Gene description for P2RY2
Gene name purinergic receptor P2Y, G-protein coupled, 2
Gene symbol P2RY2
Other names/aliases HP2U
P2RU1
P2U
P2U1
P2UR
P2Y2
P2Y2R
Species Homo sapiens
 Database cross references - P2RY2
ExoCarta ExoCarta_5029
Vesiclepedia VP_5029
Entrez Gene 5029
HGNC 8541
MIM 600041
UniProt P41231  
 P2RY2 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for P2RY2
Molecular Function
    protein binding GO:0005515 IPI
    A1 adenosine receptor binding GO:0031686 IBA
    signaling receptor activity GO:0038023 TAS
    G protein-coupled purinergic nucleotide receptor activity GO:0045028 IEA
    G protein-coupled UTP receptor activity GO:0045030 IBA
Biological Process
    intracellular monoatomic ion homeostasis GO:0006873 TAS
    G protein-coupled receptor signaling pathway GO:0007186 IBA
    phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200 IEA
    G protein-coupled purinergic nucleotide receptor signaling pathway GO:0035589 IEA
    positive regulation of mucus secretion GO:0070257 IEA
    cellular response to ATP GO:0071318 TAS
    blood vessel diameter maintenance GO:0097746 IEA
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 TAS
 Experiment description of studies that identified P2RY2 in exosomes
1
Experiment ID 211
MISEV standards
EM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
cytochrome c|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
MISEV standards
CEM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
Cytochrome C|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for P2RY2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SLC29A1 2030
Affinity Capture-MS Homo sapiens
2 CMTM6 54918
Affinity Capture-MS Homo sapiens
3 ATPIF1 93974
Affinity Capture-MS Homo sapiens
4 DNAJC11 55735
Affinity Capture-MS Homo sapiens
5 DERL2 51009
Affinity Capture-MS Homo sapiens
6 TMEM161A  
Affinity Capture-MS Homo sapiens
7 DHCR24 1718
Affinity Capture-MS Homo sapiens
8 SACM1L 22908
Affinity Capture-MS Homo sapiens
9 TTYH3 80727
Affinity Capture-MS Homo sapiens
10 SLC39A4 55630
Affinity Capture-MS Homo sapiens
11 KIAA2013 90231
Affinity Capture-MS Homo sapiens
12 ATP12A 479
Affinity Capture-MS Homo sapiens
13 SURF4 6836
Affinity Capture-MS Homo sapiens
14 LMBR1  
Affinity Capture-MS Homo sapiens
15 INTS1 26173
Affinity Capture-MS Homo sapiens
16 SYVN1 84447
Affinity Capture-MS Homo sapiens
17 C1orf112  
Affinity Capture-MS Homo sapiens
18 APP 351
Reconstituted Complex Homo sapiens
19 KDELR1 10945
Affinity Capture-MS Homo sapiens
20 TOMM22 56993
Affinity Capture-MS Homo sapiens
21 APEX1 328
Affinity Capture-RNA Homo sapiens
22 PTDSS2 81490
Affinity Capture-MS Homo sapiens
23 MAOB  
Affinity Capture-MS Homo sapiens
24 MCU 90550
Affinity Capture-MS Homo sapiens
25 RNF5  
Affinity Capture-MS Homo sapiens
26 SLC39A10 57181
Affinity Capture-MS Homo sapiens
27 RINT1 60561
Affinity Capture-MS Homo sapiens
28 FAM8A1 51439
Affinity Capture-MS Homo sapiens
29 TM9SF4 9777
Affinity Capture-MS Homo sapiens
30 SRC 6714
Affinity Capture-Western Homo sapiens
31 INTS12  
Affinity Capture-MS Homo sapiens
32 RER1 11079
Affinity Capture-MS Homo sapiens
33 ATP2A3 489
Affinity Capture-MS Homo sapiens
34 IPO8 10526
Affinity Capture-MS Homo sapiens
35 MRS2  
Affinity Capture-MS Homo sapiens
36 DNAJC16  
Affinity Capture-MS Homo sapiens
37 SLC30A5 64924
Affinity Capture-MS Homo sapiens
38 ERMP1 79956
Affinity Capture-MS Homo sapiens
39 PIGG  
Affinity Capture-MS Homo sapiens
40 ATP13A3 79572
Affinity Capture-MS Homo sapiens
41 TMEM87A 25963
Affinity Capture-MS Homo sapiens
42 ATP1A3 478
Affinity Capture-MS Homo sapiens
43 HEATR1 55127
Affinity Capture-MS Homo sapiens
44 VKORC1L1 154807
Affinity Capture-MS Homo sapiens
45 NOMO1 23420
Affinity Capture-MS Homo sapiens
46 HS2ST1 9653
Affinity Capture-MS Homo sapiens
47 SYNJ2BP 55333
Affinity Capture-MS Homo sapiens
48 ATP9A 10079
Affinity Capture-MS Homo sapiens
49 SCAMP2 10066
Affinity Capture-MS Homo sapiens
50 TMEM259 91304
Affinity Capture-MS Homo sapiens
51 SLC7A6 9057
Affinity Capture-MS Homo sapiens
52 STX5 6811
Affinity Capture-MS Homo sapiens
53 ATP2B4 493
Affinity Capture-MS Homo sapiens
54 SLC4A2 6522
Affinity Capture-MS Homo sapiens
55 CLN3 1201
Affinity Capture-MS Homo sapiens
56 GPAA1 8733
Affinity Capture-MS Homo sapiens
57 FANCD2  
Affinity Capture-MS Homo sapiens
58 ENDOD1 23052
Affinity Capture-MS Homo sapiens
59 YIPF6 286451
Affinity Capture-MS Homo sapiens
60 SLC39A6 25800
Affinity Capture-MS Homo sapiens
61 ATP2B1 490
Affinity Capture-MS Homo sapiens
62 CAV2 858
Affinity Capture-MS Homo sapiens
63 APOB 338
Affinity Capture-MS Homo sapiens
64 SLC30A6 55676
Affinity Capture-MS Homo sapiens
65 ERGIC3 51614
Affinity Capture-MS Homo sapiens
66 DAD1 1603
Affinity Capture-MS Homo sapiens
67 TMEM160 54958
Affinity Capture-MS Homo sapiens
68 RMND1 55005
Affinity Capture-MS Homo sapiens
69 TNPO3 23534
Affinity Capture-MS Homo sapiens
70 TMEM246 84302
Affinity Capture-MS Homo sapiens
71 YIPF5 81555
Affinity Capture-MS Homo sapiens
72 GHITM 27069
Affinity Capture-MS Homo sapiens
73 SGPP1 81537
Affinity Capture-MS Homo sapiens
74 TM9SF3 56889
Affinity Capture-MS Homo sapiens
75 SAAL1 113174
Affinity Capture-MS Homo sapiens
76 XPO4 64328
Affinity Capture-MS Homo sapiens
77 RFT1 91869
Affinity Capture-MS Homo sapiens
78 NLRP3  
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
79 TMCO1 54499
Affinity Capture-MS Homo sapiens
80 ITPRIPL1  
Affinity Capture-MS Homo sapiens
81 SLC30A7 148867
Affinity Capture-MS Homo sapiens
82 METTL9 51108
Affinity Capture-MS Homo sapiens
83 DYM  
Affinity Capture-MS Homo sapiens
84 RNF185  
Affinity Capture-MS Homo sapiens
85 THADA 63892
Affinity Capture-MS Homo sapiens
86 MARCH6  
Affinity Capture-MS Homo sapiens
87 UBE2J1 51465
Affinity Capture-MS Homo sapiens
88 ATP2B3 492
Affinity Capture-MS Homo sapiens
89 TPCN1 53373
Affinity Capture-MS Homo sapiens
90 MBOAT7 79143
Affinity Capture-MS Homo sapiens
91 LBR 3930
Affinity Capture-MS Homo sapiens
92 HMGCR  
Affinity Capture-MS Homo sapiens
93 SLC19A2 10560
Affinity Capture-MS Homo sapiens
94 NUP205 23165
Affinity Capture-MS Homo sapiens
95 GOSR1 9527
Affinity Capture-MS Homo sapiens
96 CLPTM1 1209
Affinity Capture-MS Homo sapiens
97 PIGU 128869
Affinity Capture-MS Homo sapiens
98 SLC39A14 23516
Affinity Capture-MS Homo sapiens
99 RABL3 285282
Affinity Capture-MS Homo sapiens
100 MOV10 4343
Affinity Capture-RNA Homo sapiens
101 GOLGA5 9950
Affinity Capture-MS Homo sapiens
102 ADGRE5 976
Affinity Capture-MS Homo sapiens
103 SCAMP3 10067
Affinity Capture-MS Homo sapiens
104 BRI3BP 140707
Affinity Capture-MS Homo sapiens
105 DERL1 79139
Affinity Capture-MS Homo sapiens
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