Gene description for KLK5
Gene name kallikrein-related peptidase 5
Gene symbol KLK5
Other names/aliases KLK-L2
KLKL2
SCTE
Species Homo sapiens
 Database cross references - KLK5
ExoCarta ExoCarta_25818
Entrez Gene 25818
HGNC 6366
MIM 605643
UniProt Q9Y337  
 KLK5 identified in exosomes derived from the following tissue/cell type
Keratinocytes 19530224    
Keratinocytes 19530224    
 Gene ontology annotations for KLK5
Molecular Function
    protein binding GO:0005515 IPI
    serine-type peptidase activity GO:0008236 TAS
    peptidase activity GO:0008233 TAS
    serine-type endopeptidase activity GO:0004252 NAS
Biological Process
    proteolysis GO:0006508 IEA
    positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 IDA
    epidermis development GO:0008544 TAS
Subcellular Localization
    extracellular space GO:0005615 TAS
    epidermal lamellar body GO:0097209 IDA
 Experiment description of studies that identified KLK5 in exosomes
1
Experiment ID 189
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19530224    
Organism Homo sapiens
Experiment description Profile of exosomes related proteins released by differentiated and undifferentiated human keratinocytes.
Authors Chavez-Muñoz C, Kilani RT, Ghahary A.
Journal name J Cell Physiol
Publication year 2009
Sample Keratinocytes
Sample name Keratinocytes - Differentiated
Isolation/purification methods Differential centrifugation
Filtration
Sucrose cushion
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 190
ISEV standards
EM
EV Biophysical techniques
HSC70
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19530224    
Organism Homo sapiens
Experiment description Profile of exosomes related proteins released by differentiated and undifferentiated human keratinocytes.
Authors Chavez-Muñoz C, Kilani RT, Ghahary A.
Journal name J Cell Physiol
Publication year 2009
Sample Keratinocytes
Sample name Keratinocytes - Undifferentiated
Isolation/purification methods Differential centrifugation
Filtration
Sucrose cushion
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for KLK5
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which KLK5 is involved
No pathways found





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