Gene description for BRI3BP
Gene name BRI3 binding protein
Gene symbol BRI3BP
Other names/aliases BNAS1
HCCR-1
HCCR-2
HCCRBP-1
KG19
Species Homo sapiens
 Database cross references - BRI3BP
ExoCarta ExoCarta_140707
Vesiclepedia VP_140707
Entrez Gene 140707
HGNC 14251
MIM 615627
UniProt Q8WY22  
 BRI3BP identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Colorectal cancer cells 17956143    
Liver cancer cells 25265333    
Liver cancer cells 25265333    
 Gene ontology annotations for BRI3BP
Molecular Function
    protein binding GO:0005515 IPI
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IBA
    mitochondrion GO:0005739 IDA
    mitochondrial outer membrane GO:0005741 IEA
 Experiment description of studies that identified BRI3BP in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 20
MISEV standards
✔
EM
Biophysical techniques
✔
HSP90|CD63|CD81|LAMP1
Enriched markers
✔
GOLGA2|cytochrome c
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17956143    
Organism Homo sapiens
Experiment description Proteomic analysis of microvesicles derived from human colorectal cancer cells.
Authors "Choi DS, Lee JM, Park GW, Lim HW, Bang JY, Kim YK, Kwon KH, Kwon HJ, Kim KP, Gho YS"
Journal name JPR
Publication year 2007
Sample Colorectal cancer cells
Sample name HT29
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Diafiltration
Flotation density 1.16 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
6
Experiment ID 266
MISEV standards
✘ Biophysical techniques
✔
TSG101|Alix
Enriched markers
✔
CANX|HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25265333    
Organism Homo sapiens
Experiment description Quantitative Proteomic Analysis of Exosome Protein Content Changes Induced by Hepatitis B Virus in Huh-7 Cells Using SILAC Labeling and LC-MS/MS
Authors "Zhao X, Wu Y, Duan J, Ma Y, Shen Z, Wei L, Cui X, Zhang J, Xie Y, Liu J"
Journal name J Proteome Res
Publication year 2014
Sample Liver cancer cells
Sample name Huh-7 - Wild type
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
7
Experiment ID 268
MISEV standards
✘ Biophysical techniques
✔
TSG101|Alix
Enriched markers
✔
CANX|HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25265333    
Organism Homo sapiens
Experiment description Quantitative Proteomic Analysis of Exosome Protein Content Changes Induced by Hepatitis B Virus in Huh-7 Cells Using SILAC Labeling and LC-MS/MS
Authors "Zhao X, Wu Y, Duan J, Ma Y, Shen Z, Wei L, Cui X, Zhang J, Xie Y, Liu J"
Journal name J Proteome Res
Publication year 2014
Sample Liver cancer cells
Sample name Huh-7 - Transfected with HBx-null HBV replicon plasmids
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for BRI3BP
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Affinity Capture-MS Homo sapiens
2 HSD17B11 51170
Proximity Label-MS Homo sapiens
3 C5AR1  
Affinity Capture-MS Homo sapiens
4 TOR1A 1861
Affinity Capture-MS Homo sapiens
5 DHCR24 1718
Affinity Capture-MS Homo sapiens
6 METTL7A 25840
Proximity Label-MS Homo sapiens
7 HCST  
Affinity Capture-MS Homo sapiens
8 TUSC5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 ANK1 286
Affinity Capture-MS Homo sapiens
10 TYROBP  
Affinity Capture-MS Homo sapiens
11 DNAJC25 548645
Proximity Label-MS Homo sapiens
12 PRRT2  
Affinity Capture-MS Homo sapiens
13 PIGN 23556
Affinity Capture-MS Homo sapiens
14 RNF5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 SLC6A5  
Affinity Capture-MS Homo sapiens
16 YIPF3 25844
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 GPRC5B 51704
Affinity Capture-MS Homo sapiens
18 SSR1 6745
Proximity Label-MS Homo sapiens
19 CD3E 916
Affinity Capture-MS Homo sapiens
20 CCDC47 57003
Affinity Capture-MS Homo sapiens
21 ATG16L1 55054
Affinity Capture-MS Homo sapiens
22 SIGMAR1 10280
Affinity Capture-MS Homo sapiens
23 BTNL2  
Affinity Capture-MS Homo sapiens
24 FZD7 8324
Affinity Capture-MS Homo sapiens
25 ATP13A3 79572
Affinity Capture-MS Homo sapiens
26 PTH1R  
Affinity Capture-MS Homo sapiens
27 BSG 682
Affinity Capture-MS Homo sapiens
28 LRRC59 55379
Proximity Label-MS Homo sapiens
29 HTR3C  
Affinity Capture-MS Homo sapiens
30 HS2ST1 9653
Affinity Capture-MS Homo sapiens
31 EMD 2010
Proximity Label-MS Homo sapiens
32 AMFR 267
Affinity Capture-MS Homo sapiens
33 SCAP  
Affinity Capture-MS Homo sapiens
34 GPR35  
Affinity Capture-MS Homo sapiens
35 TMEM43 79188
Affinity Capture-MS Homo sapiens
36 Ten1  
Affinity Capture-MS Mus musculus
37 TMED5 50999
Affinity Capture-MS Homo sapiens
38 KCNA6  
Affinity Capture-MS Homo sapiens
39 CCDC107  
Affinity Capture-MS Homo sapiens
40 SMPD3  
Affinity Capture-MS Homo sapiens
41 RPN1 6184
Proximity Label-MS Homo sapiens
42 P2RY2 5029
Affinity Capture-MS Homo sapiens
43 CD63 967
Affinity Capture-MS Homo sapiens
44 TMCO3 55002
Affinity Capture-MS Homo sapiens
45 ZACN  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 TMEM185A  
Affinity Capture-MS Homo sapiens
47 C7orf34  
Affinity Capture-MS Homo sapiens
48 SLC17A2  
Affinity Capture-MS Homo sapiens
49 HLA-DPB1 3115
Affinity Capture-MS Homo sapiens
50 VIPR2  
Affinity Capture-MS Homo sapiens
51 C4orf32  
Affinity Capture-MS Homo sapiens
52 TMED9 54732
Affinity Capture-MS Homo sapiens
53 CXCR4 7852
Affinity Capture-MS Homo sapiens
54 RPN2 6185
Proximity Label-MS Homo sapiens
55 CANX 821
Affinity Capture-MS Homo sapiens
56 CALR3  
Proximity Label-MS Homo sapiens
57 SLC35F2 54733
Affinity Capture-MS Homo sapiens
58 GPR182  
Affinity Capture-MS Homo sapiens
59 BCAP31 10134
Proximity Label-MS Homo sapiens
60 HSD3B7 80270
Proximity Label-MS Homo sapiens
61 LRRC4C  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 LPAR1 1902
Affinity Capture-MS Homo sapiens
63 RPA3 6119
Proximity Label-MS Homo sapiens
64 ATP2A1 487
Proximity Label-MS Homo sapiens
65 CMTM5  
Affinity Capture-MS Homo sapiens
66 DHFRL1  
Proximity Label-MS Homo sapiens
67 RNF2  
Affinity Capture-MS Homo sapiens
68 ADORA1  
Affinity Capture-MS Homo sapiens
69 RNF185  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 GABRD  
Affinity Capture-MS Homo sapiens
71 KCNK16  
Affinity Capture-MS Homo sapiens
72 P2RY12 64805
Affinity Capture-MS Homo sapiens
73 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
74 TSPAN5 10098
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 TMED10 10972
Affinity Capture-MS Homo sapiens
76 DRD3  
Affinity Capture-MS Homo sapiens
77 PDIA4 9601
Proximity Label-MS Homo sapiens
78 CALU 813
Proximity Label-MS Homo sapiens
79 TPTE  
Affinity Capture-MS Homo sapiens
80 TSPAN15 23555
Affinity Capture-MS Homo sapiens
81 DLK1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
82 MKI67  
Affinity Capture-MS Homo sapiens
83 BRK1 55845
Affinity Capture-MS Homo sapiens
84 ESR1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
85 ERGIC2 51290
Proximity Label-MS Homo sapiens
86 GDE1 51573
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
87 SEC61B 10952
Proximity Label-MS Homo sapiens
88 SEC62 7095
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
89 SPPL2B 56928
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
90 DNAJC1 64215
Affinity Capture-MS Homo sapiens
91 VIPR1  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which BRI3BP is involved
No pathways found





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