Gene description for SORL1
Gene name sortilin-related receptor, L(DLR class) A repeats containing
Gene symbol SORL1
Other names/aliases C11orf32
LR11
LRP9
SORLA
SorLA-1
gp250
Species Homo sapiens
 Database cross references - SORL1
ExoCarta ExoCarta_6653
Vesiclepedia VP_6653
Entrez Gene 6653
HGNC 11185
MIM 602005
UniProt Q92673  
 SORL1 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
Urine 19056867    
 Gene ontology annotations for SORL1
Molecular Function
    amyloid-beta binding GO:0001540 IDA
    amyloid-beta binding GO:0001540 IPI
    transmembrane signaling receptor activity GO:0004888 IDA
    low-density lipoprotein particle receptor activity GO:0005041 TAS
    protein binding GO:0005515 IPI
    aspartic-type endopeptidase inhibitor activity GO:0019828 IDA
    aspartic-type endopeptidase inhibitor activity GO:0019828 IMP
    low-density lipoprotein particle binding GO:0030169 IPI
    small GTPase binding GO:0031267 IPI
    neuropeptide binding GO:0042923 IPI
Biological Process
    diet induced thermogenesis GO:0002024 ISS
    protein targeting GO:0006605 IDA
    protein targeting GO:0006605 IMP
    protein targeting to lysosome GO:0006622 IBA
    protein targeting to lysosome GO:0006622 IDA
    post-Golgi vesicle-mediated transport GO:0006892 IBA
    post-Golgi vesicle-mediated transport GO:0006892 IDA
    receptor-mediated endocytosis GO:0006898 IDA
    neuropeptide signaling pathway GO:0007218 IDA
    negative regulation of triglyceride catabolic process GO:0010897 ISS
    regulation of smooth muscle cell migration GO:0014910 IDA
    cell migration GO:0016477 IEA
    negative regulation of BMP signaling pathway GO:0030514 ISS
    negative regulation of protein-containing complex assembly GO:0031333 IMP
    protein localization to Golgi apparatus GO:0034067 IDA
    insulin receptor recycling GO:0038020 IDA
    protein retention in Golgi apparatus GO:0045053 IBA
    protein retention in Golgi apparatus GO:0045053 IDA
    positive regulation of protein catabolic process GO:0045732 IDA
    positive regulation of insulin receptor signaling pathway GO:0046628 IDA
    negative regulation of neurogenesis GO:0050768 ISS
    protein maturation GO:0051604 IDA
    positive regulation of protein exit from endoplasmic reticulum GO:0070863 IMP
    endosome to plasma membrane protein transport GO:0099638 IEA
    positive regulation of glial cell-derived neurotrophic factor production GO:1900168 IDA
    negative regulation of amyloid-beta formation GO:1902430 IDA
    negative regulation of amyloid-beta formation GO:1902430 IMP
    positive regulation of ER to Golgi vesicle-mediated transport GO:1902953 IMP
    positive regulation of early endosome to recycling endosome transport GO:1902955 IMP
    positive regulation of protein localization to early endosome GO:1902966 IMP
    negative regulation of amyloid precursor protein catabolic process GO:1902992 IDA
    negative regulation of amyloid precursor protein catabolic process GO:1902992 IMP
    negative regulation of neurofibrillary tangle assembly GO:1902997 ISS
    positive regulation of adipose tissue development GO:1904179 IDA
    adaptive thermogenesis GO:1990845 ISS
    positive regulation of endocytic recycling GO:2001137 IMP
Subcellular Localization
    Golgi membrane GO:0000139 TAS
    extracellular space GO:0005615 IDA
    nuclear envelope lumen GO:0005641 IDA
    endosome GO:0005768 IDA
    early endosome GO:0005769 IDA
    early endosome GO:0005769 IMP
    multivesicular body GO:0005771 IDA
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum membrane GO:0005789 IEA
    Golgi apparatus GO:0005794 IBA
    Golgi apparatus GO:0005794 IDA
    trans-Golgi network GO:0005802 IDA
    plasma membrane GO:0005886 IDA
    cell surface GO:0009986 IDA
    endosome membrane GO:0010008 TAS
    membrane GO:0016020 IBA
    membrane GO:0016020 IDA
    transport vesicle membrane GO:0030658 IEA
    early endosome membrane GO:0031901 IEA
    Golgi cisterna GO:0031985 IDA
    multivesicular body membrane GO:0032585 IEA
    neuronal cell body GO:0043025 IEA
    recycling endosome GO:0055037 IMP
    recycling endosome membrane GO:0055038 IEA
    extracellular exosome GO:0070062 HDA
    perinucleolar compartment GO:0097356 IEA
 Experiment description of studies that identified SORL1 in exosomes
1
Experiment ID 207
MISEV standards
EM
Biophysical techniques
TSG101|HSP70|FLOT1
Enriched markers
VDAC
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DKO-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 208
MISEV standards
EM
Biophysical techniques
TSG101|HSP70|FLOT1
Enriched markers
VDAC
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name Dks-8
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 209
MISEV standards
Biophysical techniques
TSG101|HSP70|FLOT1
Enriched markers
VDAC
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DLD-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 211
MISEV standards
EM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
cytochrome c|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
5
Experiment ID 212
MISEV standards
CEM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
Cytochrome C|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
6
Experiment ID 834
MISEV standards
EM
Biophysical techniques
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
7
Experiment ID 835
MISEV standards
EM
Biophysical techniques
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
8
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for SORL1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SORL1 6653
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
2 ZNF34  
Affinity Capture-MS Homo sapiens
3 RPL10 6134
Affinity Capture-MS Homo sapiens
4 LGALS1 3956
Affinity Capture-MS Homo sapiens
5 ZNF354C  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 SLURP1  
Affinity Capture-MS Homo sapiens
7 ZNF224  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 ZNF584  
Affinity Capture-MS Homo sapiens
9 CEP97 79598
Affinity Capture-MS Homo sapiens
10 RSPO1  
Affinity Capture-MS Homo sapiens
11 ZNF408  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 ZNF74  
Affinity Capture-MS Homo sapiens
13 COPS6 10980
Affinity Capture-MS Homo sapiens
14 ZNF485  
Affinity Capture-MS Homo sapiens
15 BRWD3  
Affinity Capture-MS Homo sapiens
16 PACS1 55690
Affinity Capture-Western Homo sapiens
17 COPS5 10987
Affinity Capture-MS Homo sapiens
18 CLEC2B  
Affinity Capture-MS Homo sapiens
19 ZSCAN21  
Affinity Capture-MS Homo sapiens
20 SOST  
Affinity Capture-MS Homo sapiens
21 GGA1 26088
Protein-peptide Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
22 FOXD4L6  
Affinity Capture-MS Homo sapiens
23 IGFL3  
Affinity Capture-MS Homo sapiens
24 ICAM4  
Affinity Capture-MS Homo sapiens
25 LGALS9 3965
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 CUL1 8454
Affinity Capture-MS Homo sapiens
27 BTNL2  
Affinity Capture-MS Homo sapiens
28 ERBB2 2064
Co-localization Homo sapiens
Reconstituted Complex Homo sapiens
29 RHOH  
Two-hybrid Homo sapiens
30 TAZ  
Affinity Capture-MS Homo sapiens
31 GGA2 23062
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
32 AURKA 6790
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 PPP1CA 5499
Two-hybrid Homo sapiens
34 DLD 1738
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 FAM19A4  
Affinity Capture-MS Homo sapiens
36 CUL3 8452
Affinity Capture-MS Homo sapiens
37 FOXI2  
Affinity Capture-MS Homo sapiens
38 ERBB3 2065
Co-localization Homo sapiens
Reconstituted Complex Homo sapiens
39 GDF15 9518
Affinity Capture-MS Homo sapiens
40 GOLGA8G  
Affinity Capture-MS Homo sapiens
41 FAM19A3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 POU6F2  
Two-hybrid Homo sapiens
43 ZFP41  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 SDF2L1 23753
Affinity Capture-MS Homo sapiens
45 SIRPD  
Affinity Capture-MS Homo sapiens
46 FIGF 2277
Affinity Capture-MS Homo sapiens
47 Arhgef2  
Affinity Capture-MS Mus musculus
48 FEZF1  
Affinity Capture-MS Homo sapiens
49 PATE1  
Affinity Capture-MS Homo sapiens
50 FAM19A2 338811
Affinity Capture-MS Homo sapiens
51 SP110  
Affinity Capture-MS Homo sapiens
52 CFC1  
Affinity Capture-MS Homo sapiens
53 DKK2  
Affinity Capture-MS Homo sapiens
54 APOE 348
Reconstituted Complex Homo sapiens
55 FAM76B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 ZBBX  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 ABT1 29777
Affinity Capture-MS Homo sapiens
58 CANX 821
Affinity Capture-MS Homo sapiens
59 SORT1 6272
Reconstituted Complex Homo sapiens
60 POP1 10940
Affinity Capture-MS Homo sapiens
61 RLN1  
Affinity Capture-MS Homo sapiens
62 CMA1  
Affinity Capture-MS Homo sapiens
63 SREBF1 6720
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 PRG2  
Affinity Capture-MS Homo sapiens
65 PI15  
Affinity Capture-MS Homo sapiens
66 TYW3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 CBLN4  
Affinity Capture-MS Homo sapiens
68 ZNF713  
Affinity Capture-MS Homo sapiens
69 LYZL1  
Affinity Capture-MS Homo sapiens
70 FBXO6 26270
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 ANKRD36B  
Affinity Capture-MS Homo sapiens
72 FOSL2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
73 ZNF777  
Affinity Capture-MS Homo sapiens
74 OGN 4969
Affinity Capture-MS Homo sapiens
75 FBXO2 26232
Affinity Capture-MS Homo sapiens
76 TFPI2 7980
Affinity Capture-MS Homo sapiens
77 HGF 3082
Affinity Capture-MS Homo sapiens
78 CDHR5 53841
Affinity Capture-MS Homo sapiens
79 EDN3  
Affinity Capture-MS Homo sapiens
80 LGALS8 3964
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
81 WNT2  
Affinity Capture-MS Homo sapiens
82 ZNF563  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
83 PRSS22 64063
Affinity Capture-MS Homo sapiens
84 APP 351
Affinity Capture-Western Homo sapiens
85 FGL1  
Affinity Capture-MS Homo sapiens
86 ZNF707  
Affinity Capture-MS Homo sapiens
87 PSG1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
88 SCGB1D1  
Affinity Capture-MS Homo sapiens
89 SALL4  
Affinity Capture-MS Homo sapiens
90 NDP  
Affinity Capture-MS Homo sapiens
91 ZNF264  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
92 MDK 4192
Affinity Capture-MS Homo sapiens
93 GCNT3 9245
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
94 DYRK3  
Affinity Capture-MS Homo sapiens
95 ASIP  
Affinity Capture-MS Homo sapiens
96 SCRT1 83482
Affinity Capture-MS Homo sapiens
97 CTSG 1511
Affinity Capture-MS Homo sapiens
98 SKP1 6500
Affinity Capture-MS Homo sapiens
99 ZNF816  
Affinity Capture-MS Homo sapiens
100 ZNF549  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
101 OS9 10956
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
102 SP6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
103 FST 10468
Affinity Capture-MS Homo sapiens
104 LRPAP1 4043
Co-purification Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
105 EGFL6 25975
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
106 HLA-DPA1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
107 NTN5  
Affinity Capture-MS Homo sapiens
108 SPPL2B 56928
Affinity Capture-MS Homo sapiens
109 GLI4  
Affinity Capture-MS Homo sapiens
110 ZNF517  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
111 ZNF284  
Affinity Capture-MS Homo sapiens
112 DEFB123  
Affinity Capture-MS Homo sapiens
113 HOXC12  
Affinity Capture-MS Homo sapiens
114 WISP3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
115 ZNF169 169841
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
116 RPL36AL 6166
Affinity Capture-MS Homo sapiens
117 ZNF331  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
118 HSPA12A 259217
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Co-localization Homo sapiens
119 SP7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
120 TIMP3 7078
Affinity Capture-MS Homo sapiens
121 ZNF26  
Affinity Capture-MS Homo sapiens
122 GREM2 64388
Affinity Capture-MS Homo sapiens
123 TRAF1 7185
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SORL1 is involved
PathwayEvidenceSource
Amyloid fiber formation TAS Reactome
Metabolism of proteins TAS Reactome





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