Gene description for ADIPOQ
Gene name adiponectin, C1Q and collagen domain containing
Gene symbol ADIPOQ
Other names/aliases ACDC
ACRP30
ADIPQTL1
ADPN
APM-1
APM1
GBP28
Species Homo sapiens
 Database cross references - ADIPOQ
ExoCarta ExoCarta_9370
Vesiclepedia VP_9370
Entrez Gene 9370
HGNC 13633
MIM 605441
UniProt Q15848  
 ADIPOQ identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for ADIPOQ
Molecular Function
    signaling receptor binding GO:0005102 ISS
    cytokine activity GO:0005125 NAS
    hormone activity GO:0005179 IDA
    extracellular matrix structural constituent GO:0005201 RCA
    protein binding GO:0005515 IPI
    sialic acid binding GO:0033691 IDA
    protein homodimerization activity GO:0042803 IPI
    protein serine/threonine kinase activator activity GO:0043539 IEA
Biological Process
    response to hypoxia GO:0001666 IEA
    positive regulation of protein phosphorylation GO:0001934 IDA
    glucose metabolic process GO:0006006 ISS
    generation of precursor metabolites and energy GO:0006091 TAS
    fatty acid beta-oxidation GO:0006635 ISS
    signal transduction GO:0007165 IEA
    response to nutrient GO:0007584 IEA
    circadian rhythm GO:0007623 IEA
    response to bacterium GO:0009617 IEA
    response to sucrose GO:0009744 IEA
    response to glucose GO:0009749 ISS
    positive regulation of signal transduction GO:0009967 ISS
    gene expression GO:0010467 IEA
    negative regulation of platelet-derived growth factor receptor signaling pathway GO:0010642 IDA
    negative regulation of macrophage derived foam cell differentiation GO:0010745 IDA
    negative regulation of tumor necrosis factor-mediated signaling pathway GO:0010804 IDA
    positive regulation of cholesterol efflux GO:0010875 IDA
    regulation of glucose metabolic process GO:0010906 IDA
    response to activity GO:0014823 IEA
    fatty acid oxidation GO:0019395 ISS
    negative regulation of cell migration GO:0030336 ISS
    negative regulation of granulocyte differentiation GO:0030853 IDA
    negative regulation of protein autophosphorylation GO:0031953 IDA
    negative regulation of tumor necrosis factor production GO:0032720 IDA
    positive regulation of interleukin-8 production GO:0032757 IDA
    cellular response to insulin stimulus GO:0032869 ISS
    positive regulation of myeloid cell apoptotic process GO:0033034 IDA
    negative regulation of heterotypic cell-cell adhesion GO:0034115 IDA
    low-density lipoprotein particle clearance GO:0034383 IDA
    response to tumor necrosis factor GO:0034612 IDA
    glucose homeostasis GO:0042593 ISS
    positive regulation of canonical NF-kappaB signal transduction GO:0043123 ISS
    negative regulation of canonical NF-kappaB signal transduction GO:0043124 IDA
    negative regulation of MAP kinase activity GO:0043407 ISS
    response to ethanol GO:0045471 IEA
    negative regulation of fat cell differentiation GO:0045599 IDA
    negative regulation of macrophage differentiation GO:0045650 IDA
    negative regulation of gluconeogenesis GO:0045721 ISS
    negative regulation of blood pressure GO:0045776 IDA
    negative regulation of DNA-templated transcription GO:0045892 IDA
    positive regulation of fatty acid metabolic process GO:0045923 ISS
    positive regulation of D-glucose import GO:0046326 ISS
    negative regulation of hormone secretion GO:0046888 IEA
    negative regulation of inflammatory response GO:0050728 ISS
    negative regulation of inflammatory response GO:0050728 NAS
    positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IEA
    negative regulation of phagocytosis GO:0050765 IDA
    negative regulation of synaptic transmission GO:0050805 IDA
    brown fat cell differentiation GO:0050873 ISS
    response to glucocorticoid GO:0051384 IEA
    negative regulation of ERK1 and ERK2 cascade GO:0070373 IDA
    response to linoleic acid GO:0070543 IEA
    detection of oxidative stress GO:0070994 ISS
    cellular response to cAMP GO:0071320 IEA
    cellular response to xenobiotic stimulus GO:0071466 ISS
    positive regulation of monocyte chemotactic protein-1 production GO:0071639 IDA
    cellular response to epinephrine stimulus GO:0071872 IEA
    protein localization to plasma membrane GO:0072659 IDA
    negative regulation of intracellular protein transport GO:0090317 IDA
    positive regulation of lipid transporter activity GO:0110113 IDA
    positive regulation of cold-induced thermogenesis GO:0120162 ISS
    negative regulation of cold-induced thermogenesis GO:0120163 ISS
    positive regulation of cAMP/PKA signal transduction GO:0141163 IDA
    negative regulation of receptor binding GO:1900121 IDA
    negative regulation of vascular associated smooth muscle cell proliferation GO:1904706 IDA
    negative regulation of vascular associated smooth muscle cell migration GO:1904753 IDA
    negative regulation of low-density lipoprotein receptor activity GO:1905598 IDA
    negative regulation of DNA biosynthetic process GO:2000279 IDA
    positive regulation of glycogen (starch) synthase activity GO:2000467 ISS
    positive regulation of metanephric podocyte development GO:2000478 ISS
    positive regulation of cAMP-dependent protein kinase activity GO:2000481 IDA
    positive regulation of renal albumin absorption GO:2000534 IDA
    negative regulation of platelet-derived growth factor receptor-alpha signaling pathway GO:2000584 ISS
    negative regulation of metanephric mesenchymal cell migration GO:2000590 ISS
Subcellular Localization
    extracellular region GO:0005576 HDA
    extracellular region GO:0005576 TAS
    collagen trimer GO:0005581 IEA
    extracellular space GO:0005615 IDA
    endoplasmic reticulum GO:0005783 ISS
    cell surface GO:0009986 IDA
    collagen-containing extracellular matrix GO:0062023 HDA
 Experiment description of studies that identified ADIPOQ in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for ADIPOQ
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 COL14A1 7373
Affinity Capture-MS Homo sapiens
2 DNLZ  
Affinity Capture-MS Homo sapiens
3 PRKAA1 5562
Affinity Capture-MS Homo sapiens
4 ERN1  
Affinity Capture-MS Homo sapiens
5 PEX12  
Two-hybrid Homo sapiens
6 MTPAP 55149
Affinity Capture-MS Homo sapiens
7 ASGR2  
Two-hybrid Homo sapiens
8 PROS1 5627
Affinity Capture-MS Homo sapiens
9 SYNE4  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
10 HSD17B11 51170
Two-hybrid Homo sapiens
11 BNIP3L  
Two-hybrid Homo sapiens
12 VHL  
Affinity Capture-MS Homo sapiens
13 KEL  
Two-hybrid Homo sapiens
14 CD79A  
Two-hybrid Homo sapiens
15 COL12A1 1303
Affinity Capture-MS Homo sapiens
16 MS4A3  
Two-hybrid Homo sapiens
17 AMIGO1  
Two-hybrid Homo sapiens
18 TMEM179B 374395
Two-hybrid Homo sapiens
19 TMPRSS2 7113
Two-hybrid Homo sapiens
20 TRIM35 23087
Two-hybrid Homo sapiens
21 MUC1 4582
Two-hybrid Homo sapiens
22 C1QTNF4  
Affinity Capture-MS Homo sapiens
23 OLFML2A  
Affinity Capture-MS Homo sapiens
24 NMU  
Affinity Capture-MS Homo sapiens
25 CLDN9  
Two-hybrid Homo sapiens
26 COLGALT2  
Affinity Capture-MS Homo sapiens
27 FCGR1A  
Two-hybrid Homo sapiens
28 CD200R1 131450
Two-hybrid Homo sapiens
29 P3H4 10609
Affinity Capture-MS Homo sapiens
30 CAMLG 819
Two-hybrid Homo sapiens
31 CHID1 66005
Affinity Capture-MS Homo sapiens
32 EMC10 284361
Affinity Capture-MS Homo sapiens
33 TRIM7  
Affinity Capture-MS Homo sapiens
34 MFSD6 54842
Two-hybrid Homo sapiens
35 PLOD2 5352
Affinity Capture-MS Homo sapiens
36 C1QL1  
Affinity Capture-MS Homo sapiens
37 CCDC107  
Two-hybrid Homo sapiens
38 SLC22A23  
Two-hybrid Homo sapiens
39 HIATL1 84641
Two-hybrid Homo sapiens
40 SLC35E3  
Two-hybrid Homo sapiens
41 SCN3B  
Two-hybrid Homo sapiens
42 C17orf62 79415
Two-hybrid Homo sapiens
43 MFF 56947
Two-hybrid Homo sapiens
44 TMEM35  
Two-hybrid Homo sapiens
45 MRM1  
Two-hybrid Homo sapiens
46 HSPA5 3309
Affinity Capture-MS Homo sapiens
47 FNDC9  
Two-hybrid Homo sapiens
48 EMC3 55831
Affinity Capture-MS Homo sapiens
49 BTNL9  
Two-hybrid Homo sapiens
50 WRNIP1 56897
Affinity Capture-MS Homo sapiens
51 B4GALT5 9334
Affinity Capture-MS Homo sapiens
52 PROKR2  
Two-hybrid Homo sapiens
53 METRNL 284207
Affinity Capture-MS Homo sapiens
54 SIGLEC12  
Two-hybrid Homo sapiens
55 CCDC155  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
56 TMEM194A  
Two-hybrid Homo sapiens
57 HOMER1  
Affinity Capture-MS Homo sapiens
58 CREB3L1  
Two-hybrid Homo sapiens
59 GPR152  
Two-hybrid Homo sapiens
60 SGTB  
Two-hybrid Homo sapiens
61 GPR42  
Two-hybrid Homo sapiens
62 ACSL3 2181
Affinity Capture-MS Homo sapiens
63 TMEM237 65062
Two-hybrid Homo sapiens
64 CHRD  
Affinity Capture-MS Homo sapiens
65 CPLX4  
Two-hybrid Homo sapiens
66 P3H3 10536
Affinity Capture-MS Homo sapiens
67 SGTA 6449
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
68 SEH1L 81929
Affinity Capture-MS Homo sapiens
69 BMP1 649
Affinity Capture-MS Homo sapiens
70 PDP1 54704
Affinity Capture-MS Homo sapiens
71 BMP4 652
Affinity Capture-MS Homo sapiens
72 IFNGR2  
Two-hybrid Homo sapiens
73 FASN 2194
Two-hybrid Homo sapiens
74 SYAP1 94056
Two-hybrid Homo sapiens
75 SLC16A2  
Two-hybrid Homo sapiens
76 METRN 79006
Affinity Capture-MS Homo sapiens
77 TNFSF14  
Two-hybrid Homo sapiens
78 EMC4 51234
Affinity Capture-MS Homo sapiens
79 FAM209A 200232
Two-hybrid Homo sapiens
80 COL18A1 80781
Affinity Capture-MS Homo sapiens
81 CLEC10A  
Two-hybrid Homo sapiens
82 ADIPOQ 9370
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
83 BSND  
Two-hybrid Homo sapiens
84 SHARPIN  
Affinity Capture-MS Homo sapiens
85 KCNK5  
Two-hybrid Homo sapiens
86 CNR2  
Two-hybrid Homo sapiens
87 C1QL4  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here