Gene description for SERINC2
Gene name serine incorporator 2
Gene symbol SERINC2
Other names/aliases FKSG84
PRO0899
TDE2
TDE2L
Species Homo sapiens
 Database cross references - SERINC2
ExoCarta ExoCarta_347735
Vesiclepedia VP_347735
Entrez Gene 347735
HGNC 23231
MIM 614549
UniProt Q96SA4  
 SERINC2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Urine 19056867    
 Gene ontology annotations for SERINC2
Subcellular Localization
    membrane GO:0016020 IBA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified SERINC2 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for SERINC2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SEC22B 9554
Two-hybrid Homo sapiens
2 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
3 ATP6V0D1 9114
Affinity Capture-MS Homo sapiens
4 TMEM239  
Two-hybrid Homo sapiens
5 SMAGP  
Two-hybrid Homo sapiens
6 LAT 27040
Two-hybrid Homo sapiens
7 GPX8 493869
Two-hybrid Homo sapiens
8 GPRC5C 55890
Affinity Capture-MS Homo sapiens
9 RAB21 23011
Affinity Capture-MS Homo sapiens
10 SLC12A7 10723
Two-hybrid Homo sapiens
11 TMBIM6 7009
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 CCDC167  
Two-hybrid Homo sapiens
13 ATP6AP1 537
Affinity Capture-MS Homo sapiens
14 NAPA 8775
Affinity Capture-MS Homo sapiens
15 GPR89B 51463
Affinity Capture-MS Homo sapiens
16 LGALS3 3958
Affinity Capture-MS Homo sapiens
17 VKORC1L1 154807
Affinity Capture-MS Homo sapiens
18 TMEM54  
Two-hybrid Homo sapiens
19 ATP6V0D2 245972
Affinity Capture-MS Homo sapiens
20 HS2ST1 9653
Affinity Capture-MS Homo sapiens
21 VAMP3 9341
Affinity Capture-MS Homo sapiens
22 ATP6AP2 10159
Affinity Capture-MS Homo sapiens
23 FUT8 2530
Affinity Capture-MS Homo sapiens
24 TMEM42  
Two-hybrid Homo sapiens
25 SLC29A2 3177
Two-hybrid Homo sapiens
26 STOM 2040
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 GHITM 27069
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 RABL3 285282
Affinity Capture-MS Homo sapiens
29 TMEM86B  
Two-hybrid Homo sapiens
30 SOAT1 6646
Affinity Capture-MS Homo sapiens
31 CNIH4  
Affinity Capture-MS Homo sapiens
32 SEC62 7095
Affinity Capture-MS Homo sapiens
33 NIN 51199
Affinity Capture-MS Homo sapiens
34 HARS2 23438
Affinity Capture-MS Homo sapiens
35 C4orf3  
Two-hybrid Homo sapiens
36 SIGMAR1 10280
Affinity Capture-MS Homo sapiens
37 ATP6V0A2 23545
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 ADGRE5 976
Affinity Capture-MS Homo sapiens
39 GOLM1 51280
Affinity Capture-MS Homo sapiens
40 ATP6V0A1 535
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 TKFC 26007
Affinity Capture-MS Homo sapiens
42 PAF1 54623
Affinity Capture-MS Homo sapiens
43 CKAP4 10970
Affinity Capture-MS Homo sapiens
44 RER1 11079
Affinity Capture-MS Homo sapiens
45 FAM49B 51571
Affinity Capture-MS Homo sapiens
46 FLOT2 2319
Affinity Capture-MS Homo sapiens
47 MFF 56947
Two-hybrid Homo sapiens
48 PGRMC2 10424
Affinity Capture-MS Homo sapiens
49 PTRH2 51651
Affinity Capture-MS Homo sapiens
50 MYOF 26509
Affinity Capture-MS Homo sapiens
51 TMEM167B  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which SERINC2 is involved
PathwayEvidenceSource
Metabolism TAS Reactome
Metabolism of amino acids and derivatives TAS Reactome
Serine biosynthesis TAS Reactome





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