Gene description for MGST3
Gene name microsomal glutathione S-transferase 3
Gene symbol MGST3
Other names/aliases GST-III
Species Homo sapiens
 Database cross references - MGST3
ExoCarta ExoCarta_4259
Entrez Gene 4259
HGNC 7064
MIM 604564
UniProt O14880  
 MGST3 identified in exosomes derived from the following tissue/cell type
Squamous carcinoma cells 20124223    
 Gene ontology annotations for MGST3
Molecular Function
    protein binding GO:0005515 IPI
    glutathione transferase activity GO:0004364 IEA
    glutathione peroxidase activity GO:0004602 IBA
    peroxidase activity GO:0004601 TAS
Biological Process
    small molecule metabolic process GO:0044281 TAS
    glutathione derivative biosynthetic process GO:1901687 TAS
    oxidation-reduction process GO:0055114 TAS
    xenobiotic metabolic process GO:0006805 TAS
    signal transduction GO:0007165 TAS
    lipid metabolic process GO:0006629 TAS
Subcellular Localization
    nuclear envelope GO:0005635 IBA
    intracellular membrane-bounded organelle GO:0043231 TAS
    extracellular exosome GO:0070062 IDA
    membrane GO:0016020 IDA
    integral component of membrane GO:0016021 IEA
    endoplasmic reticulum membrane GO:0005789 TAS
 Experiment description of studies that identified MGST3 in exosomes
1
Experiment ID 191
ISEV standards
✘ EV Biophysical techniques
✔
Alix
EV Cytosolic markers
✔
CD81|CD9
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK.
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for MGST3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which MGST3 is involved
PathwayEvidenceSource
Aflatoxin activation and detoxification TAS Reactome
Glutathione conjugation TAS Reactome





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