Gene description for FUK
Gene name fucokinase
Gene symbol FUK
Other names/aliases 1110046B12Rik
Species Homo sapiens
 Database cross references - FUK
ExoCarta ExoCarta_197258
Vesiclepedia VP_197258
Entrez Gene 197258
HGNC 29500
MIM 608675
UniProt Q8N0W3  
 FUK identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells 34887515    
Thymus 23844026    
 Gene ontology annotations for FUK
Molecular Function
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    fucokinase activity GO:0050201 IBA
    fucokinase activity GO:0050201 IMP
    fucokinase activity GO:0050201 NAS
    fucokinase activity GO:0050201 TAS
Biological Process
    GDP-L-fucose biosynthetic process GO:0042350 TAS
    GDP-L-fucose salvage GO:0042352 IBA
    GDP-L-fucose salvage GO:0042352 IMP
    carbohydrate phosphorylation GO:0046835 IEA
    response to dopamine GO:1903350 IEA
Subcellular Localization
    cytosol GO:0005829 TAS
 Experiment description of studies that identified FUK in exosomes
1
Experiment ID 1203
MISEV standards
EM
Biophysical techniques
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
2
Experiment ID 217
MISEV standards
EM
Biophysical techniques
TSG101|CD81|CD9|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for FUK
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PRKCSH 5589
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 NPAS1  
Affinity Capture-MS Homo sapiens
3 RNF123 63891
Affinity Capture-MS Homo sapiens
4 FBXW5  
Affinity Capture-MS Homo sapiens
5 VAPB 9217
Affinity Capture-MS Homo sapiens
6 CUL3 8452
Affinity Capture-MS Homo sapiens
7 DHCR24 1718
Affinity Capture-MS Homo sapiens
8 KLK5 25818
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 HSPA8 3312
Affinity Capture-MS Homo sapiens
10 HCST  
Affinity Capture-MS Homo sapiens
11 MFSD4  
Affinity Capture-MS Homo sapiens
12 POGZ 23126
Two-hybrid Homo sapiens
13 NPTN 27020
Affinity Capture-MS Homo sapiens
14 TRIM66  
Affinity Capture-MS Homo sapiens
15 FAM96A  
Affinity Capture-MS Homo sapiens
16 HDHD1  
Affinity Capture-MS Homo sapiens
17 HSPA1L 3305
Affinity Capture-MS Homo sapiens
18 PRMT6  
Affinity Capture-MS Homo sapiens
19 FPR1  
Affinity Capture-MS Homo sapiens
20 TLX3  
Two-hybrid Homo sapiens
21 B4GALT2  
Affinity Capture-MS Homo sapiens
22 GZMH  
Affinity Capture-MS Homo sapiens
23 C12orf74  
Affinity Capture-MS Homo sapiens
24 INF2 64423
Affinity Capture-MS Homo sapiens
25 LRRC29  
Affinity Capture-MS Homo sapiens
26 LOC554223  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 GPR45  
Affinity Capture-MS Homo sapiens
28 D2HGDH 728294
Affinity Capture-MS Homo sapiens
29 GPR182  
Affinity Capture-MS Homo sapiens
30 FIGF 2277
Affinity Capture-MS Homo sapiens
31 COQ3  
Affinity Capture-MS Homo sapiens
32 NUP210P1  
Affinity Capture-MS Homo sapiens
33 SF3B3 23450
Affinity Capture-MS Homo sapiens
34 TRMU  
Affinity Capture-MS Homo sapiens
35 HSPA1B 3304
Affinity Capture-MS Homo sapiens
36 CUL4A 8451
Affinity Capture-MS Homo sapiens
37 UBXN6 80700
Affinity Capture-MS Homo sapiens
38 UPP1 7378
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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