Gene description for CAV2
Gene name caveolin 2
Gene symbol CAV2
Other names/aliases CAV
Species Homo sapiens
 Database cross references - CAV2
ExoCarta ExoCarta_858
Vesiclepedia VP_858
Entrez Gene 858
HGNC 1528
MIM 601048
UniProt P51636  
 CAV2 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Hepatocellular carcinoma cells 26054723    
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for CAV2
Molecular Function
    protein binding GO:0005515 IPI
    protein kinase binding GO:0019901 IBA
    protein-macromolecule adaptor activity GO:0030674 IEA
    D1 dopamine receptor binding GO:0031748 IPI
    protein homodimerization activity GO:0042803 IDA
    protein heterodimerization activity GO:0046982 IEA
    molecular adaptor activity GO:0060090 IBA
    scaffold protein binding GO:0097110 IEA
Biological Process
    endothelial cell proliferation GO:0001935 IEA
    negative regulation of endothelial cell proliferation GO:0001937 IBA
    negative regulation of endothelial cell proliferation GO:0001937 ISS
    positive regulation of endothelial cell proliferation GO:0001938 IEA
    vesicle fusion GO:0006906 IDA
    mitochondrion organization GO:0007005 ISS
    endoplasmic reticulum organization GO:0007029 ISS
    regulation of mitotic nuclear division GO:0007088 IEP
    transforming growth factor beta receptor signaling pathway GO:0007179 IEA
    insulin receptor signaling pathway GO:0008286 IBA
    insulin receptor signaling pathway GO:0008286 IDA
    skeletal muscle cell proliferation GO:0014856 IEA
    negative regulation of skeletal muscle cell proliferation GO:0014859 IEA
    vesicle organization GO:0016050 IDA
    receptor-mediated endocytosis of virus by host cell GO:0019065 IGI
    viral release from host cell GO:0019076 IMP
    cell differentiation GO:0030154 IBA
    negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 IEA
    positive regulation of MAPK cascade GO:0043410 IDA
    positive regulation of GTPase activity GO:0043547 IDA
    positive regulation by host of viral process GO:0044794 IMP
    vesicle docking GO:0048278 IDA
    skeletal muscle fiber development GO:0048741 ISS
    regulation of cytosolic calcium ion concentration GO:0051480 IBA
    positive regulation of dopamine receptor signaling pathway GO:0060161 IMP
    caveola assembly GO:0070836 IBA
    caveola assembly GO:0070836 IDA
    caveola assembly GO:0070836 IMP
    basement membrane organization GO:0071711 IEA
Subcellular Localization
    Golgi membrane GO:0000139 IEA
    acrosomal membrane GO:0002080 IEA
    caveolar macromolecular signaling complex GO:0002095 IEA
    nucleus GO:0005634 IEA
    Golgi apparatus GO:0005794 IBA
    Golgi apparatus GO:0005794 ISS
    plasma membrane GO:0005886 IDA
    caveola GO:0005901 IDA
    focal adhesion GO:0005925 IBA
    focal adhesion GO:0005925 IDA
    transport vesicle GO:0030133 IDA
    cytoplasmic vesicle GO:0031410 IBA
    cytoplasmic vesicle GO:0031410 IDA
    protein-containing complex GO:0032991 IDA
    sarcolemma GO:0042383 IBA
    plasma membrane raft GO:0044853 IDA
    membrane raft GO:0045121 IDA
    perinuclear region of cytoplasm GO:0048471 IBA
    perinuclear region of cytoplasm GO:0048471 IDA
 Experiment description of studies that identified CAV2 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
7
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
8
Experiment ID 235
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
RT-PCR
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
9
Experiment ID 236
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
RT-PCR
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
10
Experiment ID 236
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
Western blotting
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for CAV2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
2 RASA1 5921
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
3 ANLN 54443
Affinity Capture-MS Homo sapiens
4 C5AR1  
Affinity Capture-MS Homo sapiens
5 VIPR2  
Affinity Capture-MS Homo sapiens
6 SDCBP 6386
Two-hybrid Homo sapiens
7 GPR141  
Affinity Capture-MS Homo sapiens
8 TACR1  
Affinity Capture-MS Homo sapiens
9 GOLT1A  
Affinity Capture-MS Homo sapiens
10 MOB1B 92597
Affinity Capture-MS Homo sapiens
11 DHCR24 1718
Affinity Capture-MS Homo sapiens
12 NKAIN4  
Affinity Capture-MS Homo sapiens
13 RER1 11079
Affinity Capture-MS Homo sapiens
14 TMEM184A  
Affinity Capture-MS Homo sapiens
15 TAS2R31  
Affinity Capture-MS Homo sapiens
16 P2RY2 5029
Affinity Capture-MS Homo sapiens
17 PTGS1 5742
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
18 CSNK2A1 1457
Biochemical Activity Homo sapiens
19 MFSD8 256471
Affinity Capture-MS Homo sapiens
20 REEP4  
Affinity Capture-MS Homo sapiens
21 AGPAT3 56894
Affinity Capture-MS Homo sapiens
22 PDE2A  
Affinity Capture-MS Homo sapiens
23 SRC 6714
Reconstituted Complex Homo sapiens
24 NCK1 4690
Reconstituted Complex Homo sapiens
25 TMEM43 79188
Affinity Capture-MS Homo sapiens
26 PDE3A  
Affinity Capture-MS Homo sapiens
27 REEP1  
Affinity Capture-MS Homo sapiens
28 SPPL2B 56928
Affinity Capture-MS Homo sapiens
29 TMEM72  
Affinity Capture-MS Homo sapiens
30 EGFR 1956
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
PCA Homo sapiens
Reconstituted Complex Homo sapiens
31 ACKR2  
Affinity Capture-MS Homo sapiens
32 DNAJA1 3301
Two-hybrid Homo sapiens
33 EDNRA 1909
Affinity Capture-MS Homo sapiens
34 VKORC1 79001
Affinity Capture-MS Homo sapiens
35 STBD1 8987
Affinity Capture-MS Homo sapiens
36 YIPF3 25844
Affinity Capture-MS Homo sapiens
37 TMEM147 10430
Affinity Capture-MS Homo sapiens
38 AGPAT2  
Affinity Capture-MS Homo sapiens
39 CAV1 857
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
40 PLD2 5338
Co-fractionation Homo sapiens
41 S1PR4  
Affinity Capture-MS Homo sapiens
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