Gene description for SLC39A4
Gene name solute carrier family 39 (zinc transporter), member 4
Gene symbol SLC39A4
Other names/aliases AEZ
AWMS2
ZIP4
Species Homo sapiens
 Database cross references - SLC39A4
ExoCarta ExoCarta_55630
Vesiclepedia VP_55630
Entrez Gene 55630
HGNC 17129
MIM 607059
UniProt Q6P5W5  
 SLC39A4 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for SLC39A4
Molecular Function
    zinc ion transmembrane transporter activity GO:0005385 IBA
    zinc ion transmembrane transporter activity GO:0005385 IDA
    zinc ion transmembrane transporter activity GO:0005385 TAS
    zinc ion binding GO:0008270 IMP
    identical protein binding GO:0042802 IDA
    metal ion binding GO:0046872 EXP
    zinc ion sensor activity GO:0106219 IMP
    monoatomic cation:bicarbonate symporter activity GO:0140410 IBA
    zinc ion sequestering activity GO:0140486 EXP
    zinc ion sequestering activity GO:0140486 IMP
Biological Process
    intracellular zinc ion homeostasis GO:0006882 ISS
    bicarbonate transport GO:0015701 IEA
    intracellular monoatomic cation homeostasis GO:0030003 IBA
    cellular response to zinc ion starvation GO:0034224 IEA
    zinc ion transmembrane transport GO:0071577 IDA
    zinc ion transmembrane transport GO:0071577 TAS
    zinc ion import across plasma membrane GO:0071578 IBA
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    apical plasma membrane GO:0016324 ISS
    cytoplasmic vesicle GO:0031410 IDA
    recycling endosome membrane GO:0055038 IDA
 Experiment description of studies that identified SLC39A4 in exosomes
1
Experiment ID 211
MISEV standards
EM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
cytochrome c|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
MISEV standards
CEM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
Cytochrome C|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SLC39A4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 KDELR3 11015
Affinity Capture-MS Homo sapiens
2 C5AR1  
Affinity Capture-MS Homo sapiens
3 VTI1B 10490
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 TMEM143  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 VAPA 9218
Affinity Capture-MS Homo sapiens
6 GJA1 2697
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 ATP13A2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 ADRB2  
Two-hybrid Homo sapiens
9 MPZL1 9019
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 S1PR5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 TMEM186  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 GLB1L2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 PTPN1 5770
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 GPR110  
Affinity Capture-MS Homo sapiens
15 FFAR1  
Affinity Capture-MS Homo sapiens
16 LRP10 26020
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 ABCD1 215
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 MGAT5 4249
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 SLC46A1 113235
Affinity Capture-MS Homo sapiens
20 MAOB  
Affinity Capture-MS Homo sapiens
21 UXS1 80146
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 GP1BB 2812
Affinity Capture-MS Homo sapiens
23 TMEM181 57583
Affinity Capture-MS Homo sapiens
24 ELOVL2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 ADCY6 112
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 CUX1 1523
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 MGAT1 4245
Affinity Capture-MS Homo sapiens
28 SLC27A2 11001
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 ABCD3 5825
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 NT5C3A 51251
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 B3GAT3 26229
Affinity Capture-MS Homo sapiens
32 STEAP3 55240
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 SEPN1 57190
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 MRS2  
Affinity Capture-MS Homo sapiens
35 STX6 10228
Affinity Capture-MS Homo sapiens
36 TMEM192 201931
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 ERMP1 79956
Affinity Capture-MS Homo sapiens
38 ORMDL2 29095
Affinity Capture-MS Homo sapiens
39 TMEM201 199953
Affinity Capture-MS Homo sapiens
40 GPX8 493869
Affinity Capture-MS Homo sapiens
41 TMEM106A  
Affinity Capture-MS Homo sapiens
42 FZD7 8324
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 ATP13A3 79572
Affinity Capture-MS Homo sapiens
44 GNPAT 8443
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 AGPAT4 56895
Affinity Capture-MS Homo sapiens
46 GPR17 2840
Affinity Capture-MS Homo sapiens
47 VTI1A 143187
Affinity Capture-MS Homo sapiens
48 TMEM63B 55362
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 KIAA1715 80856
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 GOLIM4 27333
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 TMEM120A 83862
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 EXTL3 2137
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 FAAH  
Affinity Capture-MS Homo sapiens
54 POMGNT1 55624
Affinity Capture-MS Homo sapiens
55 ATP8B2 57198
Affinity Capture-MS Homo sapiens
56 FUT8 2530
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 VPS45 11311
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 TMEM126A 84233
Affinity Capture-MS Homo sapiens
59 P2RY8  
Affinity Capture-MS Homo sapiens
60 C3orf33  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 DUOX1  
Affinity Capture-MS Homo sapiens
62 TMEM43 79188
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 COMTD1 118881
Affinity Capture-MS Homo sapiens
64 UBAC2 337867
Affinity Capture-MS Homo sapiens
65 SREBF2 6721
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 MAN2A2 4122
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 TRIM16 10626
Affinity Capture-MS Homo sapiens
68 ATP9A 10079
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 S1PR1 1901
Affinity Capture-MS Homo sapiens
70 LEMD2 221496
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 CIB1 10519
Affinity Capture-MS Homo sapiens
72 SLC25A17 10478
Affinity Capture-MS Homo sapiens
73 LETMD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 SLC47A1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 ATP2B4 493
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
76 UQCRH 7388
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
77 GPR173  
Affinity Capture-MS Homo sapiens
78 ANKRD13A 88455
Affinity Capture-MS Homo sapiens
79 NDC1 55706
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
80 RER1 11079
Affinity Capture-MS Homo sapiens
81 RMDN3 55177
Affinity Capture-MS Homo sapiens
82 LRRC8A 56262
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
83 MFSD12  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
84 UNC93B1 81622
Affinity Capture-MS Homo sapiens
85 VIPR2  
Affinity Capture-MS Homo sapiens
86 TMEM106B 54664
Affinity Capture-MS Homo sapiens
87 HADHB 3032
Affinity Capture-MS Homo sapiens
88 ZFPL1 7542
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
89 FITM2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
90 SLC27A4 10999
Affinity Capture-MS Homo sapiens
91 P2RY2 5029
Affinity Capture-MS Homo sapiens
92 GPD2 2820
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
93 RMND1 55005
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
94 AAAS 8086
Affinity Capture-MS Homo sapiens
95 OMA1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
96 TMEM246 84302
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
97 GHITM 27069
Affinity Capture-MS Homo sapiens
98 ABHD12 26090
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
99 SLC35B2 347734
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
100 DHRS13  
Affinity Capture-MS Homo sapiens
101 ALG8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
102 YME1L1 10730
Affinity Capture-MS Homo sapiens
103 GPRC5C 55890
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
104 TMCO1 54499
Affinity Capture-MS Homo sapiens
105 GPR45  
Affinity Capture-MS Homo sapiens
106 FAR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
107 SLC25A52  
Affinity Capture-MS Homo sapiens
108 KCNN4 3783
Affinity Capture-MS Homo sapiens
109 ABCB10 23456
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
110 METTL9 51108
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
111 STX10 8677
Affinity Capture-MS Homo sapiens
112 DNAJC15  
Affinity Capture-MS Homo sapiens
113 MAGT1 84061
Affinity Capture-MS Homo sapiens
114 GALNT3 2591
Affinity Capture-MS Homo sapiens
115 SCCPDH 51097
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
116 SLC22A18 5002
Affinity Capture-MS Homo sapiens
117 PIGS 94005
Affinity Capture-MS Homo sapiens
118 SLC27A1 376497
Affinity Capture-MS Homo sapiens
119 SLC4A2 6522
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
120 MBOAT7 79143
Affinity Capture-MS Homo sapiens
121 TMEM87A 25963
Affinity Capture-MS Homo sapiens
122 MANEA 79694
Affinity Capture-MS Homo sapiens
123 PIGW  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
124 MUL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
125 GPR89A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
126 STX16 8675
Affinity Capture-MS Homo sapiens
127 C1orf43 25912
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
128 FZD2 2535
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
129 SIDT2 51092
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
130 L3HYPDH 112849
Affinity Capture-MS Homo sapiens
131 AGPAT9  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
132 PIEZO1 9780
Affinity Capture-MS Homo sapiens
133 PIGO  
Affinity Capture-MS Homo sapiens
134 TMEM120B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
135 FKRP 79147
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
136 EXTL2 2135
Affinity Capture-MS Homo sapiens
137 EFNB1 1947
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
138 PDE3B  
Affinity Capture-MS Homo sapiens
139 PTPN2 5771
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
140 SLITRK5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
141 SFTPC  
Affinity Capture-MS Homo sapiens
142 HACD2 201562
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
143 LPCAT2 54947
Affinity Capture-MS Homo sapiens
144 EDA  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
145 ALG10  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
146 GOLGA5 9950
Affinity Capture-MS Homo sapiens
147 SPPL2B 56928
Affinity Capture-MS Homo sapiens
148 GLT8D1 55830
Affinity Capture-MS Homo sapiens
149 LPAR2 9170
Affinity Capture-MS Homo sapiens
150 SLC1A4 6509
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
151 TPST2 8459
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
152 EI24  
Affinity Capture-MS Homo sapiens
153 CISD2 493856
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
154 APH1A 51107
Affinity Capture-MS Homo sapiens
155 GOLM1 51280
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
156 CKAP4 10970
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
157 CHSY1 22856
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
158 VKORC1L1 154807
Affinity Capture-MS Homo sapiens
159 SCAMP3 10067
Affinity Capture-MS Homo sapiens
160 ELOVL4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
161 MGST3 4259
Affinity Capture-MS Homo sapiens
162 S1PR4  
Affinity Capture-MS Homo sapiens
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