Gene description for METRN
Gene name meteorin, glial cell differentiation regulator
Gene symbol METRN
Other names/aliases C16orf23
c380A1.2
Species Homo sapiens
 Database cross references - METRN
ExoCarta ExoCarta_79006
Vesiclepedia VP_79006
Entrez Gene 79006
HGNC 14151
MIM 610998
UniProt Q9UJH8  
 METRN identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
Hepatocytes 26054723    
 Gene ontology annotations for METRN
Molecular Function
    hormone activity GO:0005179 IBA
Biological Process
    signal transduction GO:0007165 IEA
    axonogenesis GO:0007409 IEA
    glial cell differentiation GO:0010001 IBA
    positive regulation of axonogenesis GO:0050772 IBA
    radial glial cell differentiation GO:0060019 IEA
Subcellular Localization
    extracellular space GO:0005615 IBA
 Experiment description of studies that identified METRN in exosomes
1
Experiment ID 235
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
2
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for METRN
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 LY86  
Affinity Capture-MS Homo sapiens
2 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
3 CCL3  
Affinity Capture-MS Homo sapiens
4 LY6H  
Affinity Capture-MS Homo sapiens
5 C7orf34  
Affinity Capture-MS Homo sapiens
6 FMOD 2331
Affinity Capture-MS Homo sapiens
7 BTNL2  
Affinity Capture-MS Homo sapiens
8 TMEM106A  
Affinity Capture-MS Homo sapiens
9 SERPINA6  
Affinity Capture-MS Homo sapiens
10 TOR3A 64222
Affinity Capture-MS Homo sapiens
11 DNASE1L2  
Affinity Capture-MS Homo sapiens
12 PRSS2 5645
Affinity Capture-MS Homo sapiens
13 PRG2  
Affinity Capture-MS Homo sapiens
14 MFAP4 4239
Affinity Capture-MS Homo sapiens
15 PI15  
Affinity Capture-MS Homo sapiens
16 OIT3 170392
Affinity Capture-MS Homo sapiens
17 KLRD1  
Affinity Capture-MS Homo sapiens
18 MGAT4C  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 LYZL1  
Affinity Capture-MS Homo sapiens
20 P3H1 64175
Affinity Capture-MS Homo sapiens
21 DDX58 23586
Affinity Capture-RNA Homo sapiens
22 A2M 2
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 ELSPBP1  
Affinity Capture-MS Homo sapiens
24 SFTPC  
Affinity Capture-MS Homo sapiens
25 CELA3A  
Affinity Capture-MS Homo sapiens
26 GAA 2548
Affinity Capture-MS Homo sapiens
27 C1QB 713
Affinity Capture-MS Homo sapiens
28 ADIPOQ 9370
Affinity Capture-MS Homo sapiens
29 BRICD5  
Affinity Capture-MS Homo sapiens
30 SDF2L1 23753
Affinity Capture-MS Homo sapiens
31 FIBIN  
Affinity Capture-MS Homo sapiens
32 CGREF1 10669
Affinity Capture-MS Homo sapiens
33 SCGB2A2  
Affinity Capture-MS Homo sapiens
34 DEFA5  
Affinity Capture-MS Homo sapiens
35 HTR2B  
Two-hybrid Homo sapiens
36 PTPRN  
Affinity Capture-MS Homo sapiens
37 EDN3  
Affinity Capture-MS Homo sapiens
38 DNASE1L1 1774
Affinity Capture-MS Homo sapiens
39 ISLR 3671
Affinity Capture-MS Homo sapiens
40 PTCH1  
Affinity Capture-MS Homo sapiens
41 BRINP1  
Affinity Capture-MS Homo sapiens
42 BMP4 652
Affinity Capture-MS Homo sapiens
43 SIRPD  
Affinity Capture-MS Homo sapiens
44 CRLF1 9244
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which METRN is involved
No pathways found





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