Gene description for LPAR2
Gene name lysophosphatidic acid receptor 2
Gene symbol LPAR2
Other names/aliases EDG-4
EDG4
LPA-2
LPA2
Species Homo sapiens
 Database cross references - LPAR2
ExoCarta ExoCarta_9170
Vesiclepedia VP_9170
Entrez Gene 9170
HGNC 3168
MIM 605110
UniProt Q9HBW0  
 LPAR2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for LPAR2
Molecular Function
    G protein-coupled receptor activity GO:0004930 IBA
    protein binding GO:0005515 IPI
    lipid binding GO:0008289 TAS
    PDZ domain binding GO:0030165 IEA
    lysophosphatidic acid receptor activity GO:0070915 IEA
Biological Process
    G protein-coupled receptor signaling pathway GO:0007186 IDA
    adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 IBA
    positive regulation of cytosolic calcium ion concentration GO:0007204 TAS
    regulation of metabolic process GO:0019222 IBA
    positive regulation of Rho protein signal transduction GO:0035025 IEA
    positive regulation of MAPK cascade GO:0043410 IEA
Subcellular Localization
    cytoplasm GO:0005737 IBA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 TAS
    cell surface GO:0009986 IDA
    endocytic vesicle GO:0030139 IDA
    presynaptic active zone membrane GO:0048787 IEA
    glutamatergic synapse GO:0098978 IEA
 Experiment description of studies that identified LPAR2 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for LPAR2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PAQR7  
Affinity Capture-MS Homo sapiens
2 STARD3NL 83930
Affinity Capture-MS Homo sapiens
3 Slc9a3r2  
Reconstituted Complex Rattus norvegicus
4 SGCA  
Affinity Capture-MS Homo sapiens
5 HBB 3043
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 CMTM6 54918
Affinity Capture-MS Homo sapiens
7 DERL2 51009
Affinity Capture-MS Homo sapiens
8 DHCR24 1718
Affinity Capture-MS Homo sapiens
9 SACM1L 22908
Affinity Capture-MS Homo sapiens
10 TTYH3 80727
Affinity Capture-MS Homo sapiens
11 GALNT1 2589
Affinity Capture-MS Homo sapiens
12 SLC39A4 55630
Affinity Capture-MS Homo sapiens
13 ARL6IP5 10550
Affinity Capture-MS Homo sapiens
14 KIAA2013 90231
Affinity Capture-MS Homo sapiens
15 SIVA1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
16 SURF4 6836
Affinity Capture-MS Homo sapiens
17 PTPN1 5770
Affinity Capture-MS Homo sapiens
18 CORO6  
Affinity Capture-MS Homo sapiens
19 FAM20B 9917
Affinity Capture-MS Homo sapiens
20 IFITM1 8519
Affinity Capture-MS Homo sapiens
21 PTDSS2 81490
Affinity Capture-MS Homo sapiens
22 MAOB  
Affinity Capture-MS Homo sapiens
23 SLC39A10 57181
Affinity Capture-MS Homo sapiens
24 CUX1 1523
Affinity Capture-MS Homo sapiens
25 YIPF3 25844
Affinity Capture-MS Homo sapiens
26 C10orf35  
Affinity Capture-MS Homo sapiens
27 SCAP  
Affinity Capture-MS Homo sapiens
28 PGRMC2 10424
Affinity Capture-MS Homo sapiens
29 TBC1D15 64786
Affinity Capture-MS Homo sapiens
30 TMOD1  
Affinity Capture-MS Homo sapiens
31 ERMP1 79956
Affinity Capture-MS Homo sapiens
32 NDUFAF1  
Affinity Capture-MS Homo sapiens
33 CCDC115 84317
Affinity Capture-MS Homo sapiens
34 PIGG  
Affinity Capture-MS Homo sapiens
35 SLC25A31 83447
Affinity Capture-MS Homo sapiens
36 LGALS9 3965
Affinity Capture-MS Homo sapiens
37 GPX8 493869
Affinity Capture-MS Homo sapiens
38 KNSTRN  
Affinity Capture-MS Homo sapiens
39 GPRC5C 55890
Affinity Capture-MS Homo sapiens
40 PLCB3 5331
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
41 FADS3 3995
Affinity Capture-MS Homo sapiens
42 TMEM63B 55362
Affinity Capture-MS Homo sapiens
43 KIAA1715 80856
Affinity Capture-MS Homo sapiens
44 PPM1B 5495
Affinity Capture-MS Homo sapiens
45 YIPF6 286451
Affinity Capture-MS Homo sapiens
46 ZDHHC17 23390
Affinity Capture-MS Homo sapiens
47 CNNM4 26504
Affinity Capture-MS Homo sapiens
48 NPC1 4864
Affinity Capture-MS Homo sapiens
49 FUT8 2530
Affinity Capture-MS Homo sapiens
50 TMEM126A 84233
Affinity Capture-MS Homo sapiens
51 MSMO1 6307
Affinity Capture-MS Homo sapiens
52 RAB21 23011
Affinity Capture-MS Homo sapiens
53 KDELR3 11015
Affinity Capture-MS Homo sapiens
54 ATP2A3 489
Affinity Capture-MS Homo sapiens
55 ACP2 53
Affinity Capture-MS Homo sapiens
56 KDSR 2531
Affinity Capture-MS Homo sapiens
57 TTC19  
Affinity Capture-MS Homo sapiens
58 PBXIP1 57326
Affinity Capture-MS Homo sapiens
59 ATP9A 10079
Affinity Capture-MS Homo sapiens
60 SCAMP2 10066
Affinity Capture-MS Homo sapiens
61 HMOX2 3163
Affinity Capture-MS Homo sapiens
62 TNFRSF10C  
Affinity Capture-MS Homo sapiens
63 PREB 10113
Affinity Capture-MS Homo sapiens
64 BCL6  
Affinity Capture-MS Homo sapiens
65 SLC27A1 376497
Affinity Capture-MS Homo sapiens
66 ATP2C1 27032
Affinity Capture-MS Homo sapiens
67 PIGL  
Affinity Capture-MS Homo sapiens
68 ATXN1 6310
Two-hybrid Homo sapiens
69 SEC63 11231
Affinity Capture-MS Homo sapiens
70 TMEM160 54958
Affinity Capture-MS Homo sapiens
71 POTEI 653269
Affinity Capture-MS Homo sapiens
72 SLC39A6 25800
Affinity Capture-MS Homo sapiens
73 TNFSF8  
Affinity Capture-MS Homo sapiens
74 TVP23C  
Affinity Capture-MS Homo sapiens
75 SLC27A4 10999
Affinity Capture-MS Homo sapiens
76 ERGIC3 51614
Affinity Capture-MS Homo sapiens
77 SLC9A3R2 9351
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
78 RMND1 55005
Affinity Capture-MS Homo sapiens
79 FRMD5 84978
Affinity Capture-MS Homo sapiens
80 FDFT1 2222
Affinity Capture-MS Homo sapiens
81 SAAL1 113174
Affinity Capture-MS Homo sapiens
82 RFT1 91869
Affinity Capture-MS Homo sapiens
83 CNIH4  
Affinity Capture-MS Homo sapiens
84 TMCO1 54499
Affinity Capture-MS Homo sapiens
85 ITPRIPL1  
Affinity Capture-MS Homo sapiens
86 SLC30A7 148867
Affinity Capture-MS Homo sapiens
87 CERS6  
Affinity Capture-MS Homo sapiens
88 METTL9 51108
Affinity Capture-MS Homo sapiens
89 YIF1B 90522
Affinity Capture-MS Homo sapiens
90 SLC4A2 6522
Affinity Capture-MS Homo sapiens
91 TPCN1 53373
Affinity Capture-MS Homo sapiens
92 TRIP6 7205
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
93 LRP10 26020
Affinity Capture-MS Homo sapiens
94 HMGCR  
Affinity Capture-MS Homo sapiens
95 ADORA2B  
Affinity Capture-MS Homo sapiens
96 LDLRAD1  
Affinity Capture-MS Homo sapiens
97 GPR180  
Affinity Capture-MS Homo sapiens
98 EMC7 56851
Affinity Capture-MS Homo sapiens
99 LGALS3 3958
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
100 CD47 961
Affinity Capture-MS Homo sapiens
101 TSPAN15 23555
Affinity Capture-MS Homo sapiens
102 B4GAT1 11041
Affinity Capture-MS Homo sapiens
103 AUP1 550
Affinity Capture-MS Homo sapiens
104 ERGIC2 51290
Affinity Capture-MS Homo sapiens
105 TAPBP 6892
Affinity Capture-MS Homo sapiens
106 DAGLB 221955
Affinity Capture-MS Homo sapiens
107 SEC62 7095
Affinity Capture-MS Homo sapiens
108 GOLGA5 9950
Affinity Capture-MS Homo sapiens
109 HSDL1 83693
Affinity Capture-MS Homo sapiens
110 EI24  
Affinity Capture-MS Homo sapiens
111 TAP1 6890
Affinity Capture-MS Homo sapiens
112 THEM6  
Affinity Capture-MS Homo sapiens
113 SPTLC2 9517
Affinity Capture-MS Homo sapiens
114 NOTCH1 4851
Affinity Capture-MS Homo sapiens
115 MGST3 4259
Affinity Capture-MS Homo sapiens
116 ATP13A1 57130
Affinity Capture-MS Homo sapiens
117 ECSIT 51295
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which LPAR2 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here