Gene description for METTL9
Gene name methyltransferase like 9
Gene symbol METTL9
Other names/aliases CGI-81
DREV
DREV1
PAP1
Species Homo sapiens
 Database cross references - METTL9
ExoCarta ExoCarta_51108
Vesiclepedia VP_51108
Entrez Gene 51108
HGNC 24586
MIM 609388
UniProt Q9H1A3  
 METTL9 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for METTL9
Molecular Function
    protein binding GO:0005515 IPI
    protein-L-histidine N-pros-methyltransferase activity GO:0106370 IDA
Biological Process
    methylation GO:0032259 IEA
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IDA
    endoplasmic reticulum GO:0005783 IDA
 Experiment description of studies that identified METTL9 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for METTL9
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FUNDC2 65991
Affinity Capture-MS Homo sapiens
2 P2RY2 5029
Affinity Capture-MS Homo sapiens
3 CHRM4  
Two-hybrid Homo sapiens
4 SLC30A2  
Affinity Capture-MS Homo sapiens
5 ZFP36  
Affinity Capture-RNA Homo sapiens
6 CANX 821
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 HLA-DMB 3109
Affinity Capture-MS Homo sapiens
8 BTNL9  
Affinity Capture-MS Homo sapiens
9 ACE 1636
Affinity Capture-MS Homo sapiens
10 SLC39A4 55630
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 SLC30A4 7782
Affinity Capture-MS Homo sapiens
12 LYPD5 284348
Affinity Capture-MS Homo sapiens
13 CLEC2B  
Affinity Capture-MS Homo sapiens
14 KIAA1715 80856
Affinity Capture-MS Homo sapiens
15 HLA-C 3107
Affinity Capture-MS Homo sapiens
16 SLC30A1 7779
Affinity Capture-MS Homo sapiens
17 TMEM120A 83862
Affinity Capture-MS Homo sapiens
18 TMEFF1  
Affinity Capture-MS Homo sapiens
19 CLEC2D  
Affinity Capture-MS Homo sapiens
20 CD70 970
Affinity Capture-MS Homo sapiens
21 DPEP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 SLC30A6 55676
Affinity Capture-MS Homo sapiens
23 TMEM120B  
Affinity Capture-MS Homo sapiens
24 NOMO1 23420
Affinity Capture-MS Homo sapiens
25 TMEM95  
Affinity Capture-MS Homo sapiens
26 ADAM32  
Affinity Capture-MS Homo sapiens
27 TNFRSF9  
Affinity Capture-MS Homo sapiens
28 ST3GAL1 6482
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 WBP1  
Affinity Capture-MS Homo sapiens
30 B3GALT4  
Affinity Capture-MS Homo sapiens
31 AGPAT3 56894
Affinity Capture-MS Homo sapiens
32 FAM174A 345757
Affinity Capture-MS Homo sapiens
33 P2RY8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 IL3RA  
Affinity Capture-MS Homo sapiens
35 FAM20B 9917
Affinity Capture-MS Homo sapiens
36 GCNT2 2651
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 SERINC1 57515
Affinity Capture-MS Homo sapiens
38 FUNDC1  
Affinity Capture-MS Homo sapiens
39 LRRC25  
Affinity Capture-MS Homo sapiens
40 ARMC6 93436
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 C12orf49  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 CHMP6 79643
Two-hybrid Homo sapiens
43 CHRNA9  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 LPCAT2 54947
Affinity Capture-MS Homo sapiens
45 SPN 6693
Affinity Capture-MS Homo sapiens
46 SCARA3  
Affinity Capture-MS Homo sapiens
47 SLC39A10 57181
Affinity Capture-MS Homo sapiens
48 MDN1 23195
Affinity Capture-MS Homo sapiens
49 SLC39A5 283375
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 LPAR2 9170
Affinity Capture-MS Homo sapiens
51 C12orf10 60314
Two-hybrid Homo sapiens
52 NCLN 56926
Affinity Capture-MS Homo sapiens
53 TOR1A 1861
Affinity Capture-MS Homo sapiens
54 LYPD6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 ARL15 54622
Affinity Capture-MS Homo sapiens
56 P2RX2  
Affinity Capture-MS Homo sapiens
57 PITHD1 57095
Affinity Capture-MS Homo sapiens
58 VMA21  
Affinity Capture-MS Homo sapiens
59 GRIN2A  
Affinity Capture-MS Homo sapiens
60 DDX58 23586
Affinity Capture-RNA Homo sapiens
61 STEAP3 55240
Affinity Capture-MS Homo sapiens
62 SLC27A2 11001
Affinity Capture-MS Homo sapiens
63 SLC30A5 64924
Affinity Capture-MS Homo sapiens
64 S1PR4  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which METTL9 is involved
No pathways found





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