Gene description for GPX8
Gene name glutathione peroxidase 8 (putative)
Gene symbol GPX8
Other names/aliases EPLA847
GPx-8
GSHPx-8
UNQ847
Species Homo sapiens
 Database cross references - GPX8
ExoCarta ExoCarta_493869
Vesiclepedia VP_493869
Entrez Gene 493869
HGNC 33100
UniProt Q8TED1  
 GPX8 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for GPX8
Molecular Function
    peroxidase activity GO:0004601 EXP
    peroxidase activity GO:0004601 IBA
    glutathione peroxidase activity GO:0004602 IEA
    protein binding GO:0005515 IPI
Biological Process
    cellular response to oxidative stress GO:0034599 TAS
    cellular oxidant detoxification GO:0098869 IEA
Subcellular Localization
    endoplasmic reticulum lumen GO:0005788 TAS
    membrane GO:0016020 IEA
 Experiment description of studies that identified GPX8 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for GPX8
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SEC22B 9554
Two-hybrid Homo sapiens
2 SLC39A12  
Affinity Capture-MS Homo sapiens
3 HFE  
Affinity Capture-MS Homo sapiens
4 RAMP3  
Affinity Capture-MS Homo sapiens
5 VAMP4 8674
Two-hybrid Homo sapiens
6 TM4SF4  
Two-hybrid Homo sapiens
7 GPR151  
Two-hybrid Homo sapiens
8 SLC35A1 10559
Two-hybrid Homo sapiens
9 TMBIM6 7009
Two-hybrid Homo sapiens
10 VTI1B 10490
Two-hybrid Homo sapiens
11 OCLN 100506658
Two-hybrid Homo sapiens
12 VAPA 9218
Affinity Capture-MS Homo sapiens
13 PAEP  
Two-hybrid Homo sapiens
14 SLC39A4 55630
Affinity Capture-MS Homo sapiens
15 ZDHHC22  
Two-hybrid Homo sapiens
16 FA2H  
Two-hybrid Homo sapiens
17 CD53 963
Two-hybrid Homo sapiens
18 CFC1  
Affinity Capture-MS Homo sapiens
19 SLC35B4  
Two-hybrid Homo sapiens
20 GAPDHS 26330
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 MFAP4 4239
Affinity Capture-MS Homo sapiens
22 CYB561D2 11068
Two-hybrid Homo sapiens
23 AIG1  
Two-hybrid Homo sapiens
24 EYA2  
Affinity Capture-MS Homo sapiens
25 GOSR2 9570
Two-hybrid Homo sapiens
26 LNPEP 4012
Two-hybrid Homo sapiens
27 VSTM1  
Two-hybrid Homo sapiens
28 FFAR1  
Affinity Capture-MS Homo sapiens
29 SLC22A9  
Affinity Capture-MS Homo sapiens
30 PAQR5  
Two-hybrid Homo sapiens
31 APOD 347
Two-hybrid Homo sapiens
32 SERINC2 347735
Two-hybrid Homo sapiens
33 FCER1A  
Affinity Capture-MS Homo sapiens
34 MARCH5  
Two-hybrid Homo sapiens
35 TM2D3  
Affinity Capture-MS Homo sapiens
36 KCNJ10  
Affinity Capture-MS Homo sapiens
37 FAM3C 10447
Two-hybrid Homo sapiens
38 APOC3 345
Two-hybrid Homo sapiens
39 TIMMDC1  
Two-hybrid Homo sapiens
40 HARS2 23438
Affinity Capture-MS Homo sapiens
41 C2orf82  
Two-hybrid Homo sapiens
42 MMD  
Two-hybrid Homo sapiens
43 STX8 9482
Two-hybrid Homo sapiens
44 CFHR5  
Two-hybrid Homo sapiens
45 SELK  
Two-hybrid Homo sapiens
46 ST8SIA5  
Affinity Capture-MS Homo sapiens
47 C14orf180  
Two-hybrid Homo sapiens
48 CD3E 916
Affinity Capture-MS Homo sapiens
49 SERP1 27230
Two-hybrid Homo sapiens
50 SLC34A3  
Two-hybrid Homo sapiens
51 ATP2A3 489
Affinity Capture-MS Homo sapiens
52 LPAR3  
Two-hybrid Homo sapiens
53 NEU1 4758
Two-hybrid Homo sapiens
54 TMEM97 27346
Two-hybrid Homo sapiens
55 CD1A 909
Affinity Capture-MS Homo sapiens
56 LIPG 9388
Affinity Capture-MS Homo sapiens
57 SMAGP  
Two-hybrid Homo sapiens
58 BET1 10282
Two-hybrid Homo sapiens
59 B3GAT3 26229
Affinity Capture-MS Homo sapiens
60 SYT15  
Two-hybrid Homo sapiens
61 SNX27 81609
Affinity Capture-MS Homo sapiens
62 TMEM107 84314
Two-hybrid Homo sapiens
63 BTNL2  
Affinity Capture-MS Homo sapiens
64 TMEM106A  
Affinity Capture-MS Homo sapiens
65 LEPROTL1 23484
Two-hybrid Homo sapiens
66 CLDND1 56650
Affinity Capture-MS Homo sapiens
67 KIF14 9928
Affinity Capture-MS Homo sapiens
68 RND1  
Two-hybrid Homo sapiens
69 TMEM254  
Two-hybrid Homo sapiens
70 INSIG2  
Two-hybrid Homo sapiens
71 EFNA2  
Affinity Capture-MS Homo sapiens
72 RTP2  
Two-hybrid Homo sapiens
73 IL9R  
Affinity Capture-MS Homo sapiens
74 VKORC1L1 154807
Two-hybrid Homo sapiens
75 TMEM14B  
Two-hybrid Homo sapiens
76 ERO1L 30001
PCA Homo sapiens
77 TSPAN33 340348
Two-hybrid Homo sapiens
78 IGFBP5 3488
Two-hybrid Homo sapiens
79 MFSD6 54842
Two-hybrid Homo sapiens
80 AGTRAP 57085
Two-hybrid Homo sapiens
81 ASNA1 439
Two-hybrid Homo sapiens
82 THBD 7056
Two-hybrid Homo sapiens
83 EDDM3B  
Two-hybrid Homo sapiens
84 YIF1A 10897
Two-hybrid Homo sapiens
85 TMEM50B 757
Two-hybrid Homo sapiens
86 MYADML2  
Two-hybrid Homo sapiens
87 BCL2L2 599
Two-hybrid Homo sapiens
88 SLC41A2 84102
Two-hybrid Homo sapiens
89 COL8A2 1296
Two-hybrid Homo sapiens
90 DHH  
Affinity Capture-MS Homo sapiens
91 CD81 975
Two-hybrid Homo sapiens
92 CENPH  
Affinity Capture-MS Homo sapiens
93 SLC30A3  
Two-hybrid Homo sapiens
94 DNAJC30  
Two-hybrid Homo sapiens
95 CLDN19  
Two-hybrid Homo sapiens
96 SDF2L1 23753
Affinity Capture-MS Homo sapiens
97 LHFPL5  
Two-hybrid Homo sapiens
98 PTPRO 5800
Affinity Capture-MS Homo sapiens
99 ZACN  
Affinity Capture-MS Homo sapiens
100 CHRND  
Affinity Capture-MS Homo sapiens
101 TRAM1L1  
Two-hybrid Homo sapiens
102 CDIPT 10423
Two-hybrid Homo sapiens
103 TMEM60  
Two-hybrid Homo sapiens
104 CHST1 8534
Two-hybrid Homo sapiens
105 C16orf72 29035
Affinity Capture-MS Homo sapiens
106 HTR3A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
107 CDS2 8760
Two-hybrid Homo sapiens
108 TMEM128  
Two-hybrid Homo sapiens
109 LAPTM4B  
Two-hybrid Homo sapiens
110 TOR1AIP1 26092
Affinity Capture-MS Homo sapiens
111 AQP2 359
Two-hybrid Homo sapiens
112 UPK1B 7348
Two-hybrid Homo sapiens
113 BMP10  
Two-hybrid Homo sapiens
114 CANX 821
Affinity Capture-MS Homo sapiens
115 TMEM243  
Two-hybrid Homo sapiens
116 C14orf1 11161
Two-hybrid Homo sapiens
117 LRRC59 55379
Proximity Label-MS Homo sapiens
118 CHST6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
119 KLRG1  
Two-hybrid Homo sapiens
120 TNFSF8  
Affinity Capture-MS Homo sapiens
121 HMOX2 3163
Two-hybrid Homo sapiens
122 SREBF1 6720
Negative Genetic Homo sapiens
123 CHRNA1  
Affinity Capture-MS Homo sapiens
124 UNC50  
Two-hybrid Homo sapiens
125 PAQR6  
Two-hybrid Homo sapiens
126 WDR3  
Cross-Linking-MS (XL-MS) Homo sapiens
127 LPAR2 9170
Affinity Capture-MS Homo sapiens
128 TSPAN18 90139
Affinity Capture-MS Homo sapiens
129 KLRD1  
Affinity Capture-MS Homo sapiens
130 NRM 11270
Two-hybrid Homo sapiens
131 FAXDC2  
Two-hybrid Homo sapiens
132 AQP3  
Two-hybrid Homo sapiens
133 KIR2DL3  
Two-hybrid Homo sapiens
134 CORIN  
Two-hybrid Homo sapiens
135 PLLP  
Two-hybrid Homo sapiens
136 SERINC1 57515
Two-hybrid Homo sapiens
137 TMEM42  
Two-hybrid Homo sapiens
138 CLEC4E  
Affinity Capture-MS Homo sapiens
139 TMEM86B  
Two-hybrid Homo sapiens
140 KLRB1  
Affinity Capture-MS Homo sapiens
141 HLA-DQA1 3117
Affinity Capture-MS Homo sapiens
142 ALG8  
Two-hybrid Homo sapiens
143 TMEM229B  
Two-hybrid Homo sapiens
144 PRB1  
Two-hybrid Homo sapiens
145 RPA3 6119
Proximity Label-MS Homo sapiens
146 CLEC1A  
Two-hybrid Homo sapiens
147 COL4A5  
Two-hybrid Homo sapiens
148 CMTM5  
Two-hybrid Homo sapiens
149 A4GNT  
Affinity Capture-MS Homo sapiens
150 DOLK 22845
Two-hybrid Homo sapiens
151 PPAPDC1A  
Two-hybrid Homo sapiens
152 ASPH 444
Two-hybrid Homo sapiens
153 SLC13A3 64849
Two-hybrid Homo sapiens
154 GXYLT1 283464
Affinity Capture-MS Homo sapiens
155 CLEC2A  
Two-hybrid Homo sapiens
156 PLP2 5355
Two-hybrid Homo sapiens
157 CACNG1  
Two-hybrid Homo sapiens
158 PPAPDC2  
Two-hybrid Homo sapiens
159 MIP  
Two-hybrid Homo sapiens
160 NKG7  
Two-hybrid Homo sapiens
161 ITM2C 81618
Affinity Capture-MS Homo sapiens
162 KCNK16  
Affinity Capture-MS Homo sapiens
163 HUWE1 10075
Affinity Capture-MS Homo sapiens
164 ASGR1 432
Two-hybrid Homo sapiens
165 C1GALT1 56913
Two-hybrid Homo sapiens
166 GYPA  
Two-hybrid Homo sapiens
167 TMEM19  
Two-hybrid Homo sapiens
168 AQP1 358
Two-hybrid Homo sapiens
169 CD302 9936
Two-hybrid Homo sapiens
170 TMED10 10972
Affinity Capture-MS Homo sapiens
171 HLA-G 3135
Affinity Capture-MS Homo sapiens
172 RBFA  
Two-hybrid Homo sapiens
173 TMEM218  
Two-hybrid Homo sapiens
174 FBXL6  
Affinity Capture-MS Homo sapiens
175 GP9 2815
Affinity Capture-MS Homo sapiens
176 PGRMC1 10857
Affinity Capture-MS Homo sapiens
177 CYB561A3 220002
Two-hybrid Homo sapiens
178 TMEM120B  
Two-hybrid Homo sapiens
179 NINJ1 4814
Two-hybrid Homo sapiens
180 PRG2  
Affinity Capture-MS Homo sapiens
181 PNLIPRP1  
Two-hybrid Homo sapiens
182 GRINA  
Two-hybrid Homo sapiens
183 BTN2A2  
Two-hybrid Homo sapiens
184 SCARB2 950
Two-hybrid Homo sapiens
185 GGH 8836
Affinity Capture-MS Homo sapiens
186 TMPRSS4 56649
Two-hybrid Homo sapiens
187 APOM 55937
Affinity Capture-MS Homo sapiens
188 SFTPC  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
189 TMUB2  
Two-hybrid Homo sapiens
190 PLN  
Two-hybrid Homo sapiens
191 BRICD5  
Affinity Capture-MS Homo sapiens
192 SGMS2 166929
Two-hybrid Homo sapiens
193 STX3 6809
Two-hybrid Homo sapiens
194 SPPL2B 56928
Affinity Capture-MS Homo sapiens
195 UGT1A7 54577
Affinity Capture-MS Homo sapiens
196 MFSD5  
Two-hybrid Homo sapiens
197 GPR37L1  
Two-hybrid Homo sapiens
198 TMEM109 79073
Two-hybrid Homo sapiens
199 BNIP2  
Two-hybrid Homo sapiens
200 VAMP5 10791
Two-hybrid Homo sapiens
201 PGAP2  
Two-hybrid Homo sapiens
202 KRAS 3845
Negative Genetic Homo sapiens
203 ST6GAL2  
Two-hybrid Homo sapiens
204 HTR1B  
Affinity Capture-MS Homo sapiens
205 SERTM1  
Two-hybrid Homo sapiens
206 CCDC47 57003
Affinity Capture-MS Homo sapiens
207 LOC102724488  
Two-hybrid Homo sapiens
208 SLC1A1 6505
Affinity Capture-MS Homo sapiens
209 PTCH1  
Affinity Capture-MS Homo sapiens
210 OR1D4  
Affinity Capture-MS Homo sapiens
211 CNIH3  
Two-hybrid Homo sapiens
212 MGST3 4259
Two-hybrid Homo sapiens
213 YIPF6 286451
Two-hybrid Homo sapiens
214 HLA-C 3107
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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