Gene description for SDF2L1
Gene name stromal cell-derived factor 2-like 1
Gene symbol SDF2L1
Other names/aliases -
Species Homo sapiens
 Database cross references - SDF2L1
ExoCarta ExoCarta_23753
Vesiclepedia VP_23753
Entrez Gene 23753
HGNC 10676
MIM 607551
UniProt Q9HCN8  
 SDF2L1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
 Gene ontology annotations for SDF2L1
Molecular Function
    protein binding GO:0005515 IPI
    protein-folding chaperone binding GO:0051087 IEA
    ATPase binding GO:0051117 IEA
    misfolded protein binding GO:0051787 IDA
Biological Process
    ERAD pathway GO:0036503 IEA
    regulation of apoptotic process GO:0042981 IEA
    chaperone cofactor-dependent protein refolding GO:0051085 IMP
    cellular response to misfolded protein GO:0071218 IEA
Subcellular Localization
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum lumen GO:0005788 IEA
    membrane GO:0016020 IEA
    endoplasmic reticulum chaperone complex GO:0034663 IEA
    protein folding chaperone complex GO:0101031 IPI
 Experiment description of studies that identified SDF2L1 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 207
MISEV standards
EM
Biophysical techniques
TSG101|HSP70|FLOT1
Enriched markers
VDAC
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DKO-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
6
Experiment ID 208
MISEV standards
EM
Biophysical techniques
TSG101|HSP70|FLOT1
Enriched markers
VDAC
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name Dks-8
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 209
MISEV standards
Biophysical techniques
TSG101|HSP70|FLOT1
Enriched markers
VDAC
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DLD-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SDF2L1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DCBLD2 131566
Affinity Capture-MS Homo sapiens
2 HFE  
Affinity Capture-MS Homo sapiens
3 SGSH 6448
Affinity Capture-MS Homo sapiens
4 SEMA4D  
Affinity Capture-MS Homo sapiens
5 ANKLE2 23141
Affinity Capture-MS Homo sapiens
6 SPRTN  
Affinity Capture-MS Homo sapiens
7 TOR1A 1861
Affinity Capture-MS Homo sapiens
8 CNTNAP3  
Affinity Capture-MS Homo sapiens
9 MAN2B1 4125
Affinity Capture-MS Homo sapiens
10 SCNN1A  
Affinity Capture-MS Homo sapiens
11 SORL1 6653
Affinity Capture-MS Homo sapiens
12 FGD2 221472
Affinity Capture-MS Homo sapiens
13 CACNA2D2 9254
Affinity Capture-MS Homo sapiens
14 C3orf58 205428
Affinity Capture-MS Homo sapiens
15 SEMA6B 10501
Affinity Capture-MS Homo sapiens
16 DNAJC16  
Affinity Capture-MS Homo sapiens
17 WNT7A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 EMID1  
Affinity Capture-MS Homo sapiens
19 NUBPL 80224
Affinity Capture-MS Homo sapiens
20 PROS1 5627
Affinity Capture-MS Homo sapiens
21 PLD4  
Affinity Capture-MS Homo sapiens
22 TNFRSF6B  
Affinity Capture-MS Homo sapiens
23 PLXNA3 55558
Affinity Capture-MS Homo sapiens
24 TMEM67 91147
Affinity Capture-MS Homo sapiens
25 ADAMTS2 9509
Affinity Capture-MS Homo sapiens
26 LNPEP 4012
Affinity Capture-MS Homo sapiens
27 RET 5979
Affinity Capture-MS Homo sapiens
28 GPR110  
Affinity Capture-MS Homo sapiens
29 THSD4 79875
Affinity Capture-MS Homo sapiens
30 ADAM19 8728
Affinity Capture-MS Homo sapiens
31 POMGNT2  
Affinity Capture-MS Homo sapiens
32 FGFR3 2261
Affinity Capture-MS Homo sapiens
33 MFGE8 4240
Affinity Capture-MS Homo sapiens
34 Spire2  
Affinity Capture-MS Mus musculus
35 MGAT5 4249
Affinity Capture-MS Homo sapiens
36 LAMC1 3915
Affinity Capture-MS Homo sapiens
37 HYAL1 3373
Affinity Capture-MS Homo sapiens
38 UXS1 80146
Affinity Capture-MS Homo sapiens
39 B4GALT4 8702
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 B3GNT2 10678
Affinity Capture-MS Homo sapiens
41 HLA-DRB3 3125
Affinity Capture-MS Homo sapiens
42 SCARA3  
Affinity Capture-MS Homo sapiens
43 LRP6 4040
Affinity Capture-MS Homo sapiens
44 GLG1 2734
Affinity Capture-MS Homo sapiens
45 LRP5 4041
Affinity Capture-MS Homo sapiens
46 MCM2 4171
Affinity Capture-MS Homo sapiens
47 ADGRG1 9289
Affinity Capture-MS Homo sapiens
48 ADAM9 8754
Affinity Capture-MS Homo sapiens
49 ASIC1  
Affinity Capture-MS Homo sapiens
50 JMJD8  
Affinity Capture-MS Homo sapiens
51 NAGA 4668
Affinity Capture-MS Homo sapiens
52 HYAL2 8692
Affinity Capture-MS Homo sapiens
53 DSC2 1824
Affinity Capture-MS Homo sapiens
54 FGFR4 2264
Affinity Capture-MS Homo sapiens
55 ADAM15 8751
Affinity Capture-MS Homo sapiens
56 MST1R 4486
Affinity Capture-MS Homo sapiens
57 SUSD2 56241
Affinity Capture-MS Homo sapiens
58 ENTPD2 954
Affinity Capture-MS Homo sapiens
59 VWA1 64856
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 SEPN1 57190
Affinity Capture-MS Homo sapiens
61 PSG8  
Affinity Capture-MS Homo sapiens
62 SUN2 25777
Affinity Capture-MS Homo sapiens
63 Cbx4  
Affinity Capture-MS Mus musculus
64 DGCR2 9993
Affinity Capture-MS Homo sapiens
65 GUSB 2990
Affinity Capture-MS Homo sapiens
66 F10 2159
Affinity Capture-MS Homo sapiens
67 EOGT 285203
Affinity Capture-MS Homo sapiens
68 TOR3A 64222
Affinity Capture-MS Homo sapiens
69 IL17RA 23765
Affinity Capture-MS Homo sapiens
70 EMC7 56851
Affinity Capture-MS Homo sapiens
71 GPX8 493869
Affinity Capture-MS Homo sapiens
72 TLL2  
Affinity Capture-MS Homo sapiens
73 TMEM2 23670
Affinity Capture-MS Homo sapiens
74 P4HTM  
Affinity Capture-MS Homo sapiens
75 COL6A2 1292
Affinity Capture-MS Homo sapiens
76 P3H4 10609
Affinity Capture-MS Homo sapiens
77 CNTNAP3B  
Affinity Capture-MS Homo sapiens
78 CHST12 55501
Affinity Capture-MS Homo sapiens
79 PRF1  
Affinity Capture-MS Homo sapiens
80 WNT3A 89780
Affinity Capture-MS Homo sapiens
81 Nup188  
Affinity Capture-MS Mus musculus
82 ERVMER34-1  
Affinity Capture-MS Homo sapiens
83 PLAUR 5329
Affinity Capture-MS Homo sapiens
84 MSLN 10232
Affinity Capture-MS Homo sapiens
85 EMC10 284361
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
86 HS2ST1 9653
Affinity Capture-MS Homo sapiens
87 SDF2 6388
Affinity Capture-MS Homo sapiens
88 BMP4 652
Affinity Capture-MS Homo sapiens
89 LRIG2  
Affinity Capture-MS Homo sapiens
90 IGF1R 3480
Affinity Capture-MS Homo sapiens
91 CLSTN1 22883
Affinity Capture-MS Homo sapiens
92 PCSK5 5125
Affinity Capture-MS Homo sapiens
93 TMEM43 79188
Affinity Capture-MS Homo sapiens
94 GALNT12 79695
Affinity Capture-MS Homo sapiens
95 TMTC3 160418
Affinity Capture-MS Homo sapiens
96 CHPF2 54480
Affinity Capture-MS Homo sapiens
97 MANBA 4126
Affinity Capture-MS Homo sapiens
98 PROZ 8858
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
99 CSPG4 1464
Affinity Capture-MS Homo sapiens
100 PBXIP1 57326
Affinity Capture-MS Homo sapiens
101 FIBIN  
Affinity Capture-MS Homo sapiens
102 OAF 220323
Affinity Capture-MS Homo sapiens
103 PIGT 51604
Affinity Capture-MS Homo sapiens
104 WNT5A 7474
Affinity Capture-MS Homo sapiens
105 TCTN2  
Affinity Capture-MS Homo sapiens
106 MIA3 375056
Affinity Capture-MS Homo sapiens
107 NOMO3 408050
Affinity Capture-MS Homo sapiens
108 CDHR4  
Affinity Capture-MS Homo sapiens
109 FBXL6  
Affinity Capture-MS Homo sapiens
110 PCBP3 54039
Affinity Capture-MS Homo sapiens
111 EXT2 2132
Affinity Capture-MS Homo sapiens
112 ART5  
Affinity Capture-MS Homo sapiens
113 GALNS 2588
Affinity Capture-MS Homo sapiens
114 RRP1B 23076
Affinity Capture-MS Homo sapiens
115 TMEM131  
Affinity Capture-MS Homo sapiens
116 PTPRO 5800
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
117 ATRN 8455
Affinity Capture-MS Homo sapiens
118 MAN2A2 4122
Affinity Capture-MS Homo sapiens
119 DNAJB11 51726
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
120 CERCAM 51148
Affinity Capture-MS Homo sapiens
121 TXNDC11 51061
Affinity Capture-MS Homo sapiens
122 EPHB4 2050
Affinity Capture-MS Homo sapiens
123 PAPLN  
Affinity Capture-MS Homo sapiens
124 LY86  
Affinity Capture-MS Homo sapiens
125 VCAN 1462
Affinity Capture-MS Homo sapiens
126 SNX1 6642
Affinity Capture-MS Homo sapiens
127 MEGF8 1954
Affinity Capture-MS Homo sapiens
128 MBTPS1 8720
Affinity Capture-MS Homo sapiens
129 LAMC3  
Affinity Capture-MS Homo sapiens
130 APLP2 334
Affinity Capture-MS Homo sapiens
131 HSPA5 3309
Affinity Capture-MS Homo sapiens
132 ADAM17 6868
Affinity Capture-MS Homo sapiens
133 MAN2B2 23324
Affinity Capture-MS Homo sapiens
134 TMEM30A 55754
Affinity Capture-MS Homo sapiens
135 EMC3 55831
Affinity Capture-MS Homo sapiens
136 LOXL2 4017
Affinity Capture-MS Homo sapiens
137 CANX 821
Affinity Capture-MS Homo sapiens
138 CD151 977
Affinity Capture-MS Homo sapiens
139 PCSK6 5046
Affinity Capture-MS Homo sapiens
140 AMBRA1  
Affinity Capture-MS Homo sapiens
141 SLC2A4  
Affinity Capture-MS Homo sapiens
142 PCDH1 5097
Affinity Capture-MS Homo sapiens
143 SLC39A6 25800
Affinity Capture-MS Homo sapiens
144 ADAMTS7  
Affinity Capture-MS Homo sapiens
145 RNF128  
Affinity Capture-MS Homo sapiens
146 CNTNAP1 8506
Affinity Capture-MS Homo sapiens
147 B3GNT3 10331
Affinity Capture-MS Homo sapiens
148 METRNL 284207
Affinity Capture-MS Homo sapiens
149 LRFN3  
Affinity Capture-MS Homo sapiens
150 CUL3 8452
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
151 NR3C1 2908
Proximity Label-MS Homo sapiens
152 STIM1 6786
Affinity Capture-MS Homo sapiens
153 SRSF5 6430
Co-fractionation Homo sapiens
154 EGFR 1956
Affinity Capture-MS Homo sapiens
155 NAGLU 4669
Affinity Capture-MS Homo sapiens
156 FBXO6 26270
Affinity Capture-MS Homo sapiens
157 H6PD 9563
Affinity Capture-MS Homo sapiens
158 LAMA5 3911
Affinity Capture-MS Homo sapiens
159 RIPK4  
Affinity Capture-MS Homo sapiens
160 SUZ12  
Affinity Capture-MS Homo sapiens
161 ECE1 1889
Affinity Capture-MS Homo sapiens
162 FRAS1 80144
Affinity Capture-MS Homo sapiens
163 PLXNB2 23654
Affinity Capture-MS Homo sapiens
164 MGRN1 23295
Affinity Capture-MS Homo sapiens
165 CTSG 1511
Affinity Capture-MS Homo sapiens
166 SGTB  
Two-hybrid Homo sapiens
167 MYCN  
Affinity Capture-MS Homo sapiens
168 BIRC6 57448
Affinity Capture-MS Homo sapiens
169 Sept2  
Affinity Capture-MS Mus musculus
170 FUT11 170384
Affinity Capture-MS Homo sapiens
171 JAG2  
Affinity Capture-MS Homo sapiens
172 MYC  
Affinity Capture-MS Homo sapiens
173 CRLF1 9244
Affinity Capture-MS Homo sapiens
174 CLIC1 1192
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
175 CHRD  
Affinity Capture-MS Homo sapiens
176 POTEE 445582
Affinity Capture-MS Homo sapiens
177 HLA-F 3134
Affinity Capture-MS Homo sapiens
178 TTC17 55761
Affinity Capture-MS Homo sapiens
179 CLPTM1 1209
Affinity Capture-MS Homo sapiens
180 SEZ6L2 26470
Affinity Capture-MS Homo sapiens
181 DNAJC3 5611
Proximity Label-MS Homo sapiens
182 P3H3 10536
Affinity Capture-MS Homo sapiens
183 PXDN 7837
Affinity Capture-MS Homo sapiens
184 SGTA 6449
Two-hybrid Homo sapiens
185 HLA-DQB1 3119
Affinity Capture-MS Homo sapiens
186 PCSK9 255738
Affinity Capture-MS Homo sapiens
187 PTPRU  
Affinity Capture-MS Homo sapiens
188 POGLUT1 56983
Affinity Capture-MS Homo sapiens
189 BMP1 649
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
190 TMTC2  
Affinity Capture-MS Homo sapiens
191 CTAGE5 4253
Affinity Capture-MS Homo sapiens
192 HMGB1P1 10357
Affinity Capture-MS Homo sapiens
193 SNX5 27131
Affinity Capture-MS Homo sapiens
194 ZPLD1  
Affinity Capture-MS Homo sapiens
195 Lgals3bp 19039
Affinity Capture-MS Mus musculus
196 ADAM10 102
Affinity Capture-MS Homo sapiens
197 TTC13  
Affinity Capture-MS Homo sapiens
198 SEL1L3  
Affinity Capture-MS Homo sapiens
199 LAMB1 3912
Affinity Capture-MS Homo sapiens
200 VWDE  
Affinity Capture-MS Homo sapiens
201 SUN1 23353
Affinity Capture-MS Homo sapiens
202 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
203 NRROS  
Affinity Capture-MS Homo sapiens
204 NAAA  
Affinity Capture-MS Homo sapiens
205 TERF2  
Affinity Capture-MS Homo sapiens
206 TIMP1 7076
Affinity Capture-MS Homo sapiens
207 ABCA2 20
Affinity Capture-MS Homo sapiens
208 PSG1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
209 GYLTL1B 120071
Affinity Capture-MS Homo sapiens
210 PDIA5 10954
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
211 FOXRED2  
Affinity Capture-MS Homo sapiens
212 ENTPD6  
Affinity Capture-MS Homo sapiens
213 NXPH4  
Affinity Capture-MS Homo sapiens
214 METRN 79006
Affinity Capture-MS Homo sapiens
215 PDIA4 9601
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
216 CALU 813
Proximity Label-MS Homo sapiens
217 ADAM33 80332
Affinity Capture-MS Homo sapiens
218 SEMA3C 10512
Affinity Capture-MS Homo sapiens
219 MFI2 4241
Affinity Capture-MS Homo sapiens
220 PLXNA1 5361
Affinity Capture-MS