Gene description for FIGF
Gene name c-fos induced growth factor (vascular endothelial growth factor D)
Gene symbol FIGF
Other names/aliases VEGF-D
VEGFD
Species Homo sapiens
 Database cross references - FIGF
ExoCarta ExoCarta_2277
Vesiclepedia VP_2277
Entrez Gene 2277
HGNC 3708
MIM 300091
UniProt O43915  
 FIGF identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for FIGF
Molecular Function
    platelet-derived growth factor receptor binding GO:0005161 TAS
    vascular endothelial growth factor receptor binding GO:0005172 IBA
    vascular endothelial growth factor receptor binding GO:0005172 IPI
    protein binding GO:0005515 IPI
    growth factor activity GO:0008083 IBA
    chemoattractant activity GO:0042056 IBA
    chemoattractant activity GO:0042056 IDA
    identical protein binding GO:0042802 IEA
    vascular endothelial growth factor receptor 3 binding GO:0043185 IEA
Biological Process
    response to hypoxia GO:0001666 IBA
    sprouting angiogenesis GO:0002040 IBA
    positive regulation of cell population proliferation GO:0008284 IEA
    response to bacterium GO:0009617 IEA
    vascular endothelial growth factor signaling pathway GO:0038084 IBA
    vascular endothelial growth factor receptor signaling pathway GO:0048010 IBA
    fibroblast proliferation GO:0048144 IEA
    positive chemotaxis GO:0050918 IEA
    induction of positive chemotaxis GO:0050930 IBA
    induction of positive chemotaxis GO:0050930 IDA
    positive regulation of cell division GO:0051781 IEA
    positive regulation of mast cell chemotaxis GO:0060754 IBA
    positive regulation of mast cell chemotaxis GO:0060754 IDA
    dopaminergic neuron differentiation GO:0071542 IEA
Subcellular Localization
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 IBA
    membrane GO:0016020 IEA
    platelet alpha granule lumen GO:0031093 TAS
 Experiment description of studies that identified FIGF in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for FIGF
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 F10 2159
Affinity Capture-MS Homo sapiens
2 ADAMTS7  
Affinity Capture-MS Homo sapiens
3 RPSAP58 388524
Affinity Capture-MS Homo sapiens
4 MR1  
Affinity Capture-MS Homo sapiens
5 SORL1 6653
Affinity Capture-MS Homo sapiens
6 TOR1B 27348
Affinity Capture-MS Homo sapiens
7 FLT4  
Reconstituted Complex Homo sapiens
8 UBR4 23352
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 MBTPS1 8720
Affinity Capture-MS Homo sapiens
10 KCMF1 56888
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 TUBB8 347688
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 PROS1 5627
Affinity Capture-MS Homo sapiens
13 FUK 197258
Affinity Capture-MS Homo sapiens
14 TUBB3 10381
Affinity Capture-MS Homo sapiens
15 SIL1 64374
Affinity Capture-MS Homo sapiens
16 CBWD2  
Affinity Capture-MS Homo sapiens
17 BIRC6 57448
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 FRAS1 80144
Affinity Capture-MS Homo sapiens
19 Kdr  
Reconstituted Complex Mus musculus
20 VWDE  
Affinity Capture-MS Homo sapiens
21 CHRNA5  
Affinity Capture-MS Homo sapiens
22 PBXIP1 57326
Affinity Capture-MS Homo sapiens
23 HLA-F 3134
Affinity Capture-MS Homo sapiens
24 ADAM9 8754
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 CBWD3  
Affinity Capture-MS Homo sapiens
26 ZBTB25  
Affinity Capture-Luminescence Homo sapiens
27 ZER1 10444
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 RCN2 5955
Affinity Capture-MS Homo sapiens
29 OAF 220323
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 MOCS3 27304
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 PTPRU  
Affinity Capture-MS Homo sapiens
32 KDR  
Reconstituted Complex Homo sapiens
33 CBWD1 55871
Affinity Capture-MS Homo sapiens
34 NOTCH1 4851
Affinity Capture-MS Homo sapiens
35 MFGE8 4240
Affinity Capture-MS Homo sapiens
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