Gene description for KLK7
Gene name kallikrein-related peptidase 7
Gene symbol KLK7
Other names/aliases PRSS6
SCCE
hK7
Species Homo sapiens
 Database cross references - KLK7
ExoCarta ExoCarta_5650
Entrez Gene 5650
HGNC 6368
MIM 604438
UniProt P49862  
 KLK7 identified in exosomes derived from the following tissue/cell type
Keratinocytes 19530224    
Keratinocytes 19530224    
 Gene ontology annotations for KLK7
Molecular Function
    serine-type peptidase activity GO:0008236 TAS
    serine-type endopeptidase activity GO:0004252 IEA
Biological Process
    extracellular matrix disassembly GO:0022617 TAS
    proteolysis GO:0006508 IEA
    epidermis development GO:0008544 TAS
    extracellular matrix organization GO:0030198 TAS
Subcellular Localization
    epidermal lamellar body GO:0097209 IDA
    extracellular region GO:0005576 TAS
 Experiment description of studies that identified KLK7 in exosomes
1
Experiment ID 189
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19530224    
Organism Homo sapiens
Experiment description Profile of exosomes related proteins released by differentiated and undifferentiated human keratinocytes.
Authors Chavez-Muñoz C, Kilani RT, Ghahary A.
Journal name J Cell Physiol
Publication year 2009
Sample Keratinocytes
Sample name Keratinocytes - Differentiated
Isolation/purification methods Differential centrifugation
Filtration
Sucrose cushion
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 190
ISEV standards
✔
EM
EV Biophysical techniques
✔
HSC70
EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19530224    
Organism Homo sapiens
Experiment description Profile of exosomes related proteins released by differentiated and undifferentiated human keratinocytes.
Authors Chavez-Muñoz C, Kilani RT, Ghahary A.
Journal name J Cell Physiol
Publication year 2009
Sample Keratinocytes
Sample name Keratinocytes - Undifferentiated
Isolation/purification methods Differential centrifugation
Filtration
Sucrose cushion
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for KLK7
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CDSN 1041
Biochemical Activity Homo sapiens
View the network image/svg+xml
 Pathways in which KLK7 is involved
PathwayEvidenceSource
Degradation of the extracellular matrix TAS Reactome





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