Gene description for SLC39A4
Gene name solute carrier family 39 (zinc transporter), member 4
Gene symbol SLC39A4
Other names/aliases AEZ
AWMS2
ZIP4
Species Homo sapiens
 Database cross references - SLC39A4
ExoCarta ExoCarta_55630
Entrez Gene 55630
HGNC 17129
MIM 607059
UniProt Q6P5W5  
 SLC39A4 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for SLC39A4
Molecular Function
    zinc ion transmembrane transporter activity GO:0005385 IDA
Biological Process
    cellular response to zinc ion starvation GO:0034224 IEA
    zinc II ion transmembrane transport GO:0071577 IEA
    cellular zinc ion homeostasis GO:0006882 IEA
    transmembrane transport GO:0055085 TAS
Subcellular Localization
    apical plasma membrane GO:0016324 IEA
    integral component of membrane GO:0016021 IEA
    plasma membrane GO:0005886 TAS
    cytoplasmic membrane-bounded vesicle GO:0016023 IDA
    extracellular exosome GO:0070062 IDA
    recycling endosome membrane GO:0055038 IEA
 Experiment description of studies that identified SLC39A4 in exosomes
1
Experiment ID 211
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
cytochrome c|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
Cytochrome C|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SLC39A4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SLC39A4 is involved
PathwayEvidenceSource
Zinc influx into cells by the SLC39 gene family TAS Reactome





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