Gene description for GDE1
Gene name glycerophosphodiester phosphodiesterase 1
Gene symbol GDE1
Other names/aliases 363E6.2
Species Homo sapiens
 Database cross references - GDE1
ExoCarta ExoCarta_51573
Entrez Gene 51573
HGNC 29644
MIM 605943
UniProt Q9NZC3  
 GDE1 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for GDE1
Molecular Function
    metal ion binding GO:0046872 IEA
    glycerophosphoinositol glycerophosphodiesterase activity GO:0047395 IEA
    glycerophosphodiester phosphodiesterase activity GO:0008889 TAS
Biological Process
    glycerol metabolic process GO:0006071 IEA
    lipid metabolic process GO:0006629 TAS
Subcellular Localization
    integral component of membrane GO:0016021 TAS
    cytoplasm GO:0005737 IEA
 Experiment description of studies that identified GDE1 in exosomes
Experiment ID 235
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for GDE1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RGS16 6004
Invitro Homo sapiens
Two-hybrid Homo sapiens
2 RGS19  
Two-hybrid Homo sapiens
3 RGS2  
Invitro Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which GDE1 is involved
No pathways found

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