Gene description for KLK5
Gene name kallikrein-related peptidase 5
Gene symbol KLK5
Other names/aliases KLK-L2
KLKL2
SCTE
Species Homo sapiens
 Database cross references - KLK5
ExoCarta ExoCarta_25818
Vesiclepedia VP_25818
Entrez Gene 25818
HGNC 6366
MIM 605643
UniProt Q9Y337  
 KLK5 identified in exosomes derived from the following tissue/cell type
Keratinocytes 19530224    
Keratinocytes 19530224    
 Gene ontology annotations for KLK5
Molecular Function
    serine-type endopeptidase activity GO:0004252 EXP
    serine-type endopeptidase activity GO:0004252 IBA
    serine-type endopeptidase activity GO:0004252 IDA
    serine-type endopeptidase activity GO:0004252 NAS
    protein binding GO:0005515 IPI
    peptidase activity GO:0008233 IMP
    serine-type peptidase activity GO:0008236 TAS
Biological Process
    positive regulation of antibacterial peptide production GO:0002803 IMP
    proteolysis GO:0006508 IEA
    epidermis development GO:0008544 TAS
    extracellular matrix disassembly GO:0022617 IBA
    positive regulation of G protein-coupled receptor signaling pathway GO:0045745 IDA
    protein maturation GO:0051604 IBA
    cornification GO:0070268 TAS
    amelogenesis GO:0097186 IBA
Subcellular Localization
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 IBA
    extracellular space GO:0005615 IMP
    cytosol GO:0005829 TAS
    secretory granule GO:0030141 IBA
    epidermal lamellar body GO:0097209 IDA
 Experiment description of studies that identified KLK5 in exosomes
1
Experiment ID 189
MISEV standards
EM
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19530224    
Organism Homo sapiens
Experiment description Profile of exosomes related proteins released by differentiated and undifferentiated human keratinocytes.
Authors "Chavez-Muñoz C, Kilani RT, Ghahary A."
Journal name J Cell Physiol
Publication year 2009
Sample Keratinocytes
Sample name Keratinocytes - Differentiated
Isolation/purification methods Differential centrifugation
Filtration
Sucrose cushion
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 190
MISEV standards
EM
Biophysical techniques
HSC70
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19530224    
Organism Homo sapiens
Experiment description Profile of exosomes related proteins released by differentiated and undifferentiated human keratinocytes.
Authors "Chavez-Muñoz C, Kilani RT, Ghahary A."
Journal name J Cell Physiol
Publication year 2009
Sample Keratinocytes
Sample name Keratinocytes - Undifferentiated
Isolation/purification methods Differential centrifugation
Filtration
Sucrose cushion
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for KLK5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PEX6  
Affinity Capture-MS Homo sapiens
2 PRPS1L1 221823
Affinity Capture-MS Homo sapiens
3 MCM8 84515
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 TUBB3 10381
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 ARSA 410
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 BBS7 55212
Affinity Capture-MS Homo sapiens
7 TUBB8 347688
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 EME1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 FUK 197258
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 CBWD2  
Affinity Capture-MS Homo sapiens
11 TRAPPC9 83696
Affinity Capture-MS Homo sapiens
12 PI4KA 5297
Affinity Capture-MS Homo sapiens
13 LRP6 4040
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 LRP5 4041
Affinity Capture-MS Homo sapiens
15 TRMT44  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 TM9SF4 9777
Affinity Capture-MS Homo sapiens
17 SEL1L 6400
Affinity Capture-MS Homo sapiens
18 TMLHE 55217
Affinity Capture-MS Homo sapiens
19 OAF 220323
Affinity Capture-MS Homo sapiens
20 MANBAL 63905
Two-hybrid Homo sapiens
21 RHOT1 55288
Affinity Capture-MS Homo sapiens
22 ATP1A3 478
Affinity Capture-MS Homo sapiens
23 METTL13 51603
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 DDX19B 11269
Affinity Capture-MS Homo sapiens
25 KIAA1147  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 GGT7 2686
Affinity Capture-MS Homo sapiens
27 ZDHHC19  
Affinity Capture-MS Homo sapiens
28 TUBA1A 7846
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 TUFM 7284
Affinity Capture-MS Homo sapiens
30 TUBA1C 84790
Affinity Capture-MS Homo sapiens
31 ND1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 FRAS1 80144
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 ALDH3A1 218
Affinity Capture-MS Homo sapiens
34 NARS2  
Affinity Capture-MS Homo sapiens
35 RHOT2 89941
Affinity Capture-MS Homo sapiens
36 TMED1 11018
Affinity Capture-MS Homo sapiens
37 CERCAM 51148
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 TXNDC11 51061
Affinity Capture-MS Homo sapiens
39 AP3S1 1176
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 NEU3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 HSPA5 3309
Affinity Capture-MS Homo sapiens
42 SLC25A25  
Affinity Capture-MS Homo sapiens
43 TUBB 203068
Affinity Capture-MS Homo sapiens
44 LOXL2 4017
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 POLE2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 BMP8B  
Affinity Capture-MS Homo sapiens
47 TXNRD3  
Affinity Capture-MS Homo sapiens
48 PON2 5445
Affinity Capture-MS Homo sapiens
49 CDC42EP1 11135
Affinity Capture-MS Homo sapiens
50 ERLEC1 27248
Affinity Capture-MS Homo sapiens
51 ACAD10  
Affinity Capture-MS Homo sapiens
52 TUBB4B 10383
Affinity Capture-MS Homo sapiens
53 FTH1 2495
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 C21orf59 56683
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 CECR5 27440
Affinity Capture-MS Homo sapiens
56 PCDH7 5099
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 MAP2K3 5606
Affinity Capture-MS Homo sapiens
58 FUT11 170384
Affinity Capture-MS Homo sapiens
59 PI4KAP1  
Affinity Capture-MS Homo sapiens
60 LDLR 3949
Affinity Capture-MS Homo sapiens
61 FBXO2 26232
Affinity Capture-MS Homo sapiens
62 DHRS7B 25979
Affinity Capture-MS Homo sapiens
63 PRSS8 5652
Affinity Capture-MS Homo sapiens
64 CBWD1 55871
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 SARDH 1757
Affinity Capture-MS Homo sapiens
66 PASK  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 NUBPL 80224
Affinity Capture-MS Homo sapiens
68 NAT2 10
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 PRSS16 10279
Affinity Capture-MS Homo sapiens
70 TUBB2A 7280
Affinity Capture-MS Homo sapiens
71 TIMP1 7076
Affinity Capture-MS Homo sapiens
72 TTC5  
Affinity Capture-MS Homo sapiens
73 RHOBTB3 22836
Affinity Capture-MS Homo sapiens
74 L3HYPDH 112849
Affinity Capture-MS Homo sapiens
75 MKS1 54903
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
76 TTC27 55622
Affinity Capture-MS Homo sapiens
77 SLCO4A1 28231
Affinity Capture-MS Homo sapiens
78 VWA9  
Affinity Capture-MS Homo sapiens
79 FREM2 341640
Affinity Capture-MS Homo sapiens
80 TUBA4A 7277
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
81 GPR107 57720
Affinity Capture-MS Homo sapiens
82 CHD1L 9557
Affinity Capture-MS Homo sapiens
83 OS9 10956
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
84 CPNE1 8904
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
85 TUBB4A 10382
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
86 TUBB6 84617
Affinity Capture-MS Homo sapiens
87 PC 5091
Affinity Capture-MS Homo sapiens
88 CELSR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
89 TEFM  
Affinity Capture-MS Homo sapiens
90 CLSTN3 9746
Affinity Capture-MS Homo sapiens
91 CBWD3  
Affinity Capture-MS Homo sapiens
92 PTPRK 5796
Affinity Capture-MS Homo sapiens
93 MOCS3 27304
Affinity Capture-MS Homo sapiens
94 ITGB5 3693
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
95 CLP1  
Affinity Capture-MS Homo sapiens
96 COX11  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
97 CCND3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
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