23770
Two-hybrid Homo sapiens
170 CLDN8  
Two-hybrid Homo sapiens
171 NRM 11270
Two-hybrid Homo sapiens
172 CD207  
Two-hybrid Homo sapiens
173 HSD17B13  
Affinity Capture-MS Homo sapiens
174 FXYD6  
Two-hybrid Homo sapiens
175 TMEM246 84302
Affinity Capture-MS Homo sapiens
176 LPAR1 1902
Affinity Capture-MS Homo sapiens
177 PLLP  
Two-hybrid Homo sapiens
178 ORMDL1 94101
Two-hybrid Homo sapiens
179 TMEM42  
Two-hybrid Homo sapiens
180 SLC35B2 347734
Two-hybrid Homo sapiens
181 SLC38A10 124565
Affinity Capture-MS Homo sapiens
182 SERP2  
Two-hybrid Homo sapiens
183 NDRG4 65009
Two-hybrid Homo sapiens
184 CD81 975
Two-hybrid Homo sapiens
185 TOMM6  
Two-hybrid Homo sapiens
186 FBXO6 26270
Affinity Capture-MS Homo sapiens
187 SLC35A4  
Two-hybrid Homo sapiens
188 SFXN5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
189 COL4A5  
Two-hybrid Homo sapiens
190 GPR45  
Affinity Capture-MS Homo sapiens
191 CMTM5  
Two-hybrid Homo sapiens
192 FAR2  
Affinity Capture-MS Homo sapiens
193 YIPF4 84272
Two-hybrid Homo sapiens
194 NDUFB6 4712
Two-hybrid Homo sapiens
195 AQP10  
Two-hybrid Homo sapiens
196 CLPTM1 1209
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
197 PMP22  
Two-hybrid Homo sapiens
198 SLC22A15  
Affinity Capture-MS Homo sapiens
199 TMEM141  
Two-hybrid Homo sapiens
200 ORMDL3 94103
Two-hybrid Homo sapiens
201 ENTPD3  
Two-hybrid Homo sapiens
202 ENPP7 339221
Affinity Capture-MS Homo sapiens
203 SYS1  
Two-hybrid Homo sapiens
204 BNIP3 664
Two-hybrid Homo sapiens
205 PARL  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
206 GPR37  
Two-hybrid Homo sapiens
207 SLC25A6 293
Affinity Capture-MS Homo sapiens
208 PPP2R5A 5525
Affinity Capture-MS Homo sapiens
209 NKG7  
Two-hybrid Homo sapiens
210 FAXDC2  
Two-hybrid Homo sapiens
211 PPAPDC1A  
Two-hybrid Homo sapiens
212 TAP1 6890
Two-hybrid Homo sapiens
213 CCR8  
Two-hybrid Homo sapiens
214 ITGAM 3684
Two-hybrid Homo sapiens
215 TUSC5  
Two-hybrid Homo sapiens
216 FIS1 51024
Two-hybrid Homo sapiens
217 TMEM218  
Two-hybrid Homo sapiens
218 PAQR5  
Two-hybrid Homo sapiens
219 FLVCR1 28982
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
220 LMBRD2 92255
Affinity Capture-MS