Gene description for GRM2
Gene name glutamate receptor, metabotropic 2
Gene symbol GRM2
Other names/aliases GLUR2
GPRC1B
MGLUR2
mGlu2
Species Homo sapiens
 Database cross references - GRM2
ExoCarta ExoCarta_2912
Entrez Gene 2912
HGNC 4594
MIM 604099
UniProt Q14416  
 GRM2 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for GRM2
Molecular Function
    glutamate receptor activity GO:0008066 TAS
    protein binding GO:0005515 IPI
    calcium channel regulator activity GO:0005246 IBA
    group II metabotropic glutamate receptor activity GO:0001641 IBA
    G-protein coupled receptor activity GO:0004930 TAS
Biological Process
    G-protein coupled glutamate receptor signaling pathway GO:0007216 IBA
    synaptic transmission GO:0007268 TAS
    regulation of synaptic transmission, glutamatergic GO:0051966 IBA
    adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway GO:0007196 IEA
    negative regulation of adenylate cyclase activity GO:0007194 TAS
    glutamate secretion GO:0014047 IEA
Subcellular Localization
    plasma membrane GO:0005886 TAS
    dendrite GO:0030425 IEA
    presynaptic membrane GO:0042734 IBA
    axon GO:0030424 IEA
    intracellular GO:0005622 IEA
    integral component of plasma membrane GO:0005887 TAS
    cell junction GO:0030054 IEA
 Experiment description of studies that identified GRM2 in exosomes
1
Experiment ID 126
ISEV standards
EV Biophysical techniques
GAPDH
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for GRM2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which GRM2 is involved
PathwayEvidenceSource
Class C/3 (Metabotropic glutamate/pheromone receptors) TAS Reactome
G alpha (i) signalling events TAS Reactome





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