Gene description for UBAC2
Gene name UBA domain containing 2
Gene symbol UBAC2
Other names/aliases PHGDHL1
Species Homo sapiens
 Database cross references - UBAC2
ExoCarta ExoCarta_337867
Vesiclepedia VP_337867
Entrez Gene 337867
HGNC 20486
UniProt Q8NBM4  
 UBAC2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Chondrocytes 35931686    
Chondrocytes 35931686    
Hepatocellular carcinoma cells 26054723    
Hepatocytes 26054723    
Prostate cancer cells 25844599    
 Gene ontology annotations for UBAC2
Molecular Function
    serine-type endopeptidase activity GO:0004252 IBA
    protein binding GO:0005515 IPI
Biological Process
    Wnt signaling pathway GO:0016055 IEA
    protein localization to endoplasmic reticulum GO:0070972 IDA
    negative regulation of canonical Wnt signaling pathway GO:0090090 IMP
    negative regulation of retrograde protein transport, ER to cytosol GO:1904153 IMP
Subcellular Localization
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum membrane GO:0005789 IEA
 Experiment description of studies that identified UBAC2 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 497
MISEV standards
✘ Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 498
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
7
Experiment ID 235
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
8
Experiment ID 237
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
9
Experiment ID 274
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
✔
AIF
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel resistant
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.18 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Flow cytometry
Western blotting
 Protein-protein interactions for UBAC2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SEC22B 9554
Affinity Capture-MS Homo sapiens
2 Tmed2 56334
Affinity Capture-MS Mus musculus
3 TUBA8 51807
Affinity Capture-MS Homo sapiens
4 NPLOC4 55666
Affinity Capture-MS Homo sapiens
5 ANK2 287
Affinity Capture-MS Homo sapiens
6 REEP5 7905
Proximity Label-MS Homo sapiens
7 HNRNPM 4670
Affinity Capture-MS Homo sapiens
8 VAPA 9218
Affinity Capture-MS Homo sapiens
9 ATG9A 79065
Affinity Capture-MS Homo sapiens
10 SLC39A4 55630
Affinity Capture-MS Homo sapiens
11 ATP6V1C1 528
Co-fractionation Homo sapiens
12 CSNK1A1 1452
Affinity Capture-MS Homo sapiens
13 VDAC1 7416
Affinity Capture-MS Homo sapiens
14 RPL10 6134
Affinity Capture-MS Homo sapiens
15 UBC 7316
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
16 CAND1 55832
Affinity Capture-MS Homo sapiens
17 SLC17A2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 SYVN1 84447
Affinity Capture-Western Homo sapiens
19 GCN1L1 10985
Affinity Capture-MS Homo sapiens
20 SLC22A9  
Affinity Capture-MS Homo sapiens
21 TTC30B  
Affinity Capture-MS Homo sapiens
22 HAL 3034
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 APEX1 328
Affinity Capture-RNA Homo sapiens
24 GP5 2814
Affinity Capture-MS Homo sapiens
25 SPRTN  
Affinity Capture-MS Homo sapiens
26 CYP19A1  
Affinity Capture-MS Homo sapiens
27 SLC6A5  
Affinity Capture-MS Homo sapiens
28 KMT2D 8085
Affinity Capture-MS Homo sapiens
29 CALCOCO2  
Two-hybrid Homo sapiens
30 TMEM201 199953
Affinity Capture-MS Homo sapiens
31 PIGH  
Affinity Capture-MS Homo sapiens
32 C3orf52  
Affinity Capture-MS Homo sapiens
33 TBC1D15 64786
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 EXD2  
Proximity Label-MS Homo sapiens
35 CPA4 51200
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 KPRP 448834
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 ABHD14A  
Affinity Capture-MS Homo sapiens
38 SLC25A46 91137
Proximity Label-MS Homo sapiens
39 TOMM40 10452
Affinity Capture-MS Homo sapiens
40 TUBA1A 7846
Affinity Capture-MS Homo sapiens
41 RAB35 11021
Affinity Capture-MS Homo sapiens
42 FAF2 23197
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
43 VWA8 23078
Proximity Label-MS Homo sapiens
44 PCYOX1 51449
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 EMC1 23065
Affinity Capture-MS Homo sapiens
46 TBC1D17 79735
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 SERPINB4 6318
Affinity Capture-MS Homo sapiens
48 TSR1 55720
Co-fractionation Homo sapiens
49 PRPF8 10594
Proximity Label-MS Homo sapiens
50 FASTKD5  
Proximity Label-MS Homo sapiens
51 EMD 2010
Affinity Capture-MS Homo sapiens
52 AMFR 267
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
53 TMEM150A  
Affinity Capture-MS Homo sapiens
54 NONO 4841
Co-fractionation Homo sapiens
55 TMEM43 79188
Affinity Capture-MS Homo sapiens
56 MME 4311
Affinity Capture-MS Homo sapiens
57 VCP 7415
Affinity Capture-MS Homo sapiens
58 MIR182  
Affinity Capture-RNA Homo sapiens
Protein-RNA Homo sapiens
59 GPR182  
Affinity Capture-MS Homo sapiens
60 CLEC11A 6320
Affinity Capture-MS Homo sapiens
61 RPN1 6184
Proximity Label-MS Homo sapiens
62 TMEM63A 9725
Affinity Capture-MS Homo sapiens
63 CHRNA1  
Affinity Capture-MS Homo sapiens
64 TUBB7P 56604
Affinity Capture-MS Homo sapiens
65 CLRN2  
Affinity Capture-MS Homo sapiens
66 BAG3 9531
Affinity Capture-MS Homo sapiens
67 Rab5c 19345
Affinity Capture-MS Mus musculus
68 UFD1L 7353
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 CNGA4  
Affinity Capture-MS Homo sapiens
70 APLNR  
Affinity Capture-MS Homo sapiens
71 TMED9 54732
Affinity Capture-MS Homo sapiens
72 EMC3 55831
Affinity Capture-MS Homo sapiens
73 RPN2 6185
Affinity Capture-MS Homo sapiens
74 SURF4 6836
Affinity Capture-MS Homo sapiens
75 LRRC59 55379
Affinity Capture-MS Homo sapiens
76 PANX1 24145
Proximity Label-MS Homo sapiens
77 S100A16 140576
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
78 STK17B 9262
Affinity Capture-MS Homo sapiens
79 UBE2L6 9246
Affinity Capture-MS Homo sapiens
80 CMKLR1 1240
Affinity Capture-MS Homo sapiens
81 GOLT1B 51026
Affinity Capture-MS Homo sapiens
82 ATP6AP2 10159
Affinity Capture-MS Homo sapiens
83 PTEN 5728
Affinity Capture-MS Homo sapiens
84 CHRNA7  
Affinity Capture-MS Homo sapiens
85 ARF6 382
Proximity Label-MS Homo sapiens
86 S100A7A 338324
Affinity Capture-MS Homo sapiens
87 SLC22A23  
Affinity Capture-MS Homo sapiens
88 Get4  
Affinity Capture-MS Mus musculus
89 EMC2 9694
Affinity Capture-MS Homo sapiens
90 ACAD9 28976
Proximity Label-MS Homo sapiens
91 DUSP9  
Affinity Capture-MS Homo sapiens
92 SLC12A6 9990
Affinity Capture-MS Homo sapiens
93 ADORA1  
Affinity Capture-MS Homo sapiens
94 RNF185  
Affinity Capture-MS Homo sapiens
95 GABRD  
Affinity Capture-MS Homo sapiens
96 PEX3 8504
Proximity Label-MS Homo sapiens
97 KCNK16  
Affinity Capture-MS Homo sapiens
98 PRKDC 5591
Affinity Capture-MS Homo sapiens
99 OR2A4 79541
Affinity Capture-MS Homo sapiens
100 ZRANB1 54764
Affinity Capture-MS Homo sapiens
101 CLPP 8192
Proximity Label-MS Homo sapiens
102 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
103 TSPAN5 10098
Affinity Capture-MS Homo sapiens
104 TSFM 10102
Proximity Label-MS Homo sapiens
105 KCNA2  
Affinity Capture-MS Homo sapiens
106 TP53 7157
Affinity Capture-MS Homo sapiens
107 SIDT2 51092
Affinity Capture-MS Homo sapiens
108 ERLIN1 10613
Affinity Capture-MS Homo sapiens
109 PEX19 5824
Affinity Capture-MS Homo sapiens
110 LONP1 9361
Proximity Label-MS Homo sapiens
111 Itgb1 16412
Affinity Capture-MS Mus musculus
112 XKR6  
Affinity Capture-MS Homo sapiens
113 CLPTM1 1209
Affinity Capture-MS Homo sapiens
114 PDHA1 5160
Proximity Label-MS Homo sapiens
115 TSPAN17 26262
Affinity Capture-MS Homo sapiens
116 ERLIN2 11160
Affinity Capture-MS Homo sapiens
117 KLK7 5650
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
118 UBB 7314
Affinity Capture-MS Homo sapiens
119 GDE1 51573
Affinity Capture-MS Homo sapiens
120 ACTA1 58
Affinity Capture-MS Homo sapiens
121 HM13 81502
Affinity Capture-MS Homo sapiens
122 GLUL 2752
Affinity Capture-MS Homo sapiens
123 CALML5 51806
Affinity Capture-MS Homo sapiens
124 RAB7A 7879
Affinity Capture-MS Homo sapiens
125 SLC25A51  
Proximity Label-MS Homo sapiens
126 C9orf72  
Affinity Capture-MS Homo sapiens
127 TMEM31  
Affinity Capture-MS Homo sapiens
128 KCNC4  
Affinity Capture-MS Homo sapiens
129 COX4I1 1327
Proximity Label-MS Homo sapiens
130 DERL1 79139
Proximity Label-MS Homo sapiens
131 ATP2A1 487
Proximity Label-MS Homo sapiens
View the network image/svg+xml
 Pathways in which UBAC2 is involved
No pathways found





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