Gene description for TMEM237
Gene name transmembrane protein 237
Gene symbol TMEM237
Other names/aliases ALS2CR4
JBTS14
Species Homo sapiens
 Database cross references - TMEM237
ExoCarta ExoCarta_65062
Vesiclepedia VP_65062
Entrez Gene 65062
HGNC 14432
MIM 614423
UniProt Q96Q45  
 TMEM237 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Melanoma cells 25950383    
Melanoma cells 25950383    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for TMEM237
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    regulation of Wnt signaling pathway GO:0030111 IMP
    cilium assembly GO:0060271 IBA
    cilium assembly GO:0060271 IMP
Subcellular Localization
    membrane GO:0016020 HDA
    photoreceptor connecting cilium GO:0032391 IEA
    ciliary transition zone GO:0035869 IBA
    ciliary transition zone GO:0035869 IDA
    cone photoreceptor outer segment GO:0120199 IEA
    rod photoreceptor outer segment GO:0120200 IEA
 Experiment description of studies that identified TMEM237 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 254
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|FLOT1|CD81
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name MNT-1
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 257
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|FLOT1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name Daju
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
7
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
8
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for TMEM237
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 INSIG1  
Two-hybrid Homo sapiens
2 EFNA5  
Two-hybrid Homo sapiens
3 LOC100507537  
Two-hybrid Homo sapiens
4 SLC30A8  
Two-hybrid Homo sapiens
5 BPIFA1 51297
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 TMEM60  
Two-hybrid Homo sapiens
7 RXFP1  
Affinity Capture-MS Homo sapiens
8 ORMDL3 94103
Two-hybrid Homo sapiens
9 CD53 963
Two-hybrid Homo sapiens
10 SP1  
Co-fractionation Homo sapiens
11 TMEM147 10430
Two-hybrid Homo sapiens
12 SLC35B4  
Two-hybrid Homo sapiens
13 MFSD5  
Two-hybrid Homo sapiens
14 EPX 8288
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 CMTM6 54918
Affinity Capture-MS Homo sapiens
16 TMEFF2  
Two-hybrid Homo sapiens
17 APOD 347
Two-hybrid Homo sapiens
18 TMEM179B 374395
Two-hybrid Homo sapiens
19 RPRM  
Two-hybrid Homo sapiens
20 Emc3  
Affinity Capture-MS Mus musculus
21 GRM2 2912
Two-hybrid Homo sapiens
22 SLC41A1 254428
Two-hybrid Homo sapiens
23 C4orf3  
Two-hybrid Homo sapiens
24 STX8 9482
Two-hybrid Homo sapiens
25 CFHR5  
Two-hybrid Homo sapiens
26 TMEM201 199953
Two-hybrid Homo sapiens
27 Flot2 14252
Affinity Capture-MS Mus musculus
28 TM6SF2  
Two-hybrid Homo sapiens
29 LPAR3  
Two-hybrid Homo sapiens
30 C3orf52  
Two-hybrid Homo sapiens
31 CCDC47 57003
Affinity Capture-MS Homo sapiens
32 GUCA2A  
Two-hybrid Homo sapiens
33 SLC35G1  
Two-hybrid Homo sapiens
34 BET1 10282
Two-hybrid Homo sapiens
35 TMEM107 84314
Two-hybrid Homo sapiens
36 FZD7 8324
Two-hybrid Homo sapiens
37 SLC12A7 10723
Two-hybrid Homo sapiens
38 CLGN 1047
Affinity Capture-MS Homo sapiens
39 LEPROTL1 23484
Two-hybrid Homo sapiens
40 PRNP 5621
Reconstituted Complex Homo sapiens
41 INSIG2  
Two-hybrid Homo sapiens
42 AQP1 358
Two-hybrid Homo sapiens
43 OTOP3  
Two-hybrid Homo sapiens
44 GPR25  
Two-hybrid Homo sapiens
45 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
46 OPRD1  
Two-hybrid Homo sapiens
47 IGHA2 3494
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 NPHP1  
Affinity Capture-MS Homo sapiens
49 IGFBP5 3488
Two-hybrid Homo sapiens
50 SLC29A2 3177
Two-hybrid Homo sapiens
51 JAGN1 84522
Two-hybrid Homo sapiens
52 MFSD6 54842
Two-hybrid Homo sapiens
53 MCAM 4162
Proximity Label-MS Homo sapiens
54 DNAJC5 80331
Proximity Label-MS Homo sapiens
55 SLC39A2  
Two-hybrid Homo sapiens
56 EXTL1  
Two-hybrid Homo sapiens
57 MS4A13  
Two-hybrid Homo sapiens
58 TUSC5  
Two-hybrid Homo sapiens
59 C16orf58 64755
Two-hybrid Homo sapiens
60 SLC41A2 84102
Two-hybrid Homo sapiens
61 UNC93A  
Two-hybrid Homo sapiens
62 BPIFB1 92747
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 SLC2A5 6518
Two-hybrid Homo sapiens
64 TMEM56  
Two-hybrid Homo sapiens
65 Coro1c 23790
Affinity Capture-MS Mus musculus
66 MFF 56947
Two-hybrid Homo sapiens
67 ST6GAL2  
Two-hybrid Homo sapiens
68 SLC7A1 6541
Two-hybrid Homo sapiens
69 CLN6  
Two-hybrid Homo sapiens
70 MAT2A 4144
Co-fractionation Homo sapiens
71 LAT 27040
Two-hybrid Homo sapiens
72 GJB2  
Two-hybrid Homo sapiens
73 CYB5B 80777
Two-hybrid Homo sapiens
74 UPK1B 7348
Two-hybrid Homo sapiens
75 EMC6 83460
Two-hybrid Homo sapiens
76 CANX 821
Affinity Capture-MS Homo sapiens
77 ZFPL1 7542
Two-hybrid Homo sapiens
78 YIPF6 286451
Two-hybrid Homo sapiens
79 IGHA1 3493
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
80 ROBO2 6092
Two-hybrid Homo sapiens
81 TM4SF19  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
82 BLCAP  
Two-hybrid Homo sapiens
83 LAMP1 3916
Proximity Label-MS Homo sapiens
84 Bmpr1a  
Affinity Capture-MS Mus musculus
85 GOLT1B 51026
Affinity Capture-MS Homo sapiens
86 TMEM128  
Two-hybrid Homo sapiens
87 VEGFA 7422
Two-hybrid Homo sapiens
88 FXYD6  
Two-hybrid Homo sapiens
89 SERPINE1 5054
Two-hybrid Homo sapiens
90 TMEM42  
Two-hybrid Homo sapiens
91 ARF6 382
Proximity Label-MS Homo sapiens
92 SLC7A3  
Two-hybrid Homo sapiens
93 TMEM11 8834
Two-hybrid Homo sapiens
94 SLC16A4  
Two-hybrid Homo sapiens
95 SLC35B2 347734
Two-hybrid Homo sapiens
96 TMEM86B  
Two-hybrid Homo sapiens
97 SERP2  
Two-hybrid Homo sapiens
98 GPR42  
Two-hybrid Homo sapiens
99 FAM134C 162427
Two-hybrid Homo sapiens
100 Flnb 286940
Affinity Capture-MS Mus musculus
101 OTOP2  
Two-hybrid Homo sapiens
102 SLC35A4  
Two-hybrid Homo sapiens
103 SFXN5  
Two-hybrid Homo sapiens
104 GIF  
Two-hybrid Homo sapiens
105 TMEM72  
Two-hybrid Homo sapiens
106 TMEM144  
Two-hybrid Homo sapiens
107 CXCL9  
Two-hybrid Homo sapiens
108 RHOB 388
Proximity Label-MS Homo sapiens
109 LGALS8 3964
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
110 LPPR2  
Two-hybrid Homo sapiens
111 PRB1  
Two-hybrid Homo sapiens
112 GKN2  
Two-hybrid Homo sapiens
113 PIGR 5284
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
114 C1GALT1 56913
Two-hybrid Homo sapiens
115 GYPA  
Two-hybrid Homo sapiens
116 LRP10 26020
Two-hybrid Homo sapiens
117 ABHD16A 7920
Two-hybrid Homo sapiens
118 SLC38A2 54407
Two-hybrid Homo sapiens
119 CCDC167  
Two-hybrid Homo sapiens
120 CDS1  
Two-hybrid Homo sapiens
121 TMEM254  
Two-hybrid Homo sapiens
122 JCHAIN 3512
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
123 ADAM33 80332
Two-hybrid Homo sapiens
124 IER3IP1 51124
Two-hybrid Homo sapiens
125 LTA  
Two-hybrid Homo sapiens
126 GPR152  
Two-hybrid Homo sapiens
127 FGB 2244
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
128 PNLIPRP1  
Two-hybrid Homo sapiens
129 UNC93B1 81622
Two-hybrid Homo sapiens
130 BTN2A2  
Two-hybrid Homo sapiens
131 SLC38A7 55238
Two-hybrid Homo sapiens
132 FKBP14  
Two-hybrid Homo sapiens
133 APOL3  
Two-hybrid Homo sapiens
134 ADIPOQ 9370
Two-hybrid Homo sapiens
135 RAB2A 5862
Proximity Label-MS Homo sapiens
136 ZG16B 124220
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
137 SEC22A  
Two-hybrid Homo sapiens
138 BNIP2  
Two-hybrid Homo sapiens
139 KRAS 3845
Proximity Label-MS Homo sapiens
140 LTF 4057
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
141 CLDN4 1364
Two-hybrid Homo sapiens
142 SLC52A1  
Two-hybrid Homo sapiens
143 CNIH3  
Two-hybrid Homo sapiens
144 RHD  
Two-hybrid Homo sapiens
145 ATP13A1 57130
Two-hybrid Homo sapiens
146 CXCL16 58191
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which TMEM237 is involved
No pathways found





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