Gene description for NEU1
Gene name sialidase 1 (lysosomal sialidase)
Gene symbol NEU1
Other names/aliases NANH
NEU
SIAL1
Species Homo sapiens
 Database cross references - NEU1
ExoCarta ExoCarta_4758
Entrez Gene 4758
HGNC 7758
MIM 608272
UniProt Q99519  
 NEU1 identified in exosomes derived from the following tissue/cell type
Saliva 19199708    
 Gene ontology annotations for NEU1
Molecular Function
    exo-alpha-(2->3)-sialidase activity GO:0052794 IEA
    exo-alpha-sialidase activity GO:0004308 IDA
    exo-alpha-(2->8)-sialidase activity GO:0052796 IEA
    exo-alpha-(2->6)-sialidase activity GO:0052795 IEA
Biological Process
    cellular protein metabolic process GO:0044267 TAS
    lipid catabolic process GO:0016042 IEA
    glycosphingolipid metabolic process GO:0006687 TAS
    post-translational protein modification GO:0043687 TAS
    dolichol-linked oligosaccharide biosynthetic process GO:0006488 TAS
    oligosaccharide catabolic process GO:0009313 IMP
    protein N-linked glycosylation via asparagine GO:0018279 TAS
    sphingolipid metabolic process GO:0006665 TAS
    small molecule metabolic process GO:0044281 TAS
Subcellular Localization
    cell junction GO:0030054 IDA
    intracellular membrane-bounded organelle GO:0043231 IDA
    cytoplasmic membrane-bounded vesicle GO:0016023 IEA
    lysosomal lumen GO:0043202 TAS
    plasma membrane GO:0005886 IEA
    lysosomal membrane GO:0005765 IEA
    lysosome GO:0005764 IDA
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified NEU1 in exosomes
1
Experiment ID 66
ISEV standards
IEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
CD63|CD81
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for NEU1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CTSA 5476
Invitro Homo sapiens
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
2 EEF1A1 1915
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which NEU1 is involved
PathwayEvidenceSource
Glycosphingolipid metabolism TAS Reactome
Sialic acid metabolism TAS Reactome





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