Gene description for TOR3A
Gene name torsin family 3, member A
Gene symbol TOR3A
Other names/aliases ADIR
ADIR2
Species Homo sapiens
 Database cross references - TOR3A
ExoCarta ExoCarta_64222
Vesiclepedia VP_64222
Entrez Gene 64222
HGNC 11997
MIM 607555
UniProt Q9H497  
 TOR3A identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Endothelial cells 26027894    
Saliva 19199708    
 Gene ontology annotations for TOR3A
Molecular Function
    ATP binding GO:0005524 IEA
    ATP hydrolysis activity GO:0016887 IDA
Subcellular Localization
    nuclear envelope GO:0005635 IBA
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum lumen GO:0005788 IBA
    endoplasmic reticulum lumen GO:0005788 IDA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified TOR3A in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 226
MISEV standards
✔
EM
Biophysical techniques
✔
GAPDH|CD9|FLOT1
Enriched markers
✔
LMNA|H2AFX|ATP5A1|TOMM20
Negative markers
✘ Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description "Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting"
Authors "Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar"
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
6
Experiment ID 66
MISEV standards
✔
IEM
Biophysical techniques
✔
TSG101|Alix|CD63|CD81
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors "Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR"
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for TOR3A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 P3H1 64175
Affinity Capture-MS Homo sapiens
2 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
3 C7orf34  
Affinity Capture-MS Homo sapiens
4 GPIHBP1  
Affinity Capture-MS Homo sapiens
5 CKAP4 10970
Affinity Capture-MS Homo sapiens
6 ELSPBP1  
Affinity Capture-MS Homo sapiens
7 OMA1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 CHST5  
Affinity Capture-MS Homo sapiens
9 TOR1A 1861
Affinity Capture-MS Homo sapiens
10 LGI1  
Affinity Capture-MS Homo sapiens
11 CLGN 1047
Affinity Capture-MS Homo sapiens
12 FAM20C 56975
Affinity Capture-MS Homo sapiens
13 ECEL1  
Affinity Capture-MS Homo sapiens
14 TMEM87A 25963
Affinity Capture-MS Homo sapiens
15 IGHD  
Affinity Capture-MS Homo sapiens
16 METRN 79006
Affinity Capture-MS Homo sapiens
17 FAM57A  
Affinity Capture-MS Homo sapiens
18 TAZ  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 DNASE2B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 CHST8 64377
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 ADAM33 80332
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 TMPRSS3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 NCR3  
Affinity Capture-MS Homo sapiens
24 IFNE  
Affinity Capture-MS Homo sapiens
25 CFC1  
Affinity Capture-MS Homo sapiens
26 FGF4  
Affinity Capture-MS Homo sapiens
27 TMEM106C 79022
Affinity Capture-MS Homo sapiens
28 PRG2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 PRSS50  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 PI15  
Affinity Capture-MS Homo sapiens
31 CLEC12B  
Affinity Capture-MS Homo sapiens
32 LYZL1  
Affinity Capture-MS Homo sapiens
33 CEACAM21  
Affinity Capture-MS Homo sapiens
34 TIMP3 7078
Affinity Capture-MS Homo sapiens
35 CMA1  
Affinity Capture-MS Homo sapiens
36 OLFM4 10562
Affinity Capture-MS Homo sapiens
37 IL5RA  
Affinity Capture-MS Homo sapiens
38 HSPA5 3309
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 FUT3 2525
Affinity Capture-MS Homo sapiens
40 DPPA4  
Affinity Capture-MS Homo sapiens
41 TMEM43 79188
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 LMF1 64788
Affinity Capture-MS Homo sapiens
43 HPN  
Affinity Capture-MS Homo sapiens
44 TM2D3  
Affinity Capture-MS Homo sapiens
45 SUSD4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 ARSG 22901
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 SDF2L1 23753
Affinity Capture-MS Homo sapiens
48 CRLF1 9244
Affinity Capture-MS Homo sapiens
49 SCGB2A1 4246
Affinity Capture-MS Homo sapiens
50 TMPRSS13  
Affinity Capture-MS Homo sapiens
51 ADAMTS4  
Affinity Capture-MS Homo sapiens
52 KLKB1 3818
Affinity Capture-MS Homo sapiens
53 DNAJB9 4189
Affinity Capture-MS Homo sapiens
54 CRELD2 79174
Affinity Capture-MS Homo sapiens
55 ACRBP  
Affinity Capture-MS Homo sapiens
56 ANGPT4  
Affinity Capture-MS Homo sapiens
57 PCGF1 84759
Affinity Capture-MS Homo sapiens
58 RMDN3 55177
Affinity Capture-MS Homo sapiens
59 LEP  
Affinity Capture-MS Homo sapiens
60 B3GNT2 10678
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 F9 2158
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 POU5F1  
Affinity Capture-MS Homo sapiens
63 EDN3  
Affinity Capture-MS Homo sapiens
64 ST14 6768
Affinity Capture-MS Homo sapiens
65 TMPRSS5  
Affinity Capture-MS Homo sapiens
66 NOG 9241
Affinity Capture-MS Homo sapiens
67 NANOG  
Affinity Capture-MS Homo sapiens
68 MEX3A  
Affinity Capture-RNA Homo sapiens
69 CANX 821
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 LYPD4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 KLK15  
Affinity Capture-MS Homo sapiens
72 WNT16  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
73 GIP  
Affinity Capture-MS Homo sapiens
74 FOXS1  
Affinity Capture-MS Homo sapiens
75 CEACAM8 1088
Affinity Capture-MS Homo sapiens
76 IGFL3  
Affinity Capture-MS Homo sapiens
77 LIPG 9388
Affinity Capture-MS Homo sapiens
78 WRB 7485
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which TOR3A is involved
No pathways found





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