Gene description for ATP13A3
Gene name ATPase type 13A3
Gene symbol ATP13A3
Other names/aliases AFURS1
Species Homo sapiens
 Database cross references - ATP13A3
ExoCarta ExoCarta_79572
Vesiclepedia VP_79572
Entrez Gene 79572
HGNC 24113
MIM 610232
UniProt Q9H7F0  
 ATP13A3 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for ATP13A3
Molecular Function
    ATP binding GO:0005524 IEA
    polyamine transmembrane transporter activity GO:0015203 IBA
    ABC-type putrescine transporter activity GO:0015594 IEA
    P-type ion transporter activity GO:0015662 IEA
    ATP hydrolysis activity GO:0016887 IEA
    ATPase-coupled monoatomic cation transmembrane transporter activity GO:0019829 IBA
    metal ion binding GO:0046872 IEA
    P-type transmembrane transporter activity GO:0140358 IDA
Biological Process
    intracellular calcium ion homeostasis GO:0006874 IBA
    putrescine transport GO:0015847 IEA
    monoatomic cation transmembrane transport GO:0098655 IEA
    polyamine transmembrane transport GO:1902047 IBA
Subcellular Localization
    membrane GO:0016020 HDA
    early endosome membrane GO:0031901 IDA
    late endosome membrane GO:0031902 IBA
    late endosome membrane GO:0031902 IDA
    recycling endosome membrane GO:0055038 IDA
 Experiment description of studies that identified ATP13A3 in exosomes
1
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 211
MISEV standards
EM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
cytochrome c|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 212
MISEV standards
CEM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
Cytochrome C|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ATP13A3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DPY19L1 23333
Affinity Capture-MS Homo sapiens
2 STARD3NL 83930
Affinity Capture-MS Homo sapiens
3 TPRA1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 GJD3  
Proximity Label-MS Homo sapiens
5 C5AR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 C5AR1  
Affinity Capture-MS Homo sapiens
7 OR10H2  
Affinity Capture-MS Homo sapiens
8 MARCKS 4082
Proximity Label-MS Homo sapiens
9 LAMP3  
Proximity Label-MS Homo sapiens
10 SLC39A4 55630
Affinity Capture-MS Homo sapiens
11 GJA1 2697
Proximity Label-MS Homo sapiens
12 HCST  
Affinity Capture-MS Homo sapiens
13 ORMDL3 94103
Affinity Capture-MS Homo sapiens
14 TMED5 50999
Affinity Capture-MS Homo sapiens
15 JPH1 56704
Affinity Capture-MS Homo sapiens
16 HCRTR2  
Affinity Capture-MS Homo sapiens
17 TYROBP  
Affinity Capture-MS Homo sapiens
18 TMEM9B 56674
Affinity Capture-MS Homo sapiens
19 LAMP2 3920
Proximity Label-MS Homo sapiens
20 GPR114  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 FFAR1  
Affinity Capture-MS Homo sapiens
22 WDR41  
Affinity Capture-MS Homo sapiens
23 LGALS9B 284194
Affinity Capture-MS Homo sapiens
24 FAM57A  
Affinity Capture-MS Homo sapiens
25 CYP19A1  
Affinity Capture-MS Homo sapiens
26 GPR88  
Affinity Capture-MS Homo sapiens
27 STX7 8417
Proximity Label-MS Homo sapiens
28 KRTCAP2 200185
Affinity Capture-MS Homo sapiens
29 LGALS12  
Affinity Capture-MS Homo sapiens
30 GPR55  
Affinity Capture-MS Homo sapiens
31 YIPF3 25844
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 GPRC5B 51704
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 RER1 11079
Affinity Capture-MS Homo sapiens
34 PIGH  
Affinity Capture-MS Homo sapiens
35 P2RY10  
Affinity Capture-MS Homo sapiens
36 C3orf52  
Affinity Capture-MS Homo sapiens
37 FADS1 3992
Affinity Capture-MS Homo sapiens
38 F2RL1  
Affinity Capture-MS Homo sapiens
39 BET1 10282
Affinity Capture-MS Homo sapiens
40 LGALS9 3965
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 RAB35 11021
Proximity Label-MS Homo sapiens
42 ISLR 3671
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 DHCR24 1718
Affinity Capture-MS Homo sapiens
44 AGPAT4 56895
Affinity Capture-MS Homo sapiens
45 GPR17 2840
Affinity Capture-MS Homo sapiens
46 LAMTOR1 55004
Proximity Label-MS Homo sapiens
47 RAB4A 5867
Proximity Label-MS Homo sapiens
48 PXMP2  
Affinity Capture-MS Homo sapiens
49 VKORC1L1 154807
Affinity Capture-MS Homo sapiens
50 P2RY8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 TSPAN3 10099
Affinity Capture-MS Homo sapiens
52 LYN 4067
Proximity Label-MS Homo sapiens
53 SKAP2 8935
Affinity Capture-MS Homo sapiens
54 GPR35  
Affinity Capture-MS Homo sapiens
55 PIGM  
Affinity Capture-MS Homo sapiens
56 SLC43A3 29015
Affinity Capture-MS Homo sapiens
57 GPR182  
Affinity Capture-MS Homo sapiens
58 B3GAT2  
Affinity Capture-MS Homo sapiens
59 TMEM56  
Affinity Capture-MS Homo sapiens
60 UQCRH 7388
Affinity Capture-MS Homo sapiens
61 GPR173  
Affinity Capture-MS Homo sapiens
62 TMCO3 55002
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 UPK2 7379
Affinity Capture-MS Homo sapiens
64 SPPL3  
Affinity Capture-MS Homo sapiens
65 ATP9A 10079
Affinity Capture-MS Homo sapiens
66 P2RY2 5029
Affinity Capture-MS Homo sapiens
67 VIPR2  
Affinity Capture-MS Homo sapiens
68 AIFM1 9131
Affinity Capture-MS Homo sapiens
69 RAB5A 5868
Proximity Label-MS Homo sapiens
70 ZDHHC12  
Affinity Capture-MS Homo sapiens
71 LAMP1 3916
Proximity Label-MS Homo sapiens
72 MGARP  
Affinity Capture-MS Homo sapiens
73 HSD3B7 80270
Proximity Label-MS Homo sapiens
74 NIPAL1  
Affinity Capture-MS Homo sapiens
75 KLRD1  
Affinity Capture-MS Homo sapiens
76 ARF6 382
Proximity Label-MS Homo sapiens
77 SLC7A3  
Affinity Capture-MS Homo sapiens
78 LHFP 10186
Affinity Capture-MS Homo sapiens
79 SLC35B2 347734
Affinity Capture-MS Homo sapiens
80 CHRNB4  
Affinity Capture-MS Homo sapiens
81 RFT1 91869
Affinity Capture-MS Homo sapiens
82 GPR45  
Affinity Capture-MS Homo sapiens
83 CMTM5  
Affinity Capture-MS Homo sapiens
84 RAB9A 9367
Proximity Label-MS Homo sapiens
85 DOLK 22845
Affinity Capture-MS Homo sapiens
86 YIPF4 84272
Affinity Capture-MS Homo sapiens
87 B3GAT3 26229
Affinity Capture-MS Homo sapiens
88 RHOB 388
Proximity Label-MS Homo sapiens
89 LGALS8 3964
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
90 SLC22A4 6583
Affinity Capture-MS Homo sapiens
91 P2RX2  
Affinity Capture-MS Homo sapiens
92 AVPR2  
Affinity Capture-MS Homo sapiens
93 MAS1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
94 ELOVL3  
Affinity Capture-MS Homo sapiens
95 TMEM161B  
Affinity Capture-MS Homo sapiens
96 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
97 FASN 2194
Negative Genetic Homo sapiens
98 ANKFY1 51479
Proximity Label-MS Homo sapiens
99 GPR89A  
Affinity Capture-MS Homo sapiens
100 TMEM9 252839
Affinity Capture-MS Homo sapiens
101 GP9 2815
Affinity Capture-MS Homo sapiens
102 OPALIN  
Affinity Capture-MS Homo sapiens
103 LGALS3 3958
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
104 TSPAN15 23555
Affinity Capture-MS Homo sapiens
105 B4GAT1 11041
Affinity Capture-MS Homo sapiens
106 AGPAT3 56894
Affinity Capture-MS Homo sapiens
107 C11orf52 91894
Proximity Label-MS Homo sapiens
108 SLC10A7  
Affinity Capture-MS Homo sapiens
109 ND4 4538
Affinity Capture-MS Homo sapiens
110 AUP1 550
Affinity Capture-MS Homo sapiens
111 HACD2 201562
Affinity Capture-MS Homo sapiens
112 RAB2A 5862
Proximity Label-MS Homo sapiens
113 SPCS1 28972
Affinity Capture-MS Homo sapiens
114 SPPL2B 56928
Affinity Capture-MS Homo sapiens
115 RAB11A 8766
Proximity Label-MS Homo sapiens
116 TPST2 8459
Affinity Capture-MS Homo sapiens
117 KRAS 3845
Proximity Label-MS Homo sapiens
118 RAB5C 5878
Proximity Label-MS Homo sapiens
119 CCR6  
Affinity Capture-MS Homo sapiens
120 ZDHHC13 54503
Affinity Capture-MS Homo sapiens
121 BRI3BP 140707
Affinity Capture-MS Homo sapiens
122 FPR2  
Affinity Capture-MS Homo sapiens
123 S1PR4  
Affinity Capture-MS Homo sapiens
124 ENTPD4 9583
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ATP13A3 is involved
No pathways found





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