Gene description for ADIPOQ
Gene name adiponectin, C1Q and collagen domain containing
Gene symbol ADIPOQ
Other names/aliases ACDC
ACRP30
ADIPQTL1
ADPN
APM-1
APM1
GBP28
Species Homo sapiens
 Database cross references - ADIPOQ
ExoCarta ExoCarta_9370
Vesiclepedia VP_9370
Entrez Gene 9370
HGNC 13633
MIM 605441
UniProt Q15848  
 ADIPOQ identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for ADIPOQ
Molecular Function
    protein homodimerization activity GO:0042803 IPI
    identical protein binding GO:0042802 TAS
    receptor binding GO:0005102 ISS
    hormone activity GO:0005179 IDA
    cytokine activity GO:0005125 NAS
    sialic acid binding GO:0033691 IDA
    protein binding GO:0005515 IPI
Biological Process
    protein heterotrimerization GO:0070208 IEA
    negative regulation of tumor necrosis factor-mediated signaling pathway GO:0010804 IDA
    negative regulation of low-density lipoprotein particle receptor biosynthetic process GO:0045715 IDA
    response to tumor necrosis factor GO:0034612 IDA
    positive regulation of glycogen (starch) synthase activity GO:2000467 ISS
    negative regulation of synaptic transmission GO:0050805 IDA
    adiponectin-activated signaling pathway GO:0033211 IEA
    membrane hyperpolarization GO:0060081 IEA
    positive regulation of cAMP-dependent protein kinase activity GO:2000481 IDA
    positive regulation of signal transduction GO:0009967 ISS
    response to glucocorticoid GO:0051384 IEA
    negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0043124 IDA
    negative regulation of heterotypic cell-cell adhesion GO:0034115 IDA
    response to glucose GO:0009749 ISS
    negative regulation of DNA biosynthetic process GO:2000279 IDA
    negative regulation of macrophage differentiation GO:0045650 IDA
    positive regulation of metanephric glomerular visceral epithelial cell development GO:2000478 ISS
    negative regulation of MAP kinase activity GO:0043407 ISS
    negative regulation of gluconeogenesis GO:0045721 ISS
    positive regulation of myeloid cell apoptotic process GO:0033034 IDA
    negative regulation of platelet-derived growth factor receptor-alpha signaling pathway GO:2000584 ISS
    negative regulation of macrophage derived foam cell differentiation GO:0010745 IDA
    negative regulation of granulocyte differentiation GO:0030853 IDA
    positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IEA
    positive regulation of protein phosphorylation GO:0001934 IDA
    negative regulation of cell migration GO:0030336 ISS
    positive regulation of monocyte chemotactic protein-1 production GO:0071639 IDA
    membrane depolarization GO:0051899 IEA
    response to nutrient GO:0007584 IEA
    negative regulation of smooth muscle cell proliferation GO:0048662 IDA
    response to activity GO:0014823 IEA
    cellular response to drug GO:0035690 ISS
    glucose homeostasis GO:0042593 ISS
    positive regulation of blood pressure GO:0045777 IEA
    generation of precursor metabolites and energy GO:0006091 TAS
    negative regulation of intracellular protein transport GO:0090317 IDA
    cellular response to epinephrine stimulus GO:0071872 IEA
    negative regulation of fat cell differentiation GO:0045599 IDA
    fatty acid beta-oxidation GO:0006635 ISS
    positive regulation of cellular protein metabolic process GO:0032270 IDA
    negative regulation of ERK1 and ERK2 cascade GO:0070373 IDA
    negative regulation of receptor binding GO:1900121 IDA
    response to ethanol GO:0045471 IEA
    positive regulation of protein kinase A signaling GO:0010739 IDA
    positive regulation of cholesterol efflux GO:0010875 IDA
    negative regulation of blood pressure GO:0045776 IDA
    positive regulation of interleukin-8 production GO:0032757 IDA
    negative regulation of smooth muscle cell migration GO:0014912 IDA
    circadian rhythm GO:0007623 IEA
    protein homooligomerization GO:0051260 ISS
    detection of oxidative stress GO:0070994 ISS
    brown fat cell differentiation GO:0050873 ISS
    fatty acid oxidation GO:0019395 ISS
    negative regulation of protein autophosphorylation GO:0031953 IDA
    response to hypoxia GO:0001666 IEA
    response to linoleic acid GO:0070543 IEA
    cellular response to insulin stimulus GO:0032869 ISS
    protein localization to plasma membrane GO:0072659 IDA
    positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 ISS
    negative regulation of transcription, DNA-templated GO:0045892 IDA
    negative regulation of phagocytosis GO:0050765 IDA
    positive regulation of glucose import GO:0046326 ISS
    regulation of glucose metabolic process GO:0010906 IDA
    negative regulation of platelet-derived growth factor receptor signaling pathway GO:0010642 IDA
    negative regulation of hormone secretion GO:0046888 IEA
    low-density lipoprotein particle clearance GO:0034383 IDA
    positive regulation of fatty acid metabolic process GO:0045923 ISS
    negative regulation of inflammatory response GO:0050728 NAS
    cellular response to cAMP GO:0071320 IEA
    negative regulation of metanephric mesenchymal cell migration GO:2000590 ISS
    glucose metabolic process GO:0006006 ISS
    negative regulation of tumor necrosis factor production GO:0032720 IDA
    response to sucrose GO:0009744 IEA
    positive regulation of renal albumin absorption GO:2000534 IDA
Subcellular Localization
    cell surface GO:0009986 IDA
    endoplasmic reticulum GO:0005783 ISS
    extracellular exosome GO:0070062 IDA
    extracellular region GO:0005576 TAS
    collagen trimer GO:0005581 IEA
    extracellular space GO:0005615 IDA
 Experiment description of studies that identified ADIPOQ in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for ADIPOQ
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ADIPOQ is involved
PathwayEvidenceSource
Transcriptional regulation of white adipocyte differentiation TAS Reactome





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