Gene description for MANBAL
Gene name mannosidase, beta A, lysosomal-like
Gene symbol MANBAL
Other names/aliases -
Species Homo sapiens
 Database cross references - MANBAL
ExoCarta ExoCarta_63905
Vesiclepedia VP_63905
Entrez Gene 63905
HGNC 15799
UniProt Q9NQG1  
 MANBAL identified in exosomes derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for MANBAL
Molecular Function
    protein binding GO:0005515 IPI
Subcellular Localization
    membrane GO:0016020 IEA
 Experiment description of studies that identified MANBAL in exosomes
1
Experiment ID 834
MISEV standards
EM
Biophysical techniques
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
EM
Biophysical techniques
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for MANBAL
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 LYRM2  
Affinity Capture-MS Homo sapiens
2 OTOP2  
Two-hybrid Homo sapiens
3 GPR151  
Two-hybrid Homo sapiens
4 CACNA1A  
Two-hybrid Homo sapiens
5 TMBIM6 7009
Two-hybrid Homo sapiens
6 VTI1B 10490
Two-hybrid Homo sapiens
7 CANX 821
Affinity Capture-MS Homo sapiens
8 KLK5 25818
Two-hybrid Homo sapiens
9 S100A6 6277
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 TMEM203  
Two-hybrid Homo sapiens
11 NR3C1 2908
Proximity Label-MS Homo sapiens
12 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
13 CMTM2  
Two-hybrid Homo sapiens
14 SCRG1  
Two-hybrid Homo sapiens
15 STX3 6809
Two-hybrid Homo sapiens
16 TMEM262  
Two-hybrid Homo sapiens
17 VKORC1 79001
Two-hybrid Homo sapiens
18 GOPC 57120
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 MPDU1 9526
Two-hybrid Homo sapiens
20 PIGF  
Two-hybrid Homo sapiens
21 MARCH5  
Two-hybrid Homo sapiens
22 UBQLN1 29979
Two-hybrid Homo sapiens
23 TMEM115 11070
Two-hybrid Homo sapiens
24 MALL  
Two-hybrid Homo sapiens
25 ATP13A1 57130
Two-hybrid Homo sapiens
26 CCDC47 57003
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which MANBAL is involved
No pathways found





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