Gene description for VKORC1
Gene name vitamin K epoxide reductase complex, subunit 1
Gene symbol VKORC1
Other names/aliases EDTP308
IMAGE3455200
MST134
MST576
VKCFD2
VKOR
Species Homo sapiens
 Database cross references - VKORC1
ExoCarta ExoCarta_79001
Vesiclepedia VP_79001
Entrez Gene 79001
HGNC 23663
MIM 608547
UniProt Q9BQB6  
 VKORC1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for VKORC1
Molecular Function
    protein binding GO:0005515 IPI
    vitamin-K-epoxide reductase (warfarin-sensitive) activity GO:0047057 IBA
    vitamin-K-epoxide reductase (warfarin-sensitive) activity GO:0047057 IDA
    vitamin-K-epoxide reductase (warfarin-insensitive) activity GO:0047058 IDA
    quinone binding GO:0048038 IEA
Biological Process
    xenobiotic metabolic process GO:0006805 IMP
    blood coagulation GO:0007596 IBA
    blood coagulation GO:0007596 IMP
    response to organic cyclic compound GO:0014070 IEA
    peptidyl-glutamic acid carboxylation GO:0017187 IMP
    regulation of blood coagulation GO:0030193 IEA
    vitamin K metabolic process GO:0042373 IBA
    vitamin K metabolic process GO:0042373 IDA
    positive regulation of coagulation GO:0050820 IEA
    bone development GO:0060348 ISS
Subcellular Localization
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum membrane GO:0005789 IDA
    endoplasmic reticulum membrane GO:0005789 TAS
 Experiment description of studies that identified VKORC1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for VKORC1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TM4SF5  
Affinity Capture-MS Homo sapiens
2 LIG4 3981
Two-hybrid Homo sapiens
3 Tmed2 56334
Affinity Capture-MS Mus musculus
4 SLC31A2  
Two-hybrid Homo sapiens
5 COMT 1312
Two-hybrid Homo sapiens
6 CPLX4  
Two-hybrid Homo sapiens
7 VAPA 9218
Affinity Capture-MS Homo sapiens
8 ARL6IP5 10550
Two-hybrid Homo sapiens
9 ASGR2  
Two-hybrid Homo sapiens
10 SURF4 6836
Two-hybrid Homo sapiens
11 SLC25A1 6576
Two-hybrid Homo sapiens
12 MSRB1  
Two-hybrid Homo sapiens
13 Ktn1  
Affinity Capture-MS Mus musculus
14 TMEM256 254863
Two-hybrid Homo sapiens
15 APOC1  
Two-hybrid Homo sapiens
16 HP 3240
Two-hybrid Homo sapiens
17 FIS1 51024
Two-hybrid Homo sapiens
18 APOC3 345
Two-hybrid Homo sapiens
19 CXADR 1525
Two-hybrid Homo sapiens
20 AHSG 197
Two-hybrid Homo sapiens
21 Cep85l  
Affinity Capture-MS Mus musculus
22 VKORC1 79001
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
23 MUC1 4582
Two-hybrid Homo sapiens
24 PROCR 10544
Two-hybrid Homo sapiens
25 PIGH  
Two-hybrid Homo sapiens
26 METTL7B  
Two-hybrid Homo sapiens
27 MANBAL 63905
Two-hybrid Homo sapiens
28 TMEM192 201931
Affinity Capture-MS Homo sapiens
29 PDIA6 10130
Two-hybrid Homo sapiens
30 SERPINA1 5265
Two-hybrid Homo sapiens
31 CD81 975
Two-hybrid Homo sapiens
32 RMDN1 51115
Two-hybrid Homo sapiens
33 STAT6 6778
Two-hybrid Homo sapiens
34 TMEM63B 55362
Affinity Capture-MS Homo sapiens
35 PDK1 5163
Affinity Capture-MS Homo sapiens
36 SERP1 27230
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
37 VKORC1L1 154807
Affinity Capture-Western Homo sapiens
38 TREX1  
Two-hybrid Homo sapiens
39 PPIB 5479
Two-hybrid Homo sapiens
40 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
41 CDC23 8697
Affinity Capture-MS Homo sapiens
42 SPTSSA  
Two-hybrid Homo sapiens
43 IFITM3 10410
Two-hybrid Homo sapiens
44 TRAM1 23471
Two-hybrid Homo sapiens
45 JAGN1 84522
Two-hybrid Homo sapiens
46 GORAB 92344
Two-hybrid Homo sapiens
47 APLP2 334
Two-hybrid Homo sapiens
48 Pabpc1 18458
Affinity Capture-MS Mus musculus
49 YIF1A 10897
Two-hybrid Homo sapiens
50 APOA2 336
Two-hybrid Homo sapiens
51 CAV2 858
Affinity Capture-MS Homo sapiens
52 TMEM45B 120224
Two-hybrid Homo sapiens
53 CREB3  
Two-hybrid Homo sapiens
54 GJB1 2705
Two-hybrid Homo sapiens
55 PPA2 27068
Two-hybrid Homo sapiens
56 SNORA12  
Two-hybrid Homo sapiens
57 SLC15A3  
Two-hybrid Homo sapiens
58 CD63 967
Two-hybrid Homo sapiens
59 FGG 2266
Two-hybrid Homo sapiens
60 SAT1  
Two-hybrid Homo sapiens
61 RMND5A 64795
Two-hybrid Homo sapiens
62 RMDN3 55177
Two-hybrid Homo sapiens
63 CLDN10  
Two-hybrid Homo sapiens
64 CCDC12  
Two-hybrid Homo sapiens
65 REEP5 7905
Two-hybrid Homo sapiens
66 CNN3 1266
Two-hybrid Homo sapiens
67 VAPB 9217
Two-hybrid Homo sapiens
68 HSD17B7 51478
Two-hybrid Homo sapiens
69 PCDH1 5097
Two-hybrid Homo sapiens
70 TMPRSS11B 132724
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 MSMO1 6307
Two-hybrid Homo sapiens
72 TMEM134  
Two-hybrid Homo sapiens
73 GOLT1B 51026
Affinity Capture-MS Homo sapiens
74 BCAP31 10134
Two-hybrid Homo sapiens
75 ATP6AP2 10159
Two-hybrid Homo sapiens
76 NR3C1 2908
Proximity Label-MS Homo sapiens
77 CD9 928
Two-hybrid Homo sapiens
78 CREB3L1  
Two-hybrid Homo sapiens
79 TMEM242  
Two-hybrid Homo sapiens
80 C1S 716
Two-hybrid Homo sapiens
81 FAM209A 200232
Two-hybrid Homo sapiens
82 HOMER2  
Two-hybrid Homo sapiens
83 TMEM176A  
Two-hybrid Homo sapiens
84 CNR2  
Affinity Capture-MS Homo sapiens
85 SCGB2A2  
Affinity Capture-MS Homo sapiens
86 PSCA 8000
Affinity Capture-MS Homo sapiens
87 DPM2 8818
Two-hybrid Homo sapiens
88 PLP2 5355
Two-hybrid Homo sapiens
89 ILK 3611
Affinity Capture-MS Homo sapiens
90 ZMYM6NB  
Two-hybrid Homo sapiens
91 FGL1  
Two-hybrid Homo sapiens
92 FTL 2512
Two-hybrid Homo sapiens
93 TMEM230 29058
Two-hybrid Homo sapiens
94 CCDC167  
Two-hybrid Homo sapiens
95 ASGR1 432
Two-hybrid Homo sapiens
96 PCMT1 5110
Two-hybrid Homo sapiens
97 HDAC6 10013
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
98 SAA1 6288
Two-hybrid Homo sapiens
99 ATP5G3 518
Two-hybrid Homo sapiens
100 GPR152  
Two-hybrid Homo sapiens
101 MT1X 4501
Two-hybrid Homo sapiens
102 EBP  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
103 APOC4  
Two-hybrid Homo sapiens
104 OS9 10956
Affinity Capture-MS Homo sapiens
105 HPR 3250
Two-hybrid Homo sapiens
106 ECHDC1 55862
Two-hybrid Homo sapiens
107 TF 7018
Two-hybrid Homo sapiens
108 TMEM120A 83862
Two-hybrid Homo sapiens
109 Kcnk1  
Affinity Capture-MS Mus musculus
110 KCNK17  
Two-hybrid Homo sapiens
111 ZCCHC24 219654
Two-hybrid Homo sapiens
112 SERBP1 26135
Affinity Capture-MS Homo sapiens
113 TMBIM4  
Two-hybrid Homo sapiens
114 Smn1 20595
Affinity Capture-MS Mus musculus
115 HAMP  
Two-hybrid Homo sapiens
116 FAM210B  
Two-hybrid Homo sapiens
117 APOA1 335
Two-hybrid Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here