Gene description for VKORC1L1
Gene name vitamin K epoxide reductase complex, subunit 1-like 1
Gene symbol VKORC1L1
Other names/aliases -
Species Homo sapiens
 Database cross references - VKORC1L1
ExoCarta ExoCarta_154807
Vesiclepedia VP_154807
Entrez Gene 154807
HGNC 21492
MIM 608838
UniProt Q8N0U8  
 VKORC1L1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for VKORC1L1
Molecular Function
    protein binding GO:0005515 IPI
    vitamin-K-epoxide reductase (warfarin-sensitive) activity GO:0047057 EXP
    vitamin-K-epoxide reductase (warfarin-sensitive) activity GO:0047057 IBA
    vitamin-K-epoxide reductase (warfarin-sensitive) activity GO:0047057 IDA
    quinone binding GO:0048038 IEA
Biological Process
    peptidyl-glutamic acid carboxylation GO:0017187 IMP
    cellular response to oxidative stress GO:0034599 IMP
    vitamin K metabolic process GO:0042373 IBA
    vitamin K metabolic process GO:0042373 IDA
    vitamin K metabolic process GO:0042373 TAS
Subcellular Localization
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum membrane GO:0005789 IDA
    endoplasmic reticulum membrane GO:0005789 TAS
 Experiment description of studies that identified VKORC1L1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for VKORC1L1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
2 SLC39A12  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 FAS 355
Proximity Label-MS Homo sapiens
4 GPM6A 2823
Affinity Capture-MS Homo sapiens
5 MS4A3  
Two-hybrid Homo sapiens
6 GJD3  
Proximity Label-MS Homo sapiens
7 TM4SF20  
Affinity Capture-MS Homo sapiens
8 C5AR1  
Affinity Capture-MS Homo sapiens
9 TSPAN5 10098
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 VIPR2  
Affinity Capture-MS Homo sapiens
11 ADORA2B  
Affinity Capture-MS Homo sapiens
12 ATP13A3 79572
Affinity Capture-MS Homo sapiens
13 EDNRA 1909
Affinity Capture-MS Homo sapiens
14 TACR1  
Affinity Capture-MS Homo sapiens
15 CXCR4 7852
Affinity Capture-MS Homo sapiens
16 RPN2 6185
Proximity Label-MS Homo sapiens
17 TMEM80  
Two-hybrid Homo sapiens
18 RAB7A 7879
Proximity Label-MS Homo sapiens
19 LAMP3  
Proximity Label-MS Homo sapiens
20 LRRC59 55379
Proximity Label-MS Homo sapiens
21 SLC39A4 55630
Affinity Capture-MS Homo sapiens
22 HTR1B  
Affinity Capture-MS Homo sapiens
23 MTIF3  
Two-hybrid Homo sapiens
24 RAMP3  
Affinity Capture-MS Homo sapiens
25 KCNK1  
Affinity Capture-MS Homo sapiens
26 TMEM184A  
Affinity Capture-MS Homo sapiens
27 CMKLR1 1240
Affinity Capture-MS Homo sapiens
28 ACKR2  
Affinity Capture-MS Homo sapiens
29 ERGIC3 51614
Two-hybrid Homo sapiens
30 BCAP31 10134
Proximity Label-MS Homo sapiens
31 HSD3B7 80270
Proximity Label-MS Homo sapiens
32 TSPAN15 23555
Affinity Capture-MS Homo sapiens
33 TSPAN33 340348
Affinity Capture-MS Homo sapiens
34 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
35 SPPL2B 56928
Affinity Capture-MS Homo sapiens
36 AGPAT3 56894
Affinity Capture-MS Homo sapiens
37 ERGIC1 57222
Proximity Label-MS Homo sapiens
38 P2RY8  
Affinity Capture-MS Homo sapiens
39 FFAR1  
Affinity Capture-MS Homo sapiens
40 PIGN 23556
Affinity Capture-MS Homo sapiens
41 PGAP3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 SERINC2 347735
Affinity Capture-MS Homo sapiens
43 TSPAN2 10100
Affinity Capture-MS Homo sapiens
44 GORAB 92344
Two-hybrid Homo sapiens
45 GPX8 493869
Two-hybrid Homo sapiens
46 RPA3 6119
Proximity Label-MS Homo sapiens
47 GPR52  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 C12orf49  
Negative Genetic Homo sapiens
49 GP5 2814
Affinity Capture-MS Homo sapiens
50 MOV10 4343
Affinity Capture-RNA Homo sapiens
51 SLC6A5  
Affinity Capture-MS Homo sapiens
52 SEC62 7095
Proximity Label-MS Homo sapiens
53 ATP2A1 487
Proximity Label-MS Homo sapiens
54 PCYT1B 9468
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
55 FPR2  
Affinity Capture-MS Homo sapiens
56 P2RY1  
Affinity Capture-MS Homo sapiens
57 SLC10A1  
Affinity Capture-MS Homo sapiens
58 GPC3 2719
Affinity Capture-MS Homo sapiens
59 AP1B1 162
Affinity Capture-MS Homo sapiens
60 HM13 81502
Affinity Capture-MS Homo sapiens
61 VKORC1 79001
Affinity Capture-Western Homo sapiens
62 CISD2 493856
Two-hybrid Homo sapiens
63 RPN1 6184
Proximity Label-MS Homo sapiens
64 P2RY2 5029
Affinity Capture-MS Homo sapiens
65 RAB5C 5878
Proximity Label-MS Homo sapiens
66 TMEM63A 9725
Affinity Capture-MS Homo sapiens
67 VIPR1  
Affinity Capture-MS Homo sapiens
68 SSR1 6745
Proximity Label-MS Homo sapiens
69 SLC1A1 6505
Affinity Capture-MS Homo sapiens
70 PCYT1A 5130
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
71 AGTR1  
Affinity Capture-MS Homo sapiens
72 GPR173  
Affinity Capture-MS Homo sapiens
73 ADGRE5 976
Affinity Capture-MS Homo sapiens
74 SEC61B 10952
Proximity Label-MS Homo sapiens
75 MRM1  
Two-hybrid Homo sapiens
76 P2RY12 64805
Affinity Capture-MS Homo sapiens
77 MEA1  
Affinity Capture-MS Homo sapiens
78 GCNT2 2651
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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